Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia

Noa Carrera, Manuel Arrojo, Julio Sanjuán, Ramón Ramos-Ríos, Eduardo Paz, Jose J Suárez-Rama, Mario Páramo, Santiago Agra, Julio Brenlla, Silvia Martínez, Olga Rivero, David A Collier, Aarno Palotie, Sven Cichon, Markus M Nöthen, Marcella Rietschel, Dan Rujescu, Hreinn Stefansson, Stacy Steinberg, Engilbert Sigurdsson & 12 others David St Clair, Sarah Tosato, Thomas Werge, Kari Stefansson, Jose Carlos González, Joaquín Valero, Alfonso Gutiérrez-Zotes, Antonio Labad, Lourdes Martorell, Elisabet Vilella, Ángel Carracedo, Javier Costas

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Genome-wide association studies using several hundred thousand anonymous markers present limited statistical power. Alternatively, association studies restricted to common nonsynonymous single nucleotide polymorphisms (nsSNPs) have the advantage of strongly reducing the multiple testing problem, while increasing the probability of testing functional single nucleotide polymorphisms (SNPs).
Original languageEnglish
Pages (from-to)169-177
Number of pages9
JournalBiological Psychiatry
Volume71
Issue number2
Early online date10 Nov 2011
DOIs
Publication statusPublished - 15 Jan 2012

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Single Nucleotide Polymorphism
Schizophrenia
Genome-Wide Association Study

Keywords

  • adult
  • aged
  • aged, 80 and over
  • case-control studies
  • cation transport proteins
  • female
  • genetic association studies
  • genetic predisposition to disease
  • genotype
  • humans
  • male
  • middle aged
  • polymorphism, single nucleotide
  • schizophrenia
  • Spain

Cite this

Carrera, N., Arrojo, M., Sanjuán, J., Ramos-Ríos, R., Paz, E., Suárez-Rama, J. J., ... Costas, J. (2012). Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia. Biological Psychiatry, 71(2), 169-177. https://doi.org/10.1016/j.biopsych.2011.09.032

Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia. / Carrera, Noa; Arrojo, Manuel; Sanjuán, Julio; Ramos-Ríos, Ramón; Paz, Eduardo; Suárez-Rama, Jose J; Páramo, Mario; Agra, Santiago; Brenlla, Julio; Martínez, Silvia; Rivero, Olga; Collier, David A; Palotie, Aarno; Cichon, Sven; Nöthen, Markus M; Rietschel, Marcella; Rujescu, Dan; Stefansson, Hreinn; Steinberg, Stacy; Sigurdsson, Engilbert; St Clair, David; Tosato, Sarah; Werge, Thomas; Stefansson, Kari; González, Jose Carlos; Valero, Joaquín; Gutiérrez-Zotes, Alfonso; Labad, Antonio; Martorell, Lourdes; Vilella, Elisabet; Carracedo, Ángel; Costas, Javier.

In: Biological Psychiatry, Vol. 71, No. 2, 15.01.2012, p. 169-177.

Research output: Contribution to journalArticle

Carrera, N, Arrojo, M, Sanjuán, J, Ramos-Ríos, R, Paz, E, Suárez-Rama, JJ, Páramo, M, Agra, S, Brenlla, J, Martínez, S, Rivero, O, Collier, DA, Palotie, A, Cichon, S, Nöthen, MM, Rietschel, M, Rujescu, D, Stefansson, H, Steinberg, S, Sigurdsson, E, St Clair, D, Tosato, S, Werge, T, Stefansson, K, González, JC, Valero, J, Gutiérrez-Zotes, A, Labad, A, Martorell, L, Vilella, E, Carracedo, Á & Costas, J 2012, 'Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia' Biological Psychiatry, vol. 71, no. 2, pp. 169-177. https://doi.org/10.1016/j.biopsych.2011.09.032
Carrera N, Arrojo M, Sanjuán J, Ramos-Ríos R, Paz E, Suárez-Rama JJ et al. Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia. Biological Psychiatry. 2012 Jan 15;71(2):169-177. https://doi.org/10.1016/j.biopsych.2011.09.032
Carrera, Noa ; Arrojo, Manuel ; Sanjuán, Julio ; Ramos-Ríos, Ramón ; Paz, Eduardo ; Suárez-Rama, Jose J ; Páramo, Mario ; Agra, Santiago ; Brenlla, Julio ; Martínez, Silvia ; Rivero, Olga ; Collier, David A ; Palotie, Aarno ; Cichon, Sven ; Nöthen, Markus M ; Rietschel, Marcella ; Rujescu, Dan ; Stefansson, Hreinn ; Steinberg, Stacy ; Sigurdsson, Engilbert ; St Clair, David ; Tosato, Sarah ; Werge, Thomas ; Stefansson, Kari ; González, Jose Carlos ; Valero, Joaquín ; Gutiérrez-Zotes, Alfonso ; Labad, Antonio ; Martorell, Lourdes ; Vilella, Elisabet ; Carracedo, Ángel ; Costas, Javier. / Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia. In: Biological Psychiatry. 2012 ; Vol. 71, No. 2. pp. 169-177.
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