Analysis of musculoskeletal and breast tumours by fast field-cycling MRI

Lionel Broche; George Patrick Ashcroft; David Boddie; Sinclair Dundas; Tanja Gagliardi; Steven Darryll Heys; David John Lurie; Teena McKenzie; Iain Miller; Peter James Ross

Analysis of musculoskeletal and breast tumours by fast field-cycling MRI

Lionel Broche, George Patrick Ashcroft, David Boddie, Sinclair Dundas, Tanja Gagliardi, Steven Darryll Heys, David John Lurie, Teena McKenzie, Iain Miller, Peter James Ross

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Abstract

Fast-field cycling MRI (FFC-MRI) is a new imaging technique that allows varying the main magnetic field during a scan in order to explore tissue properties over several decades of magnetic field strength. This technique opens up many possibilities for new molecular-based contrast in images and benefits from active research in NMR that has shown its great versatility. In particular, field-cycling allows non-invasive and contrast-agent-free detection of certain immobile proteins thanks to cross-relaxation effects between water protons and 14N, which is already being used in other studies. It is also possible to measure the evolution of T1 with the magnetic field strength and the dispersion curve obtained provides information at molecular scale.
Here we present the results of a pilot study that aimed to exploit the molecular information provided by FFC-MRI in order to analyse the contrast obtained ex vivo from tumours extracted from human musculoskeletal or breast tissues.

ESMRMB (European Society for Magnetic Resonance in Medicine and Biology)

Original language	English
Publication status	Published - 4 Oct 2013
Event	ESMRMB 2013 Congress - Centre de Congres Pierre Baudis, Toulouse, France Duration: 3 Oct 2013 → 5 Oct 2013

Conference

Conference	ESMRMB 2013 Congress
Country/Territory	France
City	Toulouse
Period	3/10/13 → 5/10/13

Keywords

Cancer detection and characterisation
Quadrupolar coupling
Pilot study
Fast field-cycling NMR

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Cite this

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title = "Analysis of musculoskeletal and breast tumours by fast field-cycling MRI",

abstract = "Fast-field cycling MRI (FFC-MRI) is a new imaging technique that allows varying the main magnetic field during a scan in order to explore tissue properties over several decades of magnetic field strength. This technique opens up many possibilities for new molecular-based contrast in images and benefits from active research in NMR that has shown its great versatility. In particular, field-cycling allows non-invasive and contrast-agent-free detection of certain immobile proteins thanks to cross-relaxation effects between water protons and 14N, which is already being used in other studies. It is also possible to measure the evolution of T1 with the magnetic field strength and the dispersion curve obtained provides information at molecular scale. Here we present the results of a pilot study that aimed to exploit the molecular information provided by FFC-MRI in order to analyse the contrast obtained ex vivo from tumours extracted from human musculoskeletal or breast tissues.ESMRMB (European Society for Magnetic Resonance in Medicine and Biology)",

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language = "English",

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T1 - Analysis of musculoskeletal and breast tumours by fast field-cycling MRI

AU - Broche, Lionel

AU - Ashcroft, George Patrick

AU - Boddie, David

AU - Dundas, Sinclair

AU - Gagliardi, Tanja

AU - Heys, Steven Darryll

AU - Lurie, David John

AU - McKenzie, Teena

AU - Miller, Iain

AU - Ross, Peter James

PY - 2013/10/4

Y1 - 2013/10/4

N2 - Fast-field cycling MRI (FFC-MRI) is a new imaging technique that allows varying the main magnetic field during a scan in order to explore tissue properties over several decades of magnetic field strength. This technique opens up many possibilities for new molecular-based contrast in images and benefits from active research in NMR that has shown its great versatility. In particular, field-cycling allows non-invasive and contrast-agent-free detection of certain immobile proteins thanks to cross-relaxation effects between water protons and 14N, which is already being used in other studies. It is also possible to measure the evolution of T1 with the magnetic field strength and the dispersion curve obtained provides information at molecular scale. Here we present the results of a pilot study that aimed to exploit the molecular information provided by FFC-MRI in order to analyse the contrast obtained ex vivo from tumours extracted from human musculoskeletal or breast tissues.ESMRMB (European Society for Magnetic Resonance in Medicine and Biology)

AB - Fast-field cycling MRI (FFC-MRI) is a new imaging technique that allows varying the main magnetic field during a scan in order to explore tissue properties over several decades of magnetic field strength. This technique opens up many possibilities for new molecular-based contrast in images and benefits from active research in NMR that has shown its great versatility. In particular, field-cycling allows non-invasive and contrast-agent-free detection of certain immobile proteins thanks to cross-relaxation effects between water protons and 14N, which is already being used in other studies. It is also possible to measure the evolution of T1 with the magnetic field strength and the dispersion curve obtained provides information at molecular scale. Here we present the results of a pilot study that aimed to exploit the molecular information provided by FFC-MRI in order to analyse the contrast obtained ex vivo from tumours extracted from human musculoskeletal or breast tissues.ESMRMB (European Society for Magnetic Resonance in Medicine and Biology)

KW - Cancer detection and characterisation

KW - Quadrupolar coupling

KW - Pilot study

KW - Fast field-cycling NMR

M3 - Abstract

T2 - ESMRMB 2013 Congress

Y2 - 3 October 2013 through 5 October 2013

ER -

Analysis of musculoskeletal and breast tumours by fast field-cycling MRI

Abstract

Conference

Keywords

UN SDGs

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