@article{5368e2744aef4c52bcbdf39a8d423f90,
title = "An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology",
abstract = "As heart failure with preserved ejection fraction (HFpEF) rises to epidemic proportions, major steps in patient management and therapeutic development are badly needed. With the current position paper we seek to update our view on HFpEF as a highly complex systemic syndrome, from risk factors and mechanisms to long-term clinical manifestations. We will revise recent advances in animal model development, experimental set-ups and basic and translational science approaches to HFpEF research, highlighting their drawbacks and advantages. Directions are provided for proper model selection as well as for integrative functional evaluation from the in vivo setting to in vitro cell function testing. Additionally, we address new research challenges that require integration of higher-order inter-organ and inter-cell communication to achieve a full systems biology perspective of HFpEF.",
keywords = "Animal models, Experimental evaluation, Heart failure with preserved ejection fraction, Molecular biology, Myocardial function",
author = "Louren{\c c}o, {Andre P.} and Leite-Moreira, {Adelino F.} and Balligand, {Jean Luc} and Johann Bauersachs and Dana Dawson and {de Boer}, {Rudolf A.} and {de Windt}, {Leon J.} and In{\^e}s Falc{\~a}o-Pires and Ricardo Fontes-Carvalho and Stefan Franz and Mauro Giacca and Denise Hilfiker-Kleiner and Emilio Hirsch and Christoph Maack and Manuel Mayr and Burkert Pieske and Thomas Thum and Tocchetti, {Carlo G.} and Brutsaert, {Dirk L.} and Stephane Heymans",
note = "We acknowledge the support from the Netherlands Cardiovascular Research Initiative: {\textquoteleft}An initiative with support of the Dutch Heart Foundation{\textquoteright}, CVON-ARENA. APL, ALM, IFP and RFC, grants from Funda{\c c}{\~a}o para a Ci{\^e}ncia e Tecnologia (PTDC/DTP-PIC/4104/2014 and EXCL/BIM --MEC/0055/2012, financiados por fundos nacionais atrav{\'e}s da FCT - Funda{\c c}{\~a}o para a Ci{\^e}ncia e Tecnologia, I.P. e cofinanciados pelo FEDER - Fundo Europeu de Desenvolvimento Regional, PTDC/DTP-PIC/4104/2014, atrav{\'e}s do COMPETE 2020 - Programa Operacional Fatores de Competitividade), FP7-Health-2010, MEDIA-261409, MINOTAUR, ERA-NET-CVD 2017, {\textquoteleft}Diabetes obesity at the crossroads between Oncological and Cardiovascular diseases - a system analysis NET towards precision medicine (DOCnet){\textquoteright} (NORTE-01 -0145-FEDER-000003) and {\textquoteleft}NEw Targets in DIAstolic heart failure: from co-MOrbidities to persoNalizeD medicine (NETDIAMOND){\textquoteright} (SAICT-PAC/0047/2015; 01/12/2016 to 30/11/2019), grants from EU through the European Regional Development Fund (ERDF), European Structural and Investment Funds (ESIF), under Lisbon Portugal Regional Operational Programme and National Funds through FCT.",
year = "2018",
month = feb,
day = "28",
doi = "10.1002/ejhf.1059",
language = "English",
volume = "20",
pages = "216--227",
journal = "European Journal of Heart Failure",
issn = "1388-9842",
publisher = "Oxford University Press",
number = "2",
}