Aldosterone inhibition in patients with heart failure with preserved ejection fraction

Christopher J A Neil, Satnam Singh, Michael Frenneaux*

*Corresponding author for this work

Research output: Contribution to journalComment/debate


The Aldosterone Receptor Blockade in Diastolic Heart Failure (Aldo-DHF) study1 tested the hypothesis that aldosterone inhibition with spironolactone would result in improvement in maximum exercise capacity (peak V̇o2) or diastolic function (E/e′), each a co-primary end point. Whereas resting E/e′ was reduced by spironolactone, exercise capacity was not. The method of patient selection may have contributed to a false-negative result. We believe that this study illustrates the fundamental problems with the current concept of heart failure (HF) with preserved ejection fraction (EF) and, in particular, the role of exercise in this syndrome.
Original languageEnglish
Pages (from-to)204
Number of pages1
Issue number2
Publication statusPublished - 10 Jul 2013


ASJC Scopus subject areas

  • Medicine(all)

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