A novel hypothalamic protein regulated by high fat diet and leptin

D. Sergi; A. C. Morris; J. E. Drew; F. M. Campbell; P. Nicol; L. M. Williams

doi:10.1017/S0029665115002165

A novel hypothalamic protein regulated by high fat diet and leptin

D. Sergi, A. C. Morris, J. E. Drew, F. M. Campbell, P. Nicol, L. M. Williams

University of Aberdeen

Research output: Contribution to journal › Abstract › peer-review

Abstract

Obesity is a global health issue. Treatment or prevention of obesity via lifestyle change remains elusive, particularly due to the lack of patient compliance and the subsequent weight regain following the cessation of dietary intervention. The hypothalamus is pivotal in regulating energy homeostasis by matching up energy intake and expenditure. Therefore, identifying novel mechanisms underlying these processes will provide new insights into the treatment of obesity. High-fat feeding has been reported to induce functional and structural impairment of the hypothalamus leading to leptin as well as ghrelin resistance. As a consequence regulation of energy homeostasis is disrupted.

Original language	English
Pages (from-to)	E190
Number of pages	1
Journal	Proceedings of the Nutrition Society
Volume	74
Issue number	OCE3
Early online date	3 Jun 2015
DOIs	https://doi.org/10.1017/S0029665115002165
Publication status	Published - 2015

Keywords

obesity
resistance

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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abstract = "Obesity is a global health issue. Treatment or prevention of obesity via lifestyle change remains elusive, particularly due to the lack of patient compliance and the subsequent weight regain following the cessation of dietary intervention. The hypothalamus is pivotal in regulating energy homeostasis by matching up energy intake and expenditure. Therefore, identifying novel mechanisms underlying these processes will provide new insights into the treatment of obesity. High-fat feeding has been reported to induce functional and structural impairment of the hypothalamus leading to leptin as well as ghrelin resistance. As a consequence regulation of energy homeostasis is disrupted.",

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AU - Morris, A. C.

AU - Drew, J. E.

AU - Campbell, F. M.

AU - Nicol, P.

AU - Williams, L. M.

PY - 2015

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N2 - Obesity is a global health issue. Treatment or prevention of obesity via lifestyle change remains elusive, particularly due to the lack of patient compliance and the subsequent weight regain following the cessation of dietary intervention. The hypothalamus is pivotal in regulating energy homeostasis by matching up energy intake and expenditure. Therefore, identifying novel mechanisms underlying these processes will provide new insights into the treatment of obesity. High-fat feeding has been reported to induce functional and structural impairment of the hypothalamus leading to leptin as well as ghrelin resistance. As a consequence regulation of energy homeostasis is disrupted.

AB - Obesity is a global health issue. Treatment or prevention of obesity via lifestyle change remains elusive, particularly due to the lack of patient compliance and the subsequent weight regain following the cessation of dietary intervention. The hypothalamus is pivotal in regulating energy homeostasis by matching up energy intake and expenditure. Therefore, identifying novel mechanisms underlying these processes will provide new insights into the treatment of obesity. High-fat feeding has been reported to induce functional and structural impairment of the hypothalamus leading to leptin as well as ghrelin resistance. As a consequence regulation of energy homeostasis is disrupted.

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KW - resistance

U2 - 10.1017/S0029665115002165

DO - 10.1017/S0029665115002165

M3 - Abstract

SN - 0029-6651

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JO - Proceedings of the Nutrition Society

JF - Proceedings of the Nutrition Society

IS - OCE3

ER -

A novel hypothalamic protein regulated by high fat diet and leptin

Abstract

Keywords

UN SDGs

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