Association between genotype at an exonic SNP in DISC1 and normal cognitive aging.

P. A. Thomson PA, S. E. Harris SE, J. M. Starr, Lawrence Jeffrey Whalley, D. J. Porteous, I. J. DEARY

    Research output: Contribution to journalArticle

    87 Citations (Scopus)

    Abstract

    DISC1 is expressed in the hippocampus and has been identified as a possible genetic risk factor for both schizophrenia and bipolar disorder. These psychiatric illnesses are associated with impaired learning and memory. This study investigates the association of variation in DISC1 with cognitive function on the same general mental ability test (Moray House Test) at age 11 and age 79, and cognitive change between ages 11 and 79, in 425 people from the Lothian Birth Cohort 1921 (LBC1921). Tests of memory, non-verbal reasoning and executive function were also administered at age 79. The effect of genotype at a non-synonymous single nucleotide polymorphism in exon 11, rs821616, was studied. There was no direct effect of DISC1 genotype on any cognitive measure. However, there was a significant DISC1 genotype by sex interaction on Moray House Test scores at age 79, both before and after adjustment for cognitive ability at age 11 (p=0.034 and 0.043, respectively). Women homozygous for the Cys allele had significantly lower cognitive ability scores than men at age 79, p=0.003. Variation in DISC1 may therefore affect cognitive aging especially in women. (C) 2005 Elsevier Ireland Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)41-45
    Number of pages4
    JournalNeuroscience Letters
    Volume389
    Issue number1
    DOIs
    Publication statusPublished - Nov 2005

    Keywords

    • cognitive aging
    • DISC1
    • hippocampus
    • association
    • verbal reasoning
    • BIPOLAR DISORDER
    • SCHIZOPHRENIA-1 DISC1
    • SUSCEPTIBILITY LOCUS
    • BRAIN-DEVELOPMENT
    • CHROMOSOME 1Q42
    • GENOME SCAN
    • FOLLOW-UP
    • TRANSLOCATION
    • LINKAGE
    • GENE

    Cite this

    Thomson PA, P. A., Harris SE, S. E., Starr, J. M., Whalley, L. J., Porteous, D. J., & DEARY, I. J. (2005). Association between genotype at an exonic SNP in DISC1 and normal cognitive aging. Neuroscience Letters, 389(1), 41-45. https://doi.org/10.1016/j.neulet.2005.07.004

    Association between genotype at an exonic SNP in DISC1 and normal cognitive aging. / Thomson PA, P. A.; Harris SE, S. E.; Starr, J. M.; Whalley, Lawrence Jeffrey; Porteous, D. J.; DEARY, I. J.

    In: Neuroscience Letters, Vol. 389, No. 1, 11.2005, p. 41-45.

    Research output: Contribution to journalArticle

    Thomson PA, PA, Harris SE, SE, Starr, JM, Whalley, LJ, Porteous, DJ & DEARY, IJ 2005, 'Association between genotype at an exonic SNP in DISC1 and normal cognitive aging.', Neuroscience Letters, vol. 389, no. 1, pp. 41-45. https://doi.org/10.1016/j.neulet.2005.07.004
    Thomson PA PA, Harris SE SE, Starr JM, Whalley LJ, Porteous DJ, DEARY IJ. Association between genotype at an exonic SNP in DISC1 and normal cognitive aging. Neuroscience Letters. 2005 Nov;389(1):41-45. https://doi.org/10.1016/j.neulet.2005.07.004
    Thomson PA, P. A. ; Harris SE, S. E. ; Starr, J. M. ; Whalley, Lawrence Jeffrey ; Porteous, D. J. ; DEARY, I. J. / Association between genotype at an exonic SNP in DISC1 and normal cognitive aging. In: Neuroscience Letters. 2005 ; Vol. 389, No. 1. pp. 41-45.
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