Background: Novel analytical frameworks to assess ecology and predictive function of the microbiome are now available. Postsurgical recurrence of IBD and treatment-naïve pediatric IBD are key populations to elucidate microbiome changes associated with the development of IBD. Our aims were to assess the community structure of the mucosa-associated microbiota of 'de novo' intestinal inflammation post-pouch surgery as well as treatment-naïve pediatric IBD and pediatric controls and to perform functional prediction of altered metabolic pathways.
- Pouch Surgery
- Benzoate metabolism
Connors, J., Hansen, R., Dunn, K. A., Langille, M. G., Russell, R. K., Otley, A. R., ... Van Limbergen, J. (2015). Assessment of community structure and predictive functional profiling of the mucosa-associated microbiome implicates alterations in benzoate metabolism in 'de novo' IBD after pouch-surgery and in treatment-naive pediatric IBD. Journal of Crohn's and Colitis, 9(Suppl. 1), S439. https://doi.org/10.1093/ecco-jcc/jju027.833