Abstract
Background
Small studies suggest an association between ANCA-associated vasculitis (AAV) incidence and rurality, seasonality and socioeconomic deprivation. We examined the incidence of kidney biopsy-proven AAV and its relationship with these factors in the adult Scottish population.
Methods
Using the Scottish Renal Biopsy Registry, all adult native kidney biopsies performed between 2014 and 2018 with a diagnosis of granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) were identified. The Scottish Government Urban Rural Classification was used for rurality analysis. Seasons were defined as autumn (September-November), winter (December-February), spring (March-May) and summer (June-August). Patients were separated into quintiles of socioeconomic deprivation using the validated Scottish Index of Multiple Deprivation and incidence standardised to age. Estimated glomerular filtration rate and urine protein:creatinine ratio at time of biopsy were used to assess disease severity.
Results
339 cases of renal AAV were identified, of which 62% had MPA and 38% had GPA diagnosis. AAV incidence was 15.1 per million population per year (pmp/year). Mean age was 66 years and 54% were female. Incidence of GPA (but not MPA) was positively associated with rurality (5.2, 8.4 and 9.1 pmp/year in 'urban', 'accessible remote' and 'rural remote' areas, respectively; p=0.04). The age-standardised incidence ratio was similar across all quintiles of deprivation (p=ns).
Conclusions
Seasonality and disease severity did not vary across AAV study groups. In this complete national cohort study, we observed a positive association between kidney biopsy-proven GPA and rurality.
| Original language | English |
|---|---|
| Article number | 001555 |
| Number of pages | 8 |
| Journal | RMD Open |
| Volume | 7 |
| Issue number | 2 |
| Early online date | 19 Apr 2021 |
| DOIs | |
| Publication status | Published - 19 Apr 2021 |
Bibliographical note
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.Data Availability Statement
Data described in the manuscript is available on reasonable request. Further information, including the procedures for obtaining and accessing data is found from https://www.ndc.scot.nhs.uk/National-Datasets/data.asp?SubID=15Keywords
- granulomatosis with polyangiitis
- autoimmune diseases
- epidemiology
- immune system diseases
- systemic vasculitis
Access to Document
- Aiyegbsi_et_al_ANCA_associated_RMD_Open_vor
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