An appetite for life: brain regulation of hunger and satiety

Lora K Heisler, Daniel D Lam

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Obesity results from the consumption of food in excess of bodily energy requirements, with the excess energy stored as adipose tissue. Sequelae of obesity, such as heart disease and type 2 diabetes, consistently rank among the top causes of death worldwide. The global prevalence of obesity highlights the urgency of understanding the mechanisms regulating hunger and satiety. Appetite, defined as the motivational drive to obtain food, is regulated by a complex neurocircuitry which integrates a variety of interoceptive signals to gauge nutritional state and guide appropriate levels of food-seeking. Here we review key recent developments in the identification of cell groups, neural circuits, endogenous and exogenous substances, and intracellular signaling pathways which drive hunger and satiety. We also consider particularly promising pharmacological targets for appetite modulation.

Original languageEnglish
Pages (from-to)100-106
Number of pages7
JournalCurrent Opinion in Pharmacology
Volume37
Early online date5 Nov 2017
DOIs
Publication statusPublished - Dec 2017

Fingerprint

Hunger
Appetite
Obesity
Food
Brain
Social Identification
Type 2 Diabetes Mellitus
Adipose Tissue
Cause of Death
Heart Diseases
Pharmacology
Drive

Keywords

  • Journal Article
  • Review

Cite this

An appetite for life : brain regulation of hunger and satiety. / Heisler, Lora K; Lam, Daniel D.

In: Current Opinion in Pharmacology, Vol. 37, 12.2017, p. 100-106.

Research output: Contribution to journalReview article

@article{eede601c5cfd43ffa523210d204265ca,
title = "An appetite for life: brain regulation of hunger and satiety",
abstract = "Obesity results from the consumption of food in excess of bodily energy requirements, with the excess energy stored as adipose tissue. Sequelae of obesity, such as heart disease and type 2 diabetes, consistently rank among the top causes of death worldwide. The global prevalence of obesity highlights the urgency of understanding the mechanisms regulating hunger and satiety. Appetite, defined as the motivational drive to obtain food, is regulated by a complex neurocircuitry which integrates a variety of interoceptive signals to gauge nutritional state and guide appropriate levels of food-seeking. Here we review key recent developments in the identification of cell groups, neural circuits, endogenous and exogenous substances, and intracellular signaling pathways which drive hunger and satiety. We also consider particularly promising pharmacological targets for appetite modulation.",
keywords = "Journal Article, Review",
author = "Heisler, {Lora K} and Lam, {Daniel D}",
note = "Acknowledgements: Work was supported by the Wellcome Trust (LKH: WT098012), Biotechnology and Biological Sciences Research Council (LKH: BB/K001418/1, BB/NO17838/1), Medical Research Council (LKH: MC/PC/15077), and Deutsche Forschungsgemeinschaft (DDL: LA 3830/1-1).",
year = "2017",
month = "12",
doi = "10.1016/j.coph.2017.09.002",
language = "English",
volume = "37",
pages = "100--106",
journal = "Current Opinion in Pharmacology",
issn = "1471-4892",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - An appetite for life

T2 - brain regulation of hunger and satiety

AU - Heisler, Lora K

AU - Lam, Daniel D

N1 - Acknowledgements: Work was supported by the Wellcome Trust (LKH: WT098012), Biotechnology and Biological Sciences Research Council (LKH: BB/K001418/1, BB/NO17838/1), Medical Research Council (LKH: MC/PC/15077), and Deutsche Forschungsgemeinschaft (DDL: LA 3830/1-1).

PY - 2017/12

Y1 - 2017/12

N2 - Obesity results from the consumption of food in excess of bodily energy requirements, with the excess energy stored as adipose tissue. Sequelae of obesity, such as heart disease and type 2 diabetes, consistently rank among the top causes of death worldwide. The global prevalence of obesity highlights the urgency of understanding the mechanisms regulating hunger and satiety. Appetite, defined as the motivational drive to obtain food, is regulated by a complex neurocircuitry which integrates a variety of interoceptive signals to gauge nutritional state and guide appropriate levels of food-seeking. Here we review key recent developments in the identification of cell groups, neural circuits, endogenous and exogenous substances, and intracellular signaling pathways which drive hunger and satiety. We also consider particularly promising pharmacological targets for appetite modulation.

AB - Obesity results from the consumption of food in excess of bodily energy requirements, with the excess energy stored as adipose tissue. Sequelae of obesity, such as heart disease and type 2 diabetes, consistently rank among the top causes of death worldwide. The global prevalence of obesity highlights the urgency of understanding the mechanisms regulating hunger and satiety. Appetite, defined as the motivational drive to obtain food, is regulated by a complex neurocircuitry which integrates a variety of interoceptive signals to gauge nutritional state and guide appropriate levels of food-seeking. Here we review key recent developments in the identification of cell groups, neural circuits, endogenous and exogenous substances, and intracellular signaling pathways which drive hunger and satiety. We also consider particularly promising pharmacological targets for appetite modulation.

KW - Journal Article

KW - Review

U2 - 10.1016/j.coph.2017.09.002

DO - 10.1016/j.coph.2017.09.002

M3 - Review article

VL - 37

SP - 100

EP - 106

JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

SN - 1471-4892

ER -