Aldosterone inhibition in patients with heart failure with preserved ejection fraction

Christopher J A Neil, Satnam Singh, Michael Frenneaux

Research output: Contribution to journalComment/debate

Abstract

The Aldosterone Receptor Blockade in Diastolic Heart Failure (Aldo-DHF) study1 tested the hypothesis that aldosterone inhibition with spironolactone would result in improvement in maximum exercise capacity (peak V̇o2) or diastolic function (E/e′), each a co-primary end point. Whereas resting E/e′ was reduced by spironolactone, exercise capacity was not. The method of patient selection may have contributed to a false-negative result. We believe that this study illustrates the fundamental problems with the current concept of heart failure (HF) with preserved ejection fraction (EF) and, in particular, the role of exercise in this syndrome.
Original languageEnglish
Pages (from-to)204
Number of pages1
JournalJAMA
Volume310
Issue number2
DOIs
Publication statusPublished - 10 Jul 2013

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Aldosterone
Spironolactone
Heart Failure
Exercise
Diastolic Heart Failure
Mineralocorticoid Receptors
Patient Selection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Aldosterone inhibition in patients with heart failure with preserved ejection fraction. / Neil, Christopher J A; Singh, Satnam; Frenneaux, Michael.

In: JAMA, Vol. 310, No. 2, 10.07.2013, p. 204.

Research output: Contribution to journalComment/debate

Neil, Christopher J A ; Singh, Satnam ; Frenneaux, Michael. / Aldosterone inhibition in patients with heart failure with preserved ejection fraction. In: JAMA. 2013 ; Vol. 310, No. 2. pp. 204.
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