A novel hypothalamic protein regulated by high fat diet and leptin

D. Sergi, A. C. Morris, J. E. Drew, F. M. Campbell, P. Nicol, L. M. Williams

Research output: Contribution to journalAbstractpeer-review


Obesity is a global health issue. Treatment or prevention of obesity via lifestyle change remains elusive, particularly due to the lack of patient compliance and the subsequent weight regain following the cessation of dietary intervention. The hypothalamus is pivotal in regulating energy homeostasis by matching up energy intake and expenditure. Therefore, identifying novel mechanisms underlying these processes will provide new insights into the treatment of obesity. High-fat feeding has been reported to induce functional and structural impairment of the hypothalamus leading to leptin as well as ghrelin resistance. As a consequence regulation of energy homeostasis is disrupted.
Original languageEnglish
Pages (from-to)E190
Number of pages1
JournalProceedings of the Nutrition Society
Issue numberOCE3
Early online date3 Jun 2015
Publication statusPublished - 2015


  • obesity
  • resistance


Dive into the research topics of 'A novel hypothalamic protein regulated by high fat diet and leptin'. Together they form a unique fingerprint.

Cite this