Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis

D S Ugdyzhekova, A V Krylatov, N A Bernatskaya, L N Maslov, R Mechoulam, R G Pertwee

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We studied the possibility of decreasing the area of ischemic necrosis during myocardial infarction with HU-210, a selective cannabinoid receptor agonist. Activation of cannabinoid receptors with HU-210 had practically no effect on collateral blood flow in the myocardium, but considerably decreased the area of necrosis. There results indicate that cannabinoid receptor agonist HU-210 possesses cardioprotective activity and delays the formation of necrotic zones during coronary occlusion and reperfusion.

Original languageEnglish
Pages (from-to)125-126
Number of pages2
JournalBulletin of Experimental Biology and Medicine
Volume133
Publication statusPublished - 2002

Keywords

  • cannabinoid receptors
  • myocardial infarction

Cite this

Ugdyzhekova, D. S., Krylatov, A. V., Bernatskaya, N. A., Maslov, L. N., Mechoulam, R., & Pertwee, R. G. (2002). Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis. Bulletin of Experimental Biology and Medicine, 133, 125-126.

Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis. / Ugdyzhekova, D S ; Krylatov, A V ; Bernatskaya, N A ; Maslov, L N ; Mechoulam, R ; Pertwee, R G .

In: Bulletin of Experimental Biology and Medicine, Vol. 133, 2002, p. 125-126.

Research output: Contribution to journalArticle

Ugdyzhekova, DS, Krylatov, AV, Bernatskaya, NA, Maslov, LN, Mechoulam, R & Pertwee, RG 2002, 'Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis', Bulletin of Experimental Biology and Medicine, vol. 133, pp. 125-126.
Ugdyzhekova, D S ; Krylatov, A V ; Bernatskaya, N A ; Maslov, L N ; Mechoulam, R ; Pertwee, R G . / Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis. In: Bulletin of Experimental Biology and Medicine. 2002 ; Vol. 133. pp. 125-126.
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AU - Mechoulam, R

AU - Pertwee, R G

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