Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria

Oluwatofunmilayo A. Diyaolu; Gagan Preet; Adeshola A. Fagbemi; F Annang; Guiomar Pérez-Moreno; Cristina Bosch-Navarrete; Olusoji O. Adebisi; Emmanuel Tope Oluwabusola; Bruce F. Milne; Marcel Jaspars; Rainer Ebel

doi:10.3390/antibiotics12010109

Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria

Oluwatofunmilayo A. Diyaolu^* (Corresponding Author), Gagan Preet, Adeshola A. Fagbemi, F Annang, Guiomar Pérez-Moreno, Cristina Bosch-Navarrete, Olusoji O. Adebisi, Emmanuel Tope Oluwabusola, Bruce F. Milne, Marcel Jaspars, Rainer Ebel

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

In this study, we explored a fungal strain UIAU-3F identified as Aspergillus fumigatus isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in three different fermentation media, which resulted in different chemical profiles, evidenced by LC-ESI-MS-based metabolomics and multivariate analysis. The methanolic extract afforded two known compounds, fumitremorgin C (1) and pseurotin D (2). The in vitro antiparasitic assays of 1 against Trypanosoma cruzi and Plasmodium falciparum showed moderate activity with IC50 values of 9.6 µM and 2.3 µM, respectively, while 2 displayed IC50 values > 50 µM. Molecular docking analysis was performed on major protein targets to better understand the potential mechanism of the antitrypanosomal and antiplasmodial activities of the two known compounds.

Original language	English
Article number	109
Number of pages	16
Journal	Antibiotics
Volume	12
Issue number	1
DOIs	https://doi.org/10.3390/antibiotics12010109
Publication status	Published - Jan 2023

Bibliographical note

This article belongs to the Special Issue Antimicrobial and Anti-infective Activity of Natural Products.

The authors are grateful to the Schlumberger Foundation Faculty for the Future board for their financial support in conducting the present study.

Data Availability Statement

Not applicable.

Keywords

aspergillus fumigatus
OSMAC
Metabolomics
molecular docking
antitrypanosomal
antiplasmodial
insilico molecular docking

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Diyaolu _etal_antibioticsAntiparasitic_Activities_Compounds_VOR
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Final published version, 3.6 MBLicence: CC BY

Cite this

Diyaolu, O. A., Preet, G., Fagbemi, A. A., Annang, F., Pérez-Moreno, G., Bosch-Navarrete, C., Adebisi, O. O., Oluwabusola, E. T., Milne, B. F., Jaspars, M., & Ebel, R. (2023). Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria. Antibiotics, 12(1), Article 109. https://doi.org/10.3390/antibiotics12010109

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abstract = "In this study, we explored a fungal strain UIAU-3F identified as Aspergillus fumigatus isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in three different fermentation media, which resulted in different chemical profiles, evidenced by LC-ESI-MS-based metabolomics and multivariate analysis. The methanolic extract afforded two known compounds, fumitremorgin C (1) and pseurotin D (2). The in vitro antiparasitic assays of 1 against Trypanosoma cruzi and Plasmodium falciparum showed moderate activity with IC50 values of 9.6 µM and 2.3 µM, respectively, while 2 displayed IC50 values > 50 µM. Molecular docking analysis was performed on major protein targets to better understand the potential mechanism of the antitrypanosomal and antiplasmodial activities of the two known compounds.",

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AU - Jaspars, Marcel

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N2 - In this study, we explored a fungal strain UIAU-3F identified as Aspergillus fumigatus isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in three different fermentation media, which resulted in different chemical profiles, evidenced by LC-ESI-MS-based metabolomics and multivariate analysis. The methanolic extract afforded two known compounds, fumitremorgin C (1) and pseurotin D (2). The in vitro antiparasitic assays of 1 against Trypanosoma cruzi and Plasmodium falciparum showed moderate activity with IC50 values of 9.6 µM and 2.3 µM, respectively, while 2 displayed IC50 values > 50 µM. Molecular docking analysis was performed on major protein targets to better understand the potential mechanism of the antitrypanosomal and antiplasmodial activities of the two known compounds.

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Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria

Abstract

Bibliographical note

Data Availability Statement

Keywords

Access to Document

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Fingerprint

Marine Biodiscovery Centre

Cite this

Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria

Abstract

Bibliographical note

Data Availability Statement

Keywords

Access to Document

Other files and links

Fingerprint

Equipment

Marine Biodiscovery Centre

Cite this