Assessment of community structure and predictive functional profiling of the mucosa-associated microbiome implicates alterations in benzoate metabolism in 'de novo' IBD after pouch-surgery and in treatment-naive pediatric IBD

J. Connors, R. Hansen, K. A. Dunn, M. G. Langille, R. K. Russell, A. R. Otley, B. MacIntyre, E. El-Omar, J. P. Bielawski, G. L. Hold, J. Van Limbergen

Research output: Contribution to journalAbstract

25 Citations (Scopus)

Abstract

Background: Novel analytical frameworks to assess ecology and predictive function of the microbiome are now available. Postsurgical recurrence of IBD and treatment-naïve pediatric IBD are key populations to elucidate microbiome changes associated with the development of IBD. Our aims were to assess the community structure of the mucosa-associated microbiota of 'de novo' intestinal inflammation post-pouch surgery as well as treatment-naïve pediatric IBD and pediatric controls and to perform functional prediction of altered metabolic pathways.
Original languageEnglish
Pages (from-to)S439
Number of pages1
JournalJournal of Crohn's and Colitis
Volume9
Issue numberSuppl. 1
DOIs
Publication statusPublished - Feb 2015

Keywords

  • IBD
  • Pouch Surgery
  • Benzoate metabolism

Cite this

Assessment of community structure and predictive functional profiling of the mucosa-associated microbiome implicates alterations in benzoate metabolism in 'de novo' IBD after pouch-surgery and in treatment-naive pediatric IBD. / Connors, J.; Hansen, R.; Dunn, K. A.; Langille, M. G.; Russell, R. K.; Otley, A. R.; MacIntyre, B.; El-Omar, E.; Bielawski, J. P.; Hold, G. L.; Van Limbergen, J.

In: Journal of Crohn's and Colitis, Vol. 9, No. Suppl. 1, 02.2015, p. S439.

Research output: Contribution to journalAbstract

Connors, J. ; Hansen, R. ; Dunn, K. A. ; Langille, M. G. ; Russell, R. K. ; Otley, A. R. ; MacIntyre, B. ; El-Omar, E. ; Bielawski, J. P. ; Hold, G. L. ; Van Limbergen, J. / Assessment of community structure and predictive functional profiling of the mucosa-associated microbiome implicates alterations in benzoate metabolism in 'de novo' IBD after pouch-surgery and in treatment-naive pediatric IBD. In: Journal of Crohn's and Colitis. 2015 ; Vol. 9, No. Suppl. 1. pp. S439.
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abstract = "Background: Novel analytical frameworks to assess ecology and predictive function of the microbiome are now available. Postsurgical recurrence of IBD and treatment-na{\"i}ve pediatric IBD are key populations to elucidate microbiome changes associated with the development of IBD. Our aims were to assess the community structure of the mucosa-associated microbiota of 'de novo' intestinal inflammation post-pouch surgery as well as treatment-na{\"i}ve pediatric IBD and pediatric controls and to perform functional prediction of altered metabolic pathways.",
keywords = "IBD, Pouch Surgery, Benzoate metabolism",
author = "J. Connors and R. Hansen and Dunn, {K. A.} and Langille, {M. G.} and Russell, {R. K.} and Otley, {A. R.} and B. MacIntyre and E. El-Omar and Bielawski, {J. P.} and Hold, {G. L.} and {Van Limbergen}, J.",
year = "2015",
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T1 - Assessment of community structure and predictive functional profiling of the mucosa-associated microbiome implicates alterations in benzoate metabolism in 'de novo' IBD after pouch-surgery and in treatment-naive pediatric IBD

AU - Connors, J.

AU - Hansen, R.

AU - Dunn, K. A.

AU - Langille, M. G.

AU - Russell, R. K.

AU - Otley, A. R.

AU - MacIntyre, B.

AU - El-Omar, E.

AU - Bielawski, J. P.

AU - Hold, G. L.

AU - Van Limbergen, J.

PY - 2015/2

Y1 - 2015/2

N2 - Background: Novel analytical frameworks to assess ecology and predictive function of the microbiome are now available. Postsurgical recurrence of IBD and treatment-naïve pediatric IBD are key populations to elucidate microbiome changes associated with the development of IBD. Our aims were to assess the community structure of the mucosa-associated microbiota of 'de novo' intestinal inflammation post-pouch surgery as well as treatment-naïve pediatric IBD and pediatric controls and to perform functional prediction of altered metabolic pathways.

AB - Background: Novel analytical frameworks to assess ecology and predictive function of the microbiome are now available. Postsurgical recurrence of IBD and treatment-naïve pediatric IBD are key populations to elucidate microbiome changes associated with the development of IBD. Our aims were to assess the community structure of the mucosa-associated microbiota of 'de novo' intestinal inflammation post-pouch surgery as well as treatment-naïve pediatric IBD and pediatric controls and to perform functional prediction of altered metabolic pathways.

KW - IBD

KW - Pouch Surgery

KW - Benzoate metabolism

U2 - 10.1093/ecco-jcc/jju027.833

DO - 10.1093/ecco-jcc/jju027.833

M3 - Abstract

VL - 9

SP - S439

JO - Journal of Crohn's and Colitis

JF - Journal of Crohn's and Colitis

SN - 1873-9946

IS - Suppl. 1

ER -