TY - JOUR
T1 - Almiramide D, cytotoxic peptide from the marine cyanobacterium Oscillatoria nigroviridis
AU - Quintana, Jairo
AU - Bayona, Lina M.
AU - Castellanos, Leonardo
AU - Puyana, Mónica
AU - Camargo, Paola
AU - Aristizábal, Fabio
AU - Edwards, Christine
AU - Tabudravu, Jioji N.
AU - Jaspars, Marcel
AU - Ramos, Freddy A.
N1 - Acknowledgments
This research was supported by grants from COLCIENCIAS Proyecto1216-452-21241, Universidad Jorge Tadeo Lozano, Universidad Nacional de Colombia sede Bogotá (DIB and Facultad de Ciencias), Fundación para la Promoción de la Investigación y la Tecnología del Banco de la República and Fundación Mariano Ospina Pérez-ICETEX. We want to acknowledge Jerónimo Vásquez, Rafael Barragán and Enrique Pomare for field assistance. The Ministerio de Ambiente, Vivienda y Desarrollo Territorial granted permission for scientific research on biological diversity (permission No. 4 of 10/02/2010).
PY - 2014/12/15
Y1 - 2014/12/15
N2 - Marine benthic cyanobacteria are widely known as a source of toxic and potentially useful compounds. These microorganisms have been studied from many Caribbean locations, which recently include locations in the Colombian Caribbean Sea. In the present study, six lipopeptides named almiramides D to H, together with the known almiramide B are identified from a mat characterized as Oscillatoria nigroviridis collected at the Island of Providence (Colombia, S.W. Caribbean Sea). The most abundant compounds, almiramides B and D were characterized by NMR and HRESIMS, while the structures of the minor compounds almiramides E to H were proposed by the analysis of their HRESIMS and MS2 spectra. Almiramides B and D were tested against six human cell lines including a gingival fibroblast cell line and five human tumor cell lines (A549, MDA-MB231, MCF-7, HeLa and PC3) showing a strong but not selective toxicity.
AB - Marine benthic cyanobacteria are widely known as a source of toxic and potentially useful compounds. These microorganisms have been studied from many Caribbean locations, which recently include locations in the Colombian Caribbean Sea. In the present study, six lipopeptides named almiramides D to H, together with the known almiramide B are identified from a mat characterized as Oscillatoria nigroviridis collected at the Island of Providence (Colombia, S.W. Caribbean Sea). The most abundant compounds, almiramides B and D were characterized by NMR and HRESIMS, while the structures of the minor compounds almiramides E to H were proposed by the analysis of their HRESIMS and MS2 spectra. Almiramides B and D were tested against six human cell lines including a gingival fibroblast cell line and five human tumor cell lines (A549, MDA-MB231, MCF-7, HeLa and PC3) showing a strong but not selective toxicity.
KW - Almiramides
KW - Lipopeptides
KW - Marine benthic cyanobacteria
KW - Marine natural products
KW - Oscillatoria nigroviridis
KW - Toxicity against human cell
UR - http://www.scopus.com/inward/record.url?scp=84913568777&partnerID=8YFLogxK
U2 - 10.1016/j.bmc.2014.10.039
DO - 10.1016/j.bmc.2014.10.039
M3 - Article
C2 - 25468043
AN - SCOPUS:84913568777
VL - 22
SP - 6789
EP - 6795
JO - Bioorganic & Medicinal Chemistry
JF - Bioorganic & Medicinal Chemistry
SN - 0968-0896
IS - 24
ER -
