An Invertebrate Host to Study Fungal Infections, Mycotoxins and Antifungal Drugs: Tenebrio molitor

Patrícia Canteri de Souza, Carla Custódio Caloni, Duncan Wilson, Ricardo Sergio Almeida

Research output: Contribution to journalReview article

4 Citations (Scopus)
5 Downloads (Pure)

Abstract

Faced with ethical conflict and social pressure, researchers have increasingly chosen to use alternative models over vertebrates in their research. Since the innate immune system is evolutionarily conserved in insects, the use of these animals in research is gaining ground. This review discusses Tenebrio molitor as a potential model host for the study of pathogenic fungi. Larvae of T. molitor are known as cereal pests and, in addition, are widely used as animal and human feed. A number of studies on mechanisms of the humoral system, especially in the synthesis of antimicrobial peptides, which have similar characteristics to vertebrates, have been performed. These studies demonstrate the potential of T. molitor larvae as a model host that can be used to study fungal virulence, mycotoxin effects, host immune responses to fungal infection, and the action of antifungal compounds.

Original languageEnglish
Article number125
JournalJournal of Fungi
Volume4
Issue number4
DOIs
Publication statusPublished - 12 Nov 2018

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Tenebrio
Mycoses
Mycotoxins
Invertebrates
Larva
Vertebrates
Pharmaceutical Preparations
Virulence
Insects
Immune System
Fungi
Research Personnel
Pressure
Peptides
Research
Edible Grain

Keywords

  • alternative method of infection
  • candida spp.
  • cryptococcus spp.
  • invertebrate host model
  • mycotoxins
  • innate immunity
  • hemocytes
  • mealworm
  • tenecin
  • fungal infection

Cite this

Canteri de Souza, P., Custódio Caloni, C., Wilson, D., & Sergio Almeida, R. (2018). An Invertebrate Host to Study Fungal Infections, Mycotoxins and Antifungal Drugs: Tenebrio molitor. Journal of Fungi, 4(4), [125]. https://doi.org/10.3390/jof4040125

An Invertebrate Host to Study Fungal Infections, Mycotoxins and Antifungal Drugs : Tenebrio molitor. / Canteri de Souza, Patrícia; Custódio Caloni, Carla; Wilson, Duncan; Sergio Almeida, Ricardo.

In: Journal of Fungi, Vol. 4, No. 4, 125, 12.11.2018.

Research output: Contribution to journalReview article

Canteri de Souza, P, Custódio Caloni, C, Wilson, D & Sergio Almeida, R 2018, 'An Invertebrate Host to Study Fungal Infections, Mycotoxins and Antifungal Drugs: Tenebrio molitor', Journal of Fungi, vol. 4, no. 4, 125. https://doi.org/10.3390/jof4040125
Canteri de Souza, Patrícia ; Custódio Caloni, Carla ; Wilson, Duncan ; Sergio Almeida, Ricardo. / An Invertebrate Host to Study Fungal Infections, Mycotoxins and Antifungal Drugs : Tenebrio molitor. In: Journal of Fungi. 2018 ; Vol. 4, No. 4.
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