A standard calculation methodology for human doubly labeled water studies

John R Speakman; Yosuke Yamada; Hiroyuki Sagayama; Elena S F Berman; Philip N Ainslie; Lene F Andersen; Liam J Anderson; Lenore Arab; Issaad Baddou; Kweku Bedu-Addo; Ellen E Blaak; Stephane Blanc; Alberto G Bonomi; Carlijn V C Bouten; Pascal Bovet; Maciej S Buchowski; Nancy F Butte; Stefan G J A Camps; Graeme L Close; Jamie A Cooper; Seth A Creasy; Sai Krupa Das; Richard Cooper; Lara R Dugas; Cara B Ebbeling; Ulf Ekelund; Sonja Entringer; Terrence Forrester; Barry W Fudge; Annelies H Goris; Michael Gurven; Catherine Hambly; Asmaa El Hamdouchi; Marije B Hoos; Sumei Hu; Noorjehan Joonas; Annemiek M Joosen; Peter Katzmarzyk; Kitty P Kempen; Misaka Kimura; William E Kraus; Robert F Kushner; Estelle V Lambert; William R Leonard; Nader Lessan; David S Ludwig; Corby K Martin; Anine C Medin; Erwin P Meijer; James Cameron Morehen; James Peter Morton; Marian L.  Neuhouser; Theresa A.  Nicklas; Robert M.  Ojiambo; Kirsi H.  Pietiläinen; Yannis P Pitsiladis; Jacob  Plange-Rhule; Guy Plasqui; Ross L.  Prentice; Roberto A.  Rabinovich; Susan B.  Racette; David A.  Raichlen; Eric Ravussin; Rebecca M Reynolds; Susan B. Roberts; Albertine J. Schuit; Anders M.  Sjödin; Eric  Stice; Samuel S.  Urlacher; Giulio  Valenti; Ludo M.  Van Etten; Edgar A.  Van Mil; Jonathan C.K.  Wells; George Wilson; Brian M.  Wood; Jack  Yanovski; Tsukasa  Yoshida; Xueying Zhang; Alexia J Murphy-Alford; Cornelia U.  Loechl; Edward L Melanson; Amy H.  Luke; Herman  Pontzer; Jennifer Rood; Dale A Schoeller; Klaas R. Westerterp; William W Wong; IAEA DLW database group

doi:10.1016/j.xcrm.2021.100203

A standard calculation methodology for human doubly labeled water studies

John R Speakman^* (Corresponding Author), Yosuke Yamada^* (Corresponding Author), Hiroyuki Sagayama^* (Corresponding Author), Elena S F Berman, Philip N Ainslie, Lene F Andersen, Liam J Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E Blaak, Stephane Blanc, Alberto G Bonomi, Carlijn V C Bouten, Pascal Bovet, Maciej S Buchowski, Nancy F Butte, Stefan G J A Camps, Graeme L Close, Jamie A CooperSeth A Creasy, Sai Krupa Das, Richard Cooper, Lara R Dugas, Cara B Ebbeling, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W Fudge, Annelies H Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M Joosen, Peter Katzmarzyk, Kitty P Kempen, Misaka Kimura, William E Kraus, Robert F Kushner, Estelle V Lambert, William R Leonard, Nader Lessan, David S Ludwig, Corby K Martin, Anine C Medin, Erwin P Meijer, James Cameron Morehen, James Peter Morton, Marian L. Neuhouser, Theresa A. Nicklas, Robert M. Ojiambo, Kirsi H. Pietiläinen, Yannis P Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L. Prentice, Roberto A. Rabinovich, Susan B. Racette, David A. Raichlen, Eric Ravussin, Rebecca M Reynolds, Susan B. Roberts, Albertine J. Schuit, Anders M. Sjödin, Eric Stice, Samuel S. Urlacher, Giulio Valenti, Ludo M. Van Etten, Edgar A. Van Mil, Jonathan C.K. Wells, George Wilson, Brian M. Wood, Jack Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J Murphy-Alford, Cornelia U. Loechl, Edward L Melanson, Amy H. Luke^* (Corresponding Author), Herman Pontzer^* (Corresponding Author), Jennifer Rood^* (Corresponding Author), Dale A Schoeller^* (Corresponding Author), Klaas R. Westerterp^* (Corresponding Author), William W Wong^* (Corresponding Author), IAEA DLW database group

^*Corresponding author for this work

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Abstract

The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO2 over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.

Original language	English
Article number	100203
Number of pages	12
Journal	Cell reports. Medicine
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/j.xcrm.2021.100203
Publication status	Published - 16 Feb 2021

Bibliographical note

The DLW database, which can be found at https://www.dlwdatabase.org/, is generously supported by the IAEA (Vienna, Austria), Taiyo Nippon Sanso, and SERCON. We are grateful to these companies for their support and especially to Takashi Oono for his tremendous efforts at fund raising on our behalf. The authors also gratefully acknowledge funding from the US National Science Foundation (BCS-1824466) awarded to Herman Pontzer. The funders played no role in the content of this manuscript.

Keywords

doubly labeled water
free-living
total energy expenditure
validation

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Speakman, J. R., Yamada, Y., Sagayama, H., Berman, E. S. F., Ainslie, P. N., Andersen, L. F., Anderson, L. J., Arab, L., Baddou, I., Bedu-Addo, K., Blaak, E. E., Blanc, S., Bonomi, A. G., Bouten, C. V. C., Bovet, P., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Close, G. L., ... IAEA DLW database group (2021). A standard calculation methodology for human doubly labeled water studies. Cell reports. Medicine, 2(2), Article 100203. https://doi.org/10.1016/j.xcrm.2021.100203

Speakman, JR, Yamada, Y, Sagayama, H, Berman, ESF, Ainslie, PN, Andersen, LF, Anderson, LJ, Arab, L, Baddou, I, Bedu-Addo, K, Blaak, EE, Blanc, S, Bonomi, AG, Bouten, CVC, Bovet, P, Buchowski, MS, Butte, NF, Camps, SGJA, Close, GL, Cooper, JA, Creasy, SA, Das, SK, Cooper, R, Dugas, LR, Ebbeling, CB, Ekelund, U, Entringer, S, Forrester, T, Fudge, BW, Goris, AH, Gurven, M, Hambly, C, El Hamdouchi, A, Hoos, MB, Hu, S, Joonas, N, Joosen, AM, Katzmarzyk, P, Kempen, KP, Kimura, M, Kraus, WE, Kushner, RF, Lambert, EV, Leonard, WR, Lessan, N, Ludwig, DS, Martin, CK, Medin, AC, Meijer, EP, Morehen, JC, Morton, JP, Neuhouser, ML, Nicklas, TA, Ojiambo, RM, Pietiläinen, KH, Pitsiladis, YP, Plange-Rhule, J, Plasqui, G, Prentice, RL, Rabinovich, RA, Racette, SB, Raichlen, DA, Ravussin, E, Reynolds, RM, Roberts, SB, Schuit, AJ, Sjödin, AM, Stice, E, Urlacher, SS, Valenti, G, Van Etten, LM, Van Mil, EA, Wells, JCK, Wilson, G, Wood, BM, Yanovski, J, Yoshida, T, Zhang, X, Murphy-Alford, AJ, Loechl, CU, Melanson, EL, Luke, AH, Pontzer, H, Rood, J, Schoeller, DA, Westerterp, KR, Wong, WW & IAEA DLW database group 2021, 'A standard calculation methodology for human doubly labeled water studies', Cell reports. Medicine, vol. 2, no. 2, 100203. https://doi.org/10.1016/j.xcrm.2021.100203

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title = "A standard calculation methodology for human doubly labeled water studies",

abstract = "The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO2 over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.",

keywords = "doubly labeled water, free-living, total energy expenditure, validation",

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note = "The DLW database, which can be found at https://www.dlwdatabase.org/, is generously supported by the IAEA (Vienna, Austria), Taiyo Nippon Sanso, and SERCON. We are grateful to these companies for their support and especially to Takashi Oono for his tremendous efforts at fund raising on our behalf. The authors also gratefully acknowledge funding from the US National Science Foundation (BCS-1824466) awarded to Herman Pontzer. The funders played no role in the content of this manuscript.",

year = "2021",

month = feb,

day = "16",

doi = "10.1016/j.xcrm.2021.100203",

language = "English",

volume = "2",

journal = "Cell reports. Medicine",

issn = "2666-3791",

publisher = "Cell Press",

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TY - JOUR

T1 - A standard calculation methodology for human doubly labeled water studies

AU - Speakman, John R

AU - Yamada, Yosuke

AU - Sagayama, Hiroyuki

AU - Berman, Elena S F

AU - Ainslie, Philip N

AU - Andersen, Lene F

AU - Anderson, Liam J

AU - Arab, Lenore

AU - Baddou, Issaad

AU - Bedu-Addo, Kweku

AU - Blaak, Ellen E

AU - Blanc, Stephane

AU - Bonomi, Alberto G

AU - Bouten, Carlijn V C

AU - Bovet, Pascal

AU - Buchowski, Maciej S

AU - Butte, Nancy F

AU - Camps, Stefan G J A

AU - Close, Graeme L

AU - Cooper, Jamie A

AU - Creasy, Seth A

AU - Das, Sai Krupa

AU - Cooper, Richard

AU - Dugas, Lara R

AU - Ebbeling, Cara B

AU - Ekelund, Ulf

AU - Entringer, Sonja

AU - Forrester, Terrence

AU - Fudge, Barry W

AU - Goris, Annelies H

AU - Gurven, Michael

AU - Hambly, Catherine

AU - El Hamdouchi, Asmaa

AU - Hoos, Marije B

AU - Hu, Sumei

AU - Joonas, Noorjehan

AU - Joosen, Annemiek M

AU - Katzmarzyk, Peter

AU - Kempen, Kitty P

AU - Kimura, Misaka

AU - Kraus, William E

AU - Kushner, Robert F

AU - Lambert, Estelle V

AU - Leonard, William R

AU - Lessan, Nader

AU - Ludwig, David S

AU - Martin, Corby K

AU - Medin, Anine C

AU - Meijer, Erwin P

AU - Morehen, James Cameron

AU - Morton, James Peter

AU - Neuhouser, Marian L.

AU - Nicklas, Theresa A.

AU - Ojiambo, Robert M.

AU - Pietiläinen, Kirsi H.

AU - Pitsiladis, Yannis P

AU - Plange-Rhule, Jacob

AU - Plasqui, Guy

AU - Prentice, Ross L.

AU - Rabinovich, Roberto A.

AU - Racette, Susan B.

AU - Raichlen, David A.

AU - Ravussin, Eric

AU - Reynolds, Rebecca M

AU - Roberts, Susan B.

AU - Schuit, Albertine J.

AU - Sjödin, Anders M.

AU - Stice, Eric

AU - Urlacher, Samuel S.

AU - Valenti, Giulio

AU - Van Etten, Ludo M.

AU - Van Mil, Edgar A.

AU - Wells, Jonathan C.K.

AU - Wilson, George

AU - Wood, Brian M.

AU - Yanovski, Jack

AU - Yoshida, Tsukasa

AU - Zhang, Xueying

AU - Murphy-Alford, Alexia J

AU - Loechl, Cornelia U.

AU - Melanson, Edward L

AU - Luke, Amy H.

AU - Pontzer, Herman

AU - Rood, Jennifer

AU - Schoeller, Dale A

AU - Westerterp, Klaas R.

AU - Wong, William W

AU - IAEA DLW database group

N1 - The DLW database, which can be found at https://www.dlwdatabase.org/, is generously supported by the IAEA (Vienna, Austria), Taiyo Nippon Sanso, and SERCON. We are grateful to these companies for their support and especially to Takashi Oono for his tremendous efforts at fund raising on our behalf. The authors also gratefully acknowledge funding from the US National Science Foundation (BCS-1824466) awarded to Herman Pontzer. The funders played no role in the content of this manuscript.

PY - 2021/2/16

Y1 - 2021/2/16

N2 - The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO2 over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.

AB - The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO2 over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.

KW - doubly labeled water

KW - free-living

KW - total energy expenditure

KW - validation

UR - http://www.scopus.com/inward/record.url?scp=85100971338&partnerID=8YFLogxK

U2 - 10.1016/j.xcrm.2021.100203

DO - 10.1016/j.xcrm.2021.100203

M3 - Article

C2 - 33665639

SN - 2666-3791

VL - 2

JO - Cell reports. Medicine

JF - Cell reports. Medicine

IS - 2

M1 - 100203

ER -

A standard calculation methodology for human doubly labeled water studies

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Keywords

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