Analysis of interleukin-4 receptor alpha chain variants in multiple sclerosis

H. Hackstein, A. Bitsch, A. Bohnert, H. Hofmann, F. Weber, A. Ohly, Christopher Linington, M. Maurer, S. Poser, P. Rieckmam, G. Bein

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    A recent candidate gene study employing microsatellite markers suggested a possible linkage of multiple sclerosis (MS) with the interleukin-4 receptor (IL4R) gene. Consequently, we investigated the association of different IL4R variants with MS in 341 german MS patients and 305 healthy controls. Analysis of the first 100 MS patients for six IL4R variants showed an increased frequency of the R551 variant in MS patients versus healthy controls and carriage of the same IL4R variant was weakly associated with myelin oligodendrocyte glycoprotein (MOG) autoantibody production. However, further analysis of all 341 MS patients did not confirm the finding that this IL4R variant represents a general genetic risk factor for MS but revealed an increased frequency of the R551 Variant in MS patients with primary progressive MS (PPMS, n=48) as compared to patients with relapsing remitting MS or secondary progressive MS (RR/SPMS n=284; P=0.005 for genotype differences) and to 305 healthy controls (P=0.001 for genotype differences). This association was statistically independent of the presence of the well-known MS susceptibility allele HLA-DRB1*15. After correction for multiple comparisons only the genotype differences between PPMS patients and healthy controls remained statistically significant. These results indicate, that the IL4R variant R551 may influence the genetic predisposition for PPMS but does not represent a general genetic risk factor for MS. (C) 2001 Elsevier Science B.V. All rights reserved.

    Original languageEnglish
    Pages (from-to)240-248
    Number of pages8
    JournalJournal of Neuroimmunology
    Volume113
    DOIs
    Publication statusPublished - 2001

    Keywords

    • human IL-4 receptor
    • multiple sclerosis
    • MOG autoantibodies
    • MYELIN OLIGODENDROCYTE GLYCOPROTEIN
    • EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
    • GENOME SCREEN
    • MEDIATED DEMYELINATION
    • SIGNAL-TRANSDUCTION
    • TH2 CELLS
    • ASSOCIATION
    • DISEASE
    • ATOPY
    • GENE

    Cite this

    Hackstein, H., Bitsch, A., Bohnert, A., Hofmann, H., Weber, F., Ohly, A., ... Bein, G. (2001). Analysis of interleukin-4 receptor alpha chain variants in multiple sclerosis. Journal of Neuroimmunology, 113, 240-248. https://doi.org/10.1016/S0165-5728(00)00455-0

    Analysis of interleukin-4 receptor alpha chain variants in multiple sclerosis. / Hackstein, H.; Bitsch, A.; Bohnert, A.; Hofmann, H.; Weber, F.; Ohly, A.; Linington, Christopher; Maurer, M.; Poser, S.; Rieckmam, P.; Bein, G.

    In: Journal of Neuroimmunology, Vol. 113, 2001, p. 240-248.

    Research output: Contribution to journalArticle

    Hackstein, H, Bitsch, A, Bohnert, A, Hofmann, H, Weber, F, Ohly, A, Linington, C, Maurer, M, Poser, S, Rieckmam, P & Bein, G 2001, 'Analysis of interleukin-4 receptor alpha chain variants in multiple sclerosis', Journal of Neuroimmunology, vol. 113, pp. 240-248. https://doi.org/10.1016/S0165-5728(00)00455-0
    Hackstein, H. ; Bitsch, A. ; Bohnert, A. ; Hofmann, H. ; Weber, F. ; Ohly, A. ; Linington, Christopher ; Maurer, M. ; Poser, S. ; Rieckmam, P. ; Bein, G. / Analysis of interleukin-4 receptor alpha chain variants in multiple sclerosis. In: Journal of Neuroimmunology. 2001 ; Vol. 113. pp. 240-248.
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    abstract = "A recent candidate gene study employing microsatellite markers suggested a possible linkage of multiple sclerosis (MS) with the interleukin-4 receptor (IL4R) gene. Consequently, we investigated the association of different IL4R variants with MS in 341 german MS patients and 305 healthy controls. Analysis of the first 100 MS patients for six IL4R variants showed an increased frequency of the R551 variant in MS patients versus healthy controls and carriage of the same IL4R variant was weakly associated with myelin oligodendrocyte glycoprotein (MOG) autoantibody production. However, further analysis of all 341 MS patients did not confirm the finding that this IL4R variant represents a general genetic risk factor for MS but revealed an increased frequency of the R551 Variant in MS patients with primary progressive MS (PPMS, n=48) as compared to patients with relapsing remitting MS or secondary progressive MS (RR/SPMS n=284; P=0.005 for genotype differences) and to 305 healthy controls (P=0.001 for genotype differences). This association was statistically independent of the presence of the well-known MS susceptibility allele HLA-DRB1*15. After correction for multiple comparisons only the genotype differences between PPMS patients and healthy controls remained statistically significant. These results indicate, that the IL4R variant R551 may influence the genetic predisposition for PPMS but does not represent a general genetic risk factor for MS. (C) 2001 Elsevier Science B.V. All rights reserved.",
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    T1 - Analysis of interleukin-4 receptor alpha chain variants in multiple sclerosis

    AU - Hackstein, H.

    AU - Bitsch, A.

    AU - Bohnert, A.

    AU - Hofmann, H.

    AU - Weber, F.

    AU - Ohly, A.

    AU - Linington, Christopher

    AU - Maurer, M.

    AU - Poser, S.

    AU - Rieckmam, P.

    AU - Bein, G.

    PY - 2001

    Y1 - 2001

    N2 - A recent candidate gene study employing microsatellite markers suggested a possible linkage of multiple sclerosis (MS) with the interleukin-4 receptor (IL4R) gene. Consequently, we investigated the association of different IL4R variants with MS in 341 german MS patients and 305 healthy controls. Analysis of the first 100 MS patients for six IL4R variants showed an increased frequency of the R551 variant in MS patients versus healthy controls and carriage of the same IL4R variant was weakly associated with myelin oligodendrocyte glycoprotein (MOG) autoantibody production. However, further analysis of all 341 MS patients did not confirm the finding that this IL4R variant represents a general genetic risk factor for MS but revealed an increased frequency of the R551 Variant in MS patients with primary progressive MS (PPMS, n=48) as compared to patients with relapsing remitting MS or secondary progressive MS (RR/SPMS n=284; P=0.005 for genotype differences) and to 305 healthy controls (P=0.001 for genotype differences). This association was statistically independent of the presence of the well-known MS susceptibility allele HLA-DRB1*15. After correction for multiple comparisons only the genotype differences between PPMS patients and healthy controls remained statistically significant. These results indicate, that the IL4R variant R551 may influence the genetic predisposition for PPMS but does not represent a general genetic risk factor for MS. (C) 2001 Elsevier Science B.V. All rights reserved.

    AB - A recent candidate gene study employing microsatellite markers suggested a possible linkage of multiple sclerosis (MS) with the interleukin-4 receptor (IL4R) gene. Consequently, we investigated the association of different IL4R variants with MS in 341 german MS patients and 305 healthy controls. Analysis of the first 100 MS patients for six IL4R variants showed an increased frequency of the R551 variant in MS patients versus healthy controls and carriage of the same IL4R variant was weakly associated with myelin oligodendrocyte glycoprotein (MOG) autoantibody production. However, further analysis of all 341 MS patients did not confirm the finding that this IL4R variant represents a general genetic risk factor for MS but revealed an increased frequency of the R551 Variant in MS patients with primary progressive MS (PPMS, n=48) as compared to patients with relapsing remitting MS or secondary progressive MS (RR/SPMS n=284; P=0.005 for genotype differences) and to 305 healthy controls (P=0.001 for genotype differences). This association was statistically independent of the presence of the well-known MS susceptibility allele HLA-DRB1*15. After correction for multiple comparisons only the genotype differences between PPMS patients and healthy controls remained statistically significant. These results indicate, that the IL4R variant R551 may influence the genetic predisposition for PPMS but does not represent a general genetic risk factor for MS. (C) 2001 Elsevier Science B.V. All rights reserved.

    KW - human IL-4 receptor

    KW - multiple sclerosis

    KW - MOG autoantibodies

    KW - MYELIN OLIGODENDROCYTE GLYCOPROTEIN

    KW - EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

    KW - GENOME SCREEN

    KW - MEDIATED DEMYELINATION

    KW - SIGNAL-TRANSDUCTION

    KW - TH2 CELLS

    KW - ASSOCIATION

    KW - DISEASE

    KW - ATOPY

    KW - GENE

    U2 - 10.1016/S0165-5728(00)00455-0

    DO - 10.1016/S0165-5728(00)00455-0

    M3 - Article

    VL - 113

    SP - 240

    EP - 248

    JO - Journal of Neuroimmunology

    JF - Journal of Neuroimmunology

    SN - 0165-5728

    ER -