Assessment of community structure and predictive functional profiling of the mucosa-associated microbiome implicates alterations in benzoate metabolism in 'de novo' IBD after pouch-surgery and in treatment-naive pediatric IBD

J. Connors, R. Hansen, K. A. Dunn, M. G. Langille, R. K. Russell, A. R. Otley, B. MacIntyre, E. El-Omar, J. P. Bielawski, G. L. Hold, J. Van Limbergen

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Abstract

Background: Novel analytical frameworks to assess ecology and predictive function of the microbiome are now available. Postsurgical recurrence of IBD and treatment-naïve pediatric IBD are key populations to elucidate microbiome changes associated with the development of IBD. Our aims were to assess the community structure of the mucosa-associated microbiota of 'de novo' intestinal inflammation post-pouch surgery as well as treatment-naïve pediatric IBD and pediatric controls and to perform functional prediction of altered metabolic pathways.
Original languageEnglish
Pages (from-to)S439
Number of pages1
JournalJournal of Crohn's and Colitis
Volume9
Issue numberSuppl. 1
DOIs
Publication statusPublished - Feb 2015

Keywords

  • IBD
  • Pouch Surgery
  • Benzoate metabolism

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