A Non-Stationary Relationship between Global Climate Phenomena and Human Plague Incidence in Madagascar

Katharina S. Kreppel*, Cyril Caminade, Sandra Telfer, Minoarison Rajerison, Lila Rahalison, Andy Morse, Matthew Baylis

*Corresponding author for this work

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Plague, a zoonosis caused by Yersinia pestis, is found in Asia and the Americas, but predominantly in Africa, with the island of Madagascar reporting almost one third of human cases worldwide. Plague's occurrence is affected by local climate factors which in turn are influenced by large-scale climate phenomena such as the El Niño Southern Oscillation (ENSO). The effects of ENSO on regional climate are often enhanced or reduced by a second large-scale climate phenomenon, the Indian Ocean Dipole (IOD). It is known that ENSO and the IOD interact as drivers of disease. Yet the impacts of these phenomena in driving plague dynamics via their effect on regional climate, and specifically contributing to the foci of transmission on Madagascar, are unknown. Here we present the first analysis of the effects of ENSO and IOD on plague in Madagascar.

We use a forty-eight year monthly time-series of reported human plague cases from 1960 to 2008. Using wavelet analysis, we show that over the last fifty years there have been complex non-stationary associations between ENSO/IOD and the dynamics of plague in Madagascar. We demonstrate that ENSO and IOD influence temperature in Madagascar and that temperature and plague cycles are associated. The effects on plague appear to be mediated more by temperature, but precipitation also undoubtedly influences plague in Madagascar. Our results confirm a relationship between plague anomalies and an increase in the intensity of ENSO events and precipitation.

This work widens the understanding of how climate factors acting over different temporal scales can combine to drive local disease dynamics. Given the association of increasing ENSO strength and plague anomalies in Madagascar it may in future be possible to forecast plague outbreaks in Madagascar. The study gives insight into the complex and changing relationship between climate factors and plague in Madagascar.

Original languageEnglish
Article numbere3155
Pages (from-to)1-13
Number of pages13
JournalPLoS Neglected Tropical Diseases
Volume8
Issue number10
DOIs
Publication statusPublished - 9 Oct 2014

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Madagascar
Plague
Climate
Incidence
Indian Ocean
Temperature
Yersinia pestis
Wavelet Analysis
Zoonoses
Islands
Disease Outbreaks

ASJC Scopus subject areas

  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Medicine(all)

Cite this

A Non-Stationary Relationship between Global Climate Phenomena and Human Plague Incidence in Madagascar. / Kreppel, Katharina S.; Caminade, Cyril; Telfer, Sandra; Rajerison, Minoarison; Rahalison, Lila; Morse, Andy; Baylis, Matthew.

In: PLoS Neglected Tropical Diseases, Vol. 8, No. 10, e3155, 09.10.2014, p. 1-13.

Research output: Contribution to journalArticle

Kreppel, Katharina S. ; Caminade, Cyril ; Telfer, Sandra ; Rajerison, Minoarison ; Rahalison, Lila ; Morse, Andy ; Baylis, Matthew. / A Non-Stationary Relationship between Global Climate Phenomena and Human Plague Incidence in Madagascar. In: PLoS Neglected Tropical Diseases. 2014 ; Vol. 8, No. 10. pp. 1-13.
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N1 - Acknowledgments We thank the Plague and Immunology Unit at the Institut Pasteur de Madagascar for data collection and management and supporting the study. Funding The analysis of the study was supported by the Leverhulme Trust Research Leadership Award F/0025/AC: ‘‘Predicting the effects of climate change on infectious diseases of animals’’ (awarded to MB). Funding for KSK was provided by a University of Liverpool PhD studentship award and for MB by BBSRC award ISIS 1813, ‘‘Climate change and the future of plague in Madagascar.’’ The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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