Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis

D S Ugdyzhekova, A V Krylatov, N A Bernatskaya, L N Maslov, R Mechoulam, R G Pertwee

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Abstract

We studied the possibility of decreasing the area of ischemic necrosis during myocardial infarction with HU-210, a selective cannabinoid receptor agonist. Activation of cannabinoid receptors with HU-210 had practically no effect on collateral blood flow in the myocardium, but considerably decreased the area of necrosis. There results indicate that cannabinoid receptor agonist HU-210 possesses cardioprotective activity and delays the formation of necrotic zones during coronary occlusion and reperfusion.

Original languageEnglish
Pages (from-to)125-126
Number of pages2
JournalBulletin of Experimental Biology and Medicine
Volume133
Publication statusPublished - 2002

Keywords

  • cannabinoid receptors
  • myocardial infarction

Cite this

Ugdyzhekova, D. S., Krylatov, A. V., Bernatskaya, N. A., Maslov, L. N., Mechoulam, R., & Pertwee, R. G. (2002). Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis. Bulletin of Experimental Biology and Medicine, 133, 125-126.