Background: Novel analytical frameworks to assess ecology and predictive function of the microbiome are now available. Postsurgical recurrence of IBD and treatment-naïve pediatric IBD are key populations to elucidate microbiome changes associated with the development of IBD. Our aims were to assess the community structure of the mucosa-associated microbiota of 'de novo' intestinal inflammation post-pouch surgery as well as treatment-naïve pediatric IBD and pediatric controls and to perform functional prediction of altered metabolic pathways.
- Pouch Surgery
- Benzoate metabolism
Connors, J., Hansen, R., Dunn, K. A., Langille, M. G., Russell, R. K., Otley, A. R., MacIntyre, B., El-Omar, E., Bielawski, J. P., Hold, G. L., & Van Limbergen, J. (2015). Assessment of community structure and predictive functional profiling of the mucosa-associated microbiome implicates alterations in benzoate metabolism in 'de novo' IBD after pouch-surgery and in treatment-naive pediatric IBD. Journal of Crohn's and Colitis, 9(Suppl. 1), S439. https://doi.org/10.1093/ecco-jcc/jju027.833