Association of chronic kidney disease with outcomes in acute stroke

Iong Man Tung, Raphae S. Barlas, Priya Vart, Joao H. Bettencourt-Silva, Allan B. Clark, Kittisak Sawanyawisuth, Kannikar Kongbunkiat, Narongrit Kasemsap, Somsak Tiamkao, Phyo K. Myint* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Previous studies have found an association between chronic kidney disease and poor outcomes in stroke patients. However, there is a paucity of literature evaluating this association by stroke type. We therefore aimed to explore the association between CKD and stroke outcomes according to type of stroke. The data consisting of 594,681 stroke patients were acquired from Universal Coverage Health Security Insurance Scheme Database in Thailand. Binary logistic regression was used to assess the relationship of CKD and outcomes, which were as follows; in-hospital mortality, long length of stay (>3 days), pneumonia, sepsis, respiratory failure and myocardial infarction. Results: after fully adjusting for covariates, CKD was associated with increased odds of in-hospital mortality in patients with ischemic (OR 1.32; 95% CI=1.27–1.38), haemorrhagic (OR 1.31; 95% CI=1.24–1.39), and other undetermined stroke type (OR 1.44; 95% CI=1.21–1.73). CKD was found to be associated with increased odds of pneumonia, sepsis, respiratory failure and myocardial infarction in ischaemic stroke. While CKD was found to be associated with increase odds of sepsis, respiratory failure, and myocardial infarction, decrease odds of pneumonia was observed in patients with haemorrhagic stroke. In other undetermined stroke type, CKD was found to only be associated with increase odds of sepsis and respiratory failure, while there is no signifcant association of CKD and increase or decrease odds with pneumonia and myocardial infarction. CKD was associated with poor outcomes in all stroke types. CKD should be considered as part of stroke prognosis as well as identifying at risk patient population for inhospital complications.
Original languageEnglish
Number of pages6
JournalActa Neurologica Belgica
Early online date13 Jul 2020
DOIs
Publication statusE-pub ahead of print - 13 Jul 2020

Keywords

  • chronic kidney disease
  • stroke
  • ischaemic
  • haemorrhagic
  • stroke type
  • complications
  • outcome
  • Stroke
  • Complications
  • Ischaemic
  • Haemorrhagic
  • Chronic kidney disease
  • Stroke type
  • Outcome
  • LONG-TERM
  • RISK-FACTORS
  • PROGNOSIS
  • DEATH
  • PULMONARY-EMBOLISM
  • CARDIOVASCULAR-DISEASE
  • INFECTION
  • CKD
  • ISCHEMIC-STROKE

Fingerprint Dive into the research topics of 'Association of chronic kidney disease with outcomes in acute stroke'. Together they form a unique fingerprint.

  • Cite this

    Tung, I. M., Barlas, R. S., Vart, P., Bettencourt-Silva, J. H., Clark, A. B., Sawanyawisuth, K., Kongbunkiat, K., Kasemsap, N., Tiamkao, S., & Myint, P. K. (2020). Association of chronic kidney disease with outcomes in acute stroke. Acta Neurologica Belgica. https://doi.org/10.1007/s13760-020-01416-0