Assessment of community structure and predictive functional profiling of the mucosa-associated microbiome implicates alterations in benzoate metabolism in 'de novo' IBD after pouch-surgery and in treatment-naive pediatric IBD

J. Connors; R. Hansen; K. A. Dunn; M. G. Langille; R. K. Russell; A. R. Otley; B. MacIntyre; E. El-Omar; J. P. Bielawski; G. L. Hold; J. Van Limbergen

doi:10.1093/ecco-jcc/jju027.833

Assessment of community structure and predictive functional profiling of the mucosa-associated microbiome implicates alterations in benzoate metabolism in 'de novo' IBD after pouch-surgery and in treatment-naive pediatric IBD

J. Connors, R. Hansen, K. A. Dunn, M. G. Langille, R. K. Russell, A. R. Otley, B. MacIntyre, E. El-Omar, J. P. Bielawski, G. L. Hold, J. Van Limbergen

Applied Medicine

Research output: Contribution to journal › Abstract › peer-review

73 Citations (Scopus)

Abstract

Background: Novel analytical frameworks to assess ecology and predictive function of the microbiome are now available. Postsurgical recurrence of IBD and treatment-naïve pediatric IBD are key populations to elucidate microbiome changes associated with the development of IBD. Our aims were to assess the community structure of the mucosa-associated microbiota of 'de novo' intestinal inflammation post-pouch surgery as well as treatment-naïve pediatric IBD and pediatric controls and to perform functional prediction of altered metabolic pathways.

Original language	English
Pages (from-to)	S439
Number of pages	1
Journal	Journal of Crohn's and Colitis
Volume	9
Issue number	Suppl. 1
DOIs	https://doi.org/10.1093/ecco-jcc/jju027.833
Publication status	Published - Feb 2015

Keywords

IBD
Pouch Surgery
Benzoate metabolism

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Connors, J., Hansen, R., Dunn, K. A., Langille, M. G., Russell, R. K., Otley, A. R., MacIntyre, B., El-Omar, E., Bielawski, J. P., Hold, G. L., & Van Limbergen, J. (2015). Assessment of community structure and predictive functional profiling of the mucosa-associated microbiome implicates alterations in benzoate metabolism in 'de novo' IBD after pouch-surgery and in treatment-naive pediatric IBD. Journal of Crohn's and Colitis, 9(Suppl. 1), S439. https://doi.org/10.1093/ecco-jcc/jju027.833

Assessment of community structure and predictive functional profiling of the mucosa-associated microbiome implicates alterations in benzoate metabolism in 'de novo' IBD after pouch-surgery and in treatment-naive pediatric IBD. / Connors, J.; Hansen, R.; Dunn, K. A. et al.
In: Journal of Crohn's and Colitis, Vol. 9, No. Suppl. 1, 02.2015, p. S439.

Research output: Contribution to journal › Abstract › peer-review

Connors, J, Hansen, R, Dunn, KA, Langille, MG, Russell, RK, Otley, AR, MacIntyre, B, El-Omar, E, Bielawski, JP, Hold, GL & Van Limbergen, J 2015, 'Assessment of community structure and predictive functional profiling of the mucosa-associated microbiome implicates alterations in benzoate metabolism in 'de novo' IBD after pouch-surgery and in treatment-naive pediatric IBD', Journal of Crohn's and Colitis, vol. 9, no. Suppl. 1, pp. S439. https://doi.org/10.1093/ecco-jcc/jju027.833

Connors J, Hansen R, Dunn KA, Langille MG, Russell RK, Otley AR et al. Assessment of community structure and predictive functional profiling of the mucosa-associated microbiome implicates alterations in benzoate metabolism in 'de novo' IBD after pouch-surgery and in treatment-naive pediatric IBD. Journal of Crohn's and Colitis. 2015 Feb;9(Suppl. 1):S439. doi: 10.1093/ecco-jcc/jju027.833

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abstract = "Background: Novel analytical frameworks to assess ecology and predictive function of the microbiome are now available. Postsurgical recurrence of IBD and treatment-na{\"i}ve pediatric IBD are key populations to elucidate microbiome changes associated with the development of IBD. Our aims were to assess the community structure of the mucosa-associated microbiota of 'de novo' intestinal inflammation post-pouch surgery as well as treatment-na{\"i}ve pediatric IBD and pediatric controls and to perform functional prediction of altered metabolic pathways.",

keywords = "IBD, Pouch Surgery, Benzoate metabolism",

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AU - Hansen, R.

AU - Dunn, K. A.

AU - Langille, M. G.

AU - Russell, R. K.

AU - Otley, A. R.

AU - MacIntyre, B.

AU - El-Omar, E.

AU - Bielawski, J. P.

AU - Hold, G. L.

AU - Van Limbergen, J.

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N2 - Background: Novel analytical frameworks to assess ecology and predictive function of the microbiome are now available. Postsurgical recurrence of IBD and treatment-naïve pediatric IBD are key populations to elucidate microbiome changes associated with the development of IBD. Our aims were to assess the community structure of the mucosa-associated microbiota of 'de novo' intestinal inflammation post-pouch surgery as well as treatment-naïve pediatric IBD and pediatric controls and to perform functional prediction of altered metabolic pathways.

AB - Background: Novel analytical frameworks to assess ecology and predictive function of the microbiome are now available. Postsurgical recurrence of IBD and treatment-naïve pediatric IBD are key populations to elucidate microbiome changes associated with the development of IBD. Our aims were to assess the community structure of the mucosa-associated microbiota of 'de novo' intestinal inflammation post-pouch surgery as well as treatment-naïve pediatric IBD and pediatric controls and to perform functional prediction of altered metabolic pathways.

KW - IBD

KW - Pouch Surgery

KW - Benzoate metabolism

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DO - 10.1093/ecco-jcc/jju027.833

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