Almiramide D, cytotoxic peptide from the marine cyanobacterium Oscillatoria nigroviridis

Jairo Quintana, Lina M. Bayona, Leonardo Castellanos, Mónica Puyana, Paola Camargo, Fabio Aristizábal, Christine Edwards, Jioji N. Tabudravu, Marcel Jaspars, Freddy A. Ramos*

*Corresponding author for this work

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Marine benthic cyanobacteria are widely known as a source of toxic and potentially useful compounds. These microorganisms have been studied from many Caribbean locations, which recently include locations in the Colombian Caribbean Sea. In the present study, six lipopeptides named almiramides D to H, together with the known almiramide B are identified from a mat characterized as Oscillatoria nigroviridis collected at the Island of Providence (Colombia, S.W. Caribbean Sea). The most abundant compounds, almiramides B and D were characterized by NMR and HRESIMS, while the structures of the minor compounds almiramides E to H were proposed by the analysis of their HRESIMS and MS<sup>2</sup> spectra. Almiramides B and D were tested against six human cell lines including a gingival fibroblast cell line and five human tumor cell lines (A549, MDA-MB231, MCF-7, HeLa and PC3) showing a strong but not selective toxicity.

Original languageEnglish
Pages (from-to)6789-6795
Number of pages7
JournalBioorganic & Medicinal Chemistry
Volume22
Issue number24
Early online date4 Nov 2014
DOIs
Publication statusPublished - 15 Dec 2014

    Fingerprint

Keywords

  • Almiramides
  • Lipopeptides
  • Marine benthic cyanobacteria
  • Marine natural products
  • Oscillatoria nigroviridis
  • Toxicity against human cell

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Medicine(all)

Cite this

Quintana, J., Bayona, L. M., Castellanos, L., Puyana, M., Camargo, P., Aristizábal, F., ... Ramos, F. A. (2014). Almiramide D, cytotoxic peptide from the marine cyanobacterium Oscillatoria nigroviridis. Bioorganic & Medicinal Chemistry, 22(24), 6789-6795. https://doi.org/10.1016/j.bmc.2014.10.039