We therefore examined associations between walking age and hip shape at age 60‐64y in 1423 individuals (740 women) from the MRC National Survey of Health and Development, a nationally‐representative British birth cohort. Walking age in months was obtained from maternal interview at age 2y. Ten modes of variation in hip shape (HM1‐HM10), described by statistical shape models, were ascertained from dual‐energy X‐ray absorptiometry (DXA) images.
In sex‐adjusted analyses, earlier walking age was associated with higher HM1 and HM7 scores; these associations were maintained after further adjustment for height, body composition and socioeconomic position. Earlier walking was also associated with lower HM2 scores in women only, and lower HM4 scores in men only. Taken together, this suggests that earlier walkers have proportionately larger (HM4) and flatter (HM1,4) femoral heads, wider (HM1,4,7) and flatter (HM1, 7) femoral necks, smaller neck‐shaft angle (HM1,4), anteversion (HM2,7) and development of osteophytes (HM1).
These results suggest that age at onset of walking in infancy is associated with variations in hip shape in older age. Early walkers have a larger femoral head and neck and smaller neck‐shaft angle; these features are associated with reduced hip fracture risk, but also represent an osteoarthritic‐like phenotype. Unlike results of previous studies of walking age and bone mass, associations in this study were not affected by adjustment for lean mass suggesting that associations may relate directly to skeletal loading in early life when joint shape changes rapidly. This article is protected by copyright. All rights reserved
- bone-muscle interactions
- BONE–MUSCLE INTERACTIONS
- NECK-SHAFT ANGLE
- MRC NATIONAL-SURVEY
- BONE-MUSCLE INTERACTIONS
- BONE STRENGTH
- CAM-TYPE DEFORMITY
- BODY-MASS INDEX
- X-RAY ABSORPTIOMETRY
- PROXIMAL FEMUR
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- School of Medicine, Medical Sciences & Nutrition, Medical Education - Lecturer (Scholarship)
- Aberdeen Centre for Arthritis and Musculoskeletal Health (ACAMH)
Person: Academic Related - Scholarship