Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia

Noa Carrera, Manuel Arrojo, Julio Sanjuán, Ramón Ramos-Ríos, Eduardo Paz, Jose J Suárez-Rama, Mario Páramo, Santiago Agra, Julio Brenlla, Silvia Martínez, Olga Rivero, David A Collier, Aarno Palotie, Sven Cichon, Markus M Nöthen, Marcella Rietschel, Dan Rujescu, Hreinn Stefansson, Stacy Steinberg, Engilbert SigurdssonDavid St Clair, Sarah Tosato, Thomas Werge, Kari Stefansson, Jose Carlos González, Joaquín Valero, Alfonso Gutiérrez-Zotes, Antonio Labad, Lourdes Martorell, Elisabet Vilella, Ángel Carracedo, Javier Costas

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Abstract

Genome-wide association studies using several hundred thousand anonymous markers present limited statistical power. Alternatively, association studies restricted to common nonsynonymous single nucleotide polymorphisms (nsSNPs) have the advantage of strongly reducing the multiple testing problem, while increasing the probability of testing functional single nucleotide polymorphisms (SNPs).
Original languageEnglish
Pages (from-to)169-177
Number of pages9
JournalBiological Psychiatry
Volume71
Issue number2
Early online date10 Nov 2011
DOIs
Publication statusPublished - 15 Jan 2012

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Keywords

  • adult
  • aged
  • aged, 80 and over
  • case-control studies
  • cation transport proteins
  • female
  • genetic association studies
  • genetic predisposition to disease
  • genotype
  • humans
  • male
  • middle aged
  • polymorphism, single nucleotide
  • schizophrenia
  • Spain

Cite this

Carrera, N., Arrojo, M., Sanjuán, J., Ramos-Ríos, R., Paz, E., Suárez-Rama, J. J., ... Costas, J. (2012). Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia. Biological Psychiatry, 71(2), 169-177. https://doi.org/10.1016/j.biopsych.2011.09.032