Analysis of musculoskeletal and breast tumours by fast field-cycling MRI

Lionel Broche, George Patrick Ashcroft, David Boddie, Sinclair Dundas, Tanja Gagliardi, Steven Darryll Heys, David John Lurie, Teena McKenzie, Iain Miller, Peter James Ross

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Abstract

Fast-field cycling MRI (FFC-MRI) is a new imaging technique that allows varying the main magnetic field during a scan in order to explore tissue properties over several decades of magnetic field strength. This technique opens up many possibilities for new molecular-based contrast in images and benefits from active research in NMR that has shown its great versatility. In particular, field-cycling allows non-invasive and contrast-agent-free detection of certain immobile proteins thanks to cross-relaxation effects between water protons and 14N, which is already being used in other studies. It is also possible to measure the evolution of T1 with the magnetic field strength and the dispersion curve obtained provides information at molecular scale.
Here we present the results of a pilot study that aimed to exploit the molecular information provided by FFC-MRI in order to analyse the contrast obtained ex vivo from tumours extracted from human musculoskeletal or breast tissues.

ESMRMB (European Society for Magnetic Resonance in Medicine and Biology)
Original languageEnglish
Publication statusPublished - 4 Oct 2013
EventESMRMB 2013 Congress - Centre de Congres Pierre Baudis, Toulouse, France
Duration: 3 Oct 20135 Oct 2013

Conference

ConferenceESMRMB 2013 Congress
CountryFrance
CityToulouse
Period3/10/135/10/13

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Keywords

  • Cancer detection and characterisation
  • Quadrupolar coupling
  • Pilot study
  • Fast field-cycling NMR

Cite this

Broche, L., Ashcroft, G. P., Boddie, D., Dundas, S., Gagliardi, T., Heys, S. D., ... Ross, P. J. (2013). Analysis of musculoskeletal and breast tumours by fast field-cycling MRI. Abstract from ESMRMB 2013 Congress, Toulouse, France.