Association between raised inflammatory markers and cognitive decline in elderly people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study

Riccardo E Marioni, Mark W J Strachan, Rebecca M Reynolds, Gordon D O Lowe, Rory J Mitchell, F Gerry R Fowkes, Brian M Frier, Amanda Jane Lee, Isabella Butcher, Ann Rumley, Gordon D Murray, Ian J Deary, Jackie F Price

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

OBJECTIVE: To determine whether circulating levels of the inflammatory markers C-reactive protein (CRP), interleukin (IL)-6, and tumor necrosis factor (TNF)-alpha are associated with cognitive ability and estimated lifetime cognitive decline in an elderly population with type 2 diabetes. RESEARCH DESIGN AND METHODS: A cross-sectional study of 1,066 men and women aged 60-75 years with type 2 diabetes and living in Lothian, Scotland (the Edinburgh Type 2 Diabetes Study), was performed. Seven cognitive tests were used to measure abilities in memory, nonverbal reasoning, information processing speed, executive function, and mental flexibility. The results were used to derive a general intelligence factor (g). A vocabulary-based test was administered as an estimate of peak prior cognitive ability. Results on the cognitive tests were assessed for statistical association with inflammatory markers measured in a venous blood sample at the time of cognitive testing. RESULTS: Higher IL-6 and TNF-alpha levels were associated with poorer age- and sex-adjusted scores on the majority of the individual cognitive tests. They were also associated with g using standardized regression coefficients -0.074 to -0.173 (P <0.05). After adjusting for vocabulary, education level, cardiovascular dysfunction, duration of diabetes, and glycemic control, IL-6 remained associated with three of the cognitive tests and with g. CONCLUSIONS: In this representative population of people with type 2 diabetes, elevated circulating levels of inflammatory markers were associated with poorer cognitive ability. IL-6 levels were also associated with estimated lifetime cognitive decline.
Original languageEnglish
Pages (from-to)710-713
Number of pages4
JournalDiabetes
Volume59
Issue number3
Early online date3 Dec 2009
DOIs
Publication statusPublished - Mar 2010

Fingerprint

Aptitude
Type 2 Diabetes Mellitus
Interleukin-6
Tumor Necrosis Factor-alpha
Language Tests
Vocabulary
Executive Function
Scotland
Intelligence
Automatic Data Processing
C-Reactive Protein
Population
Research Design
Cross-Sectional Studies
Education
Cognitive Dysfunction

Keywords

  • Aged
  • Biological Markers
  • C-Reactive Protein
  • Cognition Disorders
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2
  • Female
  • Humans
  • Interleukin-6
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Risk Factors
  • Scotland
  • Tumor Necrosis Factor-alpha

Cite this

Marioni, R. E., Strachan, M. W. J., Reynolds, R. M., Lowe, G. D. O., Mitchell, R. J., Fowkes, F. G. R., ... Price, J. F. (2010). Association between raised inflammatory markers and cognitive decline in elderly people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study. Diabetes, 59(3), 710-713. https://doi.org/10.2337/db09-1163

Association between raised inflammatory markers and cognitive decline in elderly people with type 2 diabetes : the Edinburgh Type 2 Diabetes Study. / Marioni, Riccardo E; Strachan, Mark W J; Reynolds, Rebecca M; Lowe, Gordon D O; Mitchell, Rory J; Fowkes, F Gerry R; Frier, Brian M; Lee, Amanda Jane; Butcher, Isabella; Rumley, Ann; Murray, Gordon D; Deary, Ian J; Price, Jackie F.

In: Diabetes, Vol. 59, No. 3, 03.2010, p. 710-713.

Research output: Contribution to journalArticle

Marioni, RE, Strachan, MWJ, Reynolds, RM, Lowe, GDO, Mitchell, RJ, Fowkes, FGR, Frier, BM, Lee, AJ, Butcher, I, Rumley, A, Murray, GD, Deary, IJ & Price, JF 2010, 'Association between raised inflammatory markers and cognitive decline in elderly people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study', Diabetes, vol. 59, no. 3, pp. 710-713. https://doi.org/10.2337/db09-1163
Marioni, Riccardo E ; Strachan, Mark W J ; Reynolds, Rebecca M ; Lowe, Gordon D O ; Mitchell, Rory J ; Fowkes, F Gerry R ; Frier, Brian M ; Lee, Amanda Jane ; Butcher, Isabella ; Rumley, Ann ; Murray, Gordon D ; Deary, Ian J ; Price, Jackie F. / Association between raised inflammatory markers and cognitive decline in elderly people with type 2 diabetes : the Edinburgh Type 2 Diabetes Study. In: Diabetes. 2010 ; Vol. 59, No. 3. pp. 710-713.
@article{09015954888c46949cc23c07e45030dc,
title = "Association between raised inflammatory markers and cognitive decline in elderly people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study",
abstract = "OBJECTIVE: To determine whether circulating levels of the inflammatory markers C-reactive protein (CRP), interleukin (IL)-6, and tumor necrosis factor (TNF)-alpha are associated with cognitive ability and estimated lifetime cognitive decline in an elderly population with type 2 diabetes. RESEARCH DESIGN AND METHODS: A cross-sectional study of 1,066 men and women aged 60-75 years with type 2 diabetes and living in Lothian, Scotland (the Edinburgh Type 2 Diabetes Study), was performed. Seven cognitive tests were used to measure abilities in memory, nonverbal reasoning, information processing speed, executive function, and mental flexibility. The results were used to derive a general intelligence factor (g). A vocabulary-based test was administered as an estimate of peak prior cognitive ability. Results on the cognitive tests were assessed for statistical association with inflammatory markers measured in a venous blood sample at the time of cognitive testing. RESULTS: Higher IL-6 and TNF-alpha levels were associated with poorer age- and sex-adjusted scores on the majority of the individual cognitive tests. They were also associated with g using standardized regression coefficients -0.074 to -0.173 (P <0.05). After adjusting for vocabulary, education level, cardiovascular dysfunction, duration of diabetes, and glycemic control, IL-6 remained associated with three of the cognitive tests and with g. CONCLUSIONS: In this representative population of people with type 2 diabetes, elevated circulating levels of inflammatory markers were associated with poorer cognitive ability. IL-6 levels were also associated with estimated lifetime cognitive decline.",
keywords = "Aged, Biological Markers, C-Reactive Protein, Cognition Disorders, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Humans, Interleukin-6, Male, Middle Aged, Multivariate Analysis, Risk Factors, Scotland, Tumor Necrosis Factor-alpha",
author = "Marioni, {Riccardo E} and Strachan, {Mark W J} and Reynolds, {Rebecca M} and Lowe, {Gordon D O} and Mitchell, {Rory J} and Fowkes, {F Gerry R} and Frier, {Brian M} and Lee, {Amanda Jane} and Isabella Butcher and Ann Rumley and Murray, {Gordon D} and Deary, {Ian J} and Price, {Jackie F}",
year = "2010",
month = "3",
doi = "10.2337/db09-1163",
language = "English",
volume = "59",
pages = "710--713",
journal = "Diabetes",
issn = "0012-1797",
publisher = "AMER DIABETES ASSOC",
number = "3",

}

TY - JOUR

T1 - Association between raised inflammatory markers and cognitive decline in elderly people with type 2 diabetes

T2 - the Edinburgh Type 2 Diabetes Study

AU - Marioni, Riccardo E

AU - Strachan, Mark W J

AU - Reynolds, Rebecca M

AU - Lowe, Gordon D O

AU - Mitchell, Rory J

AU - Fowkes, F Gerry R

AU - Frier, Brian M

AU - Lee, Amanda Jane

AU - Butcher, Isabella

AU - Rumley, Ann

AU - Murray, Gordon D

AU - Deary, Ian J

AU - Price, Jackie F

PY - 2010/3

Y1 - 2010/3

N2 - OBJECTIVE: To determine whether circulating levels of the inflammatory markers C-reactive protein (CRP), interleukin (IL)-6, and tumor necrosis factor (TNF)-alpha are associated with cognitive ability and estimated lifetime cognitive decline in an elderly population with type 2 diabetes. RESEARCH DESIGN AND METHODS: A cross-sectional study of 1,066 men and women aged 60-75 years with type 2 diabetes and living in Lothian, Scotland (the Edinburgh Type 2 Diabetes Study), was performed. Seven cognitive tests were used to measure abilities in memory, nonverbal reasoning, information processing speed, executive function, and mental flexibility. The results were used to derive a general intelligence factor (g). A vocabulary-based test was administered as an estimate of peak prior cognitive ability. Results on the cognitive tests were assessed for statistical association with inflammatory markers measured in a venous blood sample at the time of cognitive testing. RESULTS: Higher IL-6 and TNF-alpha levels were associated with poorer age- and sex-adjusted scores on the majority of the individual cognitive tests. They were also associated with g using standardized regression coefficients -0.074 to -0.173 (P <0.05). After adjusting for vocabulary, education level, cardiovascular dysfunction, duration of diabetes, and glycemic control, IL-6 remained associated with three of the cognitive tests and with g. CONCLUSIONS: In this representative population of people with type 2 diabetes, elevated circulating levels of inflammatory markers were associated with poorer cognitive ability. IL-6 levels were also associated with estimated lifetime cognitive decline.

AB - OBJECTIVE: To determine whether circulating levels of the inflammatory markers C-reactive protein (CRP), interleukin (IL)-6, and tumor necrosis factor (TNF)-alpha are associated with cognitive ability and estimated lifetime cognitive decline in an elderly population with type 2 diabetes. RESEARCH DESIGN AND METHODS: A cross-sectional study of 1,066 men and women aged 60-75 years with type 2 diabetes and living in Lothian, Scotland (the Edinburgh Type 2 Diabetes Study), was performed. Seven cognitive tests were used to measure abilities in memory, nonverbal reasoning, information processing speed, executive function, and mental flexibility. The results were used to derive a general intelligence factor (g). A vocabulary-based test was administered as an estimate of peak prior cognitive ability. Results on the cognitive tests were assessed for statistical association with inflammatory markers measured in a venous blood sample at the time of cognitive testing. RESULTS: Higher IL-6 and TNF-alpha levels were associated with poorer age- and sex-adjusted scores on the majority of the individual cognitive tests. They were also associated with g using standardized regression coefficients -0.074 to -0.173 (P <0.05). After adjusting for vocabulary, education level, cardiovascular dysfunction, duration of diabetes, and glycemic control, IL-6 remained associated with three of the cognitive tests and with g. CONCLUSIONS: In this representative population of people with type 2 diabetes, elevated circulating levels of inflammatory markers were associated with poorer cognitive ability. IL-6 levels were also associated with estimated lifetime cognitive decline.

KW - Aged

KW - Biological Markers

KW - C-Reactive Protein

KW - Cognition Disorders

KW - Cross-Sectional Studies

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Humans

KW - Interleukin-6

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Risk Factors

KW - Scotland

KW - Tumor Necrosis Factor-alpha

U2 - 10.2337/db09-1163

DO - 10.2337/db09-1163

M3 - Article

C2 - 19959761

VL - 59

SP - 710

EP - 713

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 3

ER -