An Investigation into the protein composition of the teneral Glossina morsitans morsitans peritrophic matrix

Clair Rose; Rodrigo Belmonte; Stuart D Armstrong; Gemma Molyneux; Lee R Haines; Michael J Lehane; Jonathan Wastling; Alvaro Acosta-Serrano

doi:10.1371/journal.pntd.0002691

An Investigation into the protein composition of the teneral Glossina morsitans morsitans peritrophic matrix

Clair Rose, Rodrigo Belmonte, Stuart D Armstrong, Gemma Molyneux, Lee R Haines, Michael J Lehane, Jonathan Wastling, Alvaro Acosta-Serrano

Medical Sciences

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Abstract

Tsetse flies serve as biological vectors for several species of African trypanosomes. In order to survive, proliferate and establish a midgut infection, trypanosomes must cross the tsetse fly peritrophic matrix (PM), which is an acellular gut lining surrounding the blood meal. Crossing of this multi-layered structure occurs at least twice during parasite migration and development, but the mechanism of how trypanosomes do so is not understood. In order to better comprehend the molecular events surrounding trypanosome penetration of the tsetse PM, a mass spectrometry-based approach was applied to investigate the PM protein composition using Glossina morsitans morsitans as a model organism.

Original language	English
Article number	e2691
Number of pages	12
Journal	PLoS Neglected Tropical Diseases
Volume	8
Issue number	4
DOIs	https://doi.org/10.1371/journal.pntd.0002691
Publication status	Published - 24 Apr 2014

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An investigation into the protein
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abstract = "Tsetse flies serve as biological vectors for several species of African trypanosomes. In order to survive, proliferate and establish a midgut infection, trypanosomes must cross the tsetse fly peritrophic matrix (PM), which is an acellular gut lining surrounding the blood meal. Crossing of this multi-layered structure occurs at least twice during parasite migration and development, but the mechanism of how trypanosomes do so is not understood. In order to better comprehend the molecular events surrounding trypanosome penetration of the tsetse PM, a mass spectrometry-based approach was applied to investigate the PM protein composition using Glossina morsitans morsitans as a model organism.",

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AU - Molyneux, Gemma

AU - Haines, Lee R

AU - Lehane, Michael J

AU - Wastling, Jonathan

AU - Acosta-Serrano, Alvaro

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AB - Tsetse flies serve as biological vectors for several species of African trypanosomes. In order to survive, proliferate and establish a midgut infection, trypanosomes must cross the tsetse fly peritrophic matrix (PM), which is an acellular gut lining surrounding the blood meal. Crossing of this multi-layered structure occurs at least twice during parasite migration and development, but the mechanism of how trypanosomes do so is not understood. In order to better comprehend the molecular events surrounding trypanosome penetration of the tsetse PM, a mass spectrometry-based approach was applied to investigate the PM protein composition using Glossina morsitans morsitans as a model organism.

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An Investigation into the protein composition of the teneral Glossina morsitans morsitans peritrophic matrix

Abstract

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