TY - JOUR
T1 - Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria
AU - Diyaolu, Oluwatofunmilayo A.
AU - Preet, Gagan
AU - Fagbemi, Adeshola A.
AU - Annang, F
AU - Pérez-Moreno, Guiomar
AU - Bosch-Navarrete, Cristina
AU - Adebisi, Olusoji O.
AU - Oluwabusola, Emmanuel Tope
AU - Milne, Bruce F.
AU - Jaspars, Marcel
AU - Ebel, Rainer
N1 - This article belongs to the Special Issue Antimicrobial and Anti-infective Activity of Natural Products.
The authors are grateful to the Schlumberger Foundation Faculty for the Future board for their financial support in conducting the present study.
PY - 2023/1
Y1 - 2023/1
N2 - In this study, we explored a fungal strain UIAU-3F identified as Aspergillus fumigatus isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in three different fermentation media, which resulted in different chemical profiles, evidenced by LC-ESI-MS-based metabolomics and multivariate analysis. The methanolic extract afforded two known compounds, fumitremorgin C (1) and pseurotin D (2). The in vitro antiparasitic assays of 1 against Trypanosoma cruzi and Plasmodium falciparum showed moderate activity with IC50 values of 9.6 µM and 2.3 µM, respectively, while 2 displayed IC50 values > 50 µM. Molecular docking analysis was performed on major protein targets to better understand the potential mechanism of the antitrypanosomal and antiplasmodial activities of the two known compounds.
AB - In this study, we explored a fungal strain UIAU-3F identified as Aspergillus fumigatus isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in three different fermentation media, which resulted in different chemical profiles, evidenced by LC-ESI-MS-based metabolomics and multivariate analysis. The methanolic extract afforded two known compounds, fumitremorgin C (1) and pseurotin D (2). The in vitro antiparasitic assays of 1 against Trypanosoma cruzi and Plasmodium falciparum showed moderate activity with IC50 values of 9.6 µM and 2.3 µM, respectively, while 2 displayed IC50 values > 50 µM. Molecular docking analysis was performed on major protein targets to better understand the potential mechanism of the antitrypanosomal and antiplasmodial activities of the two known compounds.
KW - aspergillus fumigatus
KW - OSMAC
KW - Metabolomics
KW - molecular docking
KW - antitrypanosomal
KW - antiplasmodial
KW - insilico molecular docking
UR - https://www.mdpi.com/2079-6382/12/1/109
U2 - 10.3390/antibiotics12010109
DO - 10.3390/antibiotics12010109
M3 - Article
C2 - 36671310
VL - 12
JO - Antibiotics
JF - Antibiotics
SN - 2079-6382
IS - 1
M1 - 109
ER -