An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology

Andre P. Lourenço, Adelino F. Leite-Moreira*, Jean Luc Balligand, Johann Bauersachs, Dana Dawson, Rudolf A. de Boer, Leon J. de Windt, Inês Falcão-Pires, Ricardo Fontes-Carvalho, Stefan Franz, Mauro Giacca, Denise Hilfiker-Kleiner, Emilio Hirsch, Christoph Maack, Manuel Mayr, Burkert Pieske, Thomas Thum, Carlo G. Tocchetti, Dirk L. Brutsaert, Stephane Heymans

*Corresponding author for this work

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

As heart failure with preserved ejection fraction (HFpEF) rises to epidemic proportions, major steps in patient management and therapeutic development are badly needed. With the current position paper we seek to update our view on HFpEF as a highly complex systemic syndrome, from risk factors and mechanisms to long-term clinical manifestations. We will revise recent advances in animal model development, experimental set-ups and basic and translational science approaches to HFpEF research, highlighting their drawbacks and advantages. Directions are provided for proper model selection as well as for integrative functional evaluation from the in vivo setting to in vitro cell function testing. Additionally, we address new research challenges that require integration of higher-order inter-organ and inter-cell communication to achieve a full systems biology perspective of HFpEF.

Original languageEnglish
Pages (from-to)216-227
Number of pages12
JournalEuropean Journal of Heart Failure
Volume20
Issue number2
Early online date16 Nov 2017
DOIs
Publication statusPublished - 28 Feb 2018

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Heart Failure
Systems Biology
Research
Cell Communication
Animal Models
Therapeutics

Keywords

  • Animal models
  • Experimental evaluation
  • Heart failure with preserved ejection fraction
  • Molecular biology
  • Myocardial function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

An integrative translational approach to study heart failure with preserved ejection fraction : a position paper from the Working Group on Myocardial Function of the European Society of Cardiology. / Lourenço, Andre P.; Leite-Moreira, Adelino F.; Balligand, Jean Luc; Bauersachs, Johann; Dawson, Dana; de Boer, Rudolf A.; de Windt, Leon J.; Falcão-Pires, Inês; Fontes-Carvalho, Ricardo; Franz, Stefan; Giacca, Mauro; Hilfiker-Kleiner, Denise; Hirsch, Emilio; Maack, Christoph; Mayr, Manuel; Pieske, Burkert; Thum, Thomas; Tocchetti, Carlo G.; Brutsaert, Dirk L.; Heymans, Stephane.

In: European Journal of Heart Failure, Vol. 20, No. 2, 28.02.2018, p. 216-227.

Research output: Contribution to journalArticle

Lourenço, AP, Leite-Moreira, AF, Balligand, JL, Bauersachs, J, Dawson, D, de Boer, RA, de Windt, LJ, Falcão-Pires, I, Fontes-Carvalho, R, Franz, S, Giacca, M, Hilfiker-Kleiner, D, Hirsch, E, Maack, C, Mayr, M, Pieske, B, Thum, T, Tocchetti, CG, Brutsaert, DL & Heymans, S 2018, 'An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology', European Journal of Heart Failure, vol. 20, no. 2, pp. 216-227. https://doi.org/10.1002/ejhf.1059
Lourenço, Andre P. ; Leite-Moreira, Adelino F. ; Balligand, Jean Luc ; Bauersachs, Johann ; Dawson, Dana ; de Boer, Rudolf A. ; de Windt, Leon J. ; Falcão-Pires, Inês ; Fontes-Carvalho, Ricardo ; Franz, Stefan ; Giacca, Mauro ; Hilfiker-Kleiner, Denise ; Hirsch, Emilio ; Maack, Christoph ; Mayr, Manuel ; Pieske, Burkert ; Thum, Thomas ; Tocchetti, Carlo G. ; Brutsaert, Dirk L. ; Heymans, Stephane. / An integrative translational approach to study heart failure with preserved ejection fraction : a position paper from the Working Group on Myocardial Function of the European Society of Cardiology. In: European Journal of Heart Failure. 2018 ; Vol. 20, No. 2. pp. 216-227.
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abstract = "As heart failure with preserved ejection fraction (HFpEF) rises to epidemic proportions, major steps in patient management and therapeutic development are badly needed. With the current position paper we seek to update our view on HFpEF as a highly complex systemic syndrome, from risk factors and mechanisms to long-term clinical manifestations. We will revise recent advances in animal model development, experimental set-ups and basic and translational science approaches to HFpEF research, highlighting their drawbacks and advantages. Directions are provided for proper model selection as well as for integrative functional evaluation from the in vivo setting to in vitro cell function testing. Additionally, we address new research challenges that require integration of higher-order inter-organ and inter-cell communication to achieve a full systems biology perspective of HFpEF.",
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AU - Leite-Moreira, Adelino F.

AU - Balligand, Jean Luc

AU - Bauersachs, Johann

AU - Dawson, Dana

AU - de Boer, Rudolf A.

AU - de Windt, Leon J.

AU - Falcão-Pires, Inês

AU - Fontes-Carvalho, Ricardo

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AU - Mayr, Manuel

AU - Pieske, Burkert

AU - Thum, Thomas

AU - Tocchetti, Carlo G.

AU - Brutsaert, Dirk L.

AU - Heymans, Stephane

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