The effects of episodic infusion of testosterone into the vascular system on energy expenditure, nitrogen retention and whole body protein synthesis (determined from [1-14C]leucine kinetics) were studied in castrated male lambs under conditions of controlled food intake. Comparisons were made between a 10-day control period and a 10-day treatment period for each lamb. Infusion of testosterone produced a significant increase in heat production, but the magnitude (198 kJ/day, +2.5%) was less than the differences in energy expenditure expected between entire and castrated male ruminants. The retention of nitrogen improved by 1.24 g/day (+22%) in response to the administration of androgen, and this was accompanied by a decrease in amino acid oxidation. Total protein synthesis also declined, and the anabolic nature of testosterone supply must, therefore, be effected through a reduction in the breakdown of protein, the mechanism being similar to that proposed for certain anabolic steroids and the beta-agonist, clenbuterol. Contrary to other reports, the presence of testosterone had no effect on the plasma concentration of GH.
|Number of pages||7|
|Journal||Journal of Endocrinology|
|Publication status||Published - 1 Dec 1987|
- Energy Metabolism
- Growth Hormone
- Protein Biosynthesis
Lobley, G., Connell, A., Buchan, V., Skene, P. A., & Fletcher, J. M. (1987). Administration of testosterone to wether lambs: effects on protein and energy metabolism and growth hormone status. Journal of Endocrinology, 115(3), 439-445.