Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia

Noa Carrera; Manuel Arrojo; Julio Sanjuán; Ramón Ramos-Ríos; Eduardo Paz; Jose J Suárez-Rama; Mario Páramo; Santiago Agra; Julio Brenlla; Silvia Martínez; Olga Rivero; David A Collier; Aarno Palotie; Sven Cichon; Markus M Nöthen; Marcella Rietschel; Dan Rujescu; Hreinn Stefansson; Stacy Steinberg; Engilbert Sigurdsson; David St Clair; Sarah Tosato; Thomas Werge; Kari Stefansson; Jose Carlos González; Joaquín Valero; Alfonso Gutiérrez-Zotes; Antonio Labad; Lourdes Martorell; Elisabet Vilella; Ángel Carracedo; Javier Costas

doi:10.1016/j.biopsych.2011.09.032

Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia

Noa Carrera, Manuel Arrojo, Julio Sanjuán, Ramón Ramos-Ríos, Eduardo Paz, Jose J Suárez-Rama, Mario Páramo, Santiago Agra, Julio Brenlla, Silvia Martínez, Olga Rivero, David A Collier, Aarno Palotie, Sven Cichon, Markus M Nöthen, Marcella Rietschel, Dan Rujescu, Hreinn Stefansson, Stacy Steinberg, Engilbert SigurdssonDavid St Clair, Sarah Tosato, Thomas Werge, Kari Stefansson, Jose Carlos González, Joaquín Valero, Alfonso Gutiérrez-Zotes, Antonio Labad, Lourdes Martorell, Elisabet Vilella, Ángel Carracedo, Javier Costas

Applied Medicine

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

Genome-wide association studies using several hundred thousand anonymous markers present limited statistical power. Alternatively, association studies restricted to common nonsynonymous single nucleotide polymorphisms (nsSNPs) have the advantage of strongly reducing the multiple testing problem, while increasing the probability of testing functional single nucleotide polymorphisms (SNPs).

Original language	English
Pages (from-to)	169-177
Number of pages	9
Journal	Biological Psychiatry
Volume	71
Issue number	2
Early online date	10 Nov 2011
DOIs	https://doi.org/10.1016/j.biopsych.2011.09.032
Publication status	Published - 15 Jan 2012

Keywords

adult
aged
aged, 80 and over
case-control studies
cation transport proteins
female
genetic association studies
genetic predisposition to disease
genotype
humans
male
middle aged
polymorphism, single nucleotide
schizophrenia
Spain

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Carrera, N., Arrojo, M., Sanjuán, J., Ramos-Ríos, R., Paz, E., Suárez-Rama, J. J., Páramo, M., Agra, S., Brenlla, J., Martínez, S., Rivero, O., Collier, D. A., Palotie, A., Cichon, S., Nöthen, M. M., Rietschel, M., Rujescu, D., Stefansson, H., Steinberg, S., ... Costas, J. (2012). Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia. Biological Psychiatry, 71(2), 169-177. https://doi.org/10.1016/j.biopsych.2011.09.032

Carrera, N, Arrojo, M, Sanjuán, J, Ramos-Ríos, R, Paz, E, Suárez-Rama, JJ, Páramo, M, Agra, S, Brenlla, J, Martínez, S, Rivero, O, Collier, DA, Palotie, A, Cichon, S, Nöthen, MM, Rietschel, M, Rujescu, D, Stefansson, H, Steinberg, S, Sigurdsson, E, St Clair, D, Tosato, S, Werge, T, Stefansson, K, González, JC, Valero, J, Gutiérrez-Zotes, A, Labad, A, Martorell, L, Vilella, E, Carracedo, Á & Costas, J 2012, 'Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia', Biological Psychiatry, vol. 71, no. 2, pp. 169-177. https://doi.org/10.1016/j.biopsych.2011.09.032

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title = "Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia",

abstract = "Genome-wide association studies using several hundred thousand anonymous markers present limited statistical power. Alternatively, association studies restricted to common nonsynonymous single nucleotide polymorphisms (nsSNPs) have the advantage of strongly reducing the multiple testing problem, while increasing the probability of testing functional single nucleotide polymorphisms (SNPs).",

keywords = "adult, aged, aged, 80 and over, case-control studies, cation transport proteins, female, genetic association studies, genetic predisposition to disease, genotype, humans, male, middle aged, polymorphism, single nucleotide, schizophrenia, Spain",

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AU - Paz, Eduardo

AU - Suárez-Rama, Jose J

AU - Páramo, Mario

AU - Agra, Santiago

AU - Brenlla, Julio

AU - Martínez, Silvia

AU - Rivero, Olga

AU - Collier, David A

AU - Palotie, Aarno

AU - Cichon, Sven

AU - Nöthen, Markus M

AU - Rietschel, Marcella

AU - Rujescu, Dan

AU - Stefansson, Hreinn

AU - Steinberg, Stacy

AU - Sigurdsson, Engilbert

AU - St Clair, David

AU - Tosato, Sarah

AU - Werge, Thomas

AU - Stefansson, Kari

AU - González, Jose Carlos

AU - Valero, Joaquín

AU - Gutiérrez-Zotes, Alfonso

AU - Labad, Antonio

AU - Martorell, Lourdes

AU - Vilella, Elisabet

AU - Carracedo, Ángel

AU - Costas, Javier

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KW - adult

KW - aged

KW - aged, 80 and over

KW - case-control studies

KW - cation transport proteins

KW - female

KW - genetic association studies

KW - genetic predisposition to disease

KW - genotype

KW - humans

KW - male

KW - middle aged

KW - polymorphism, single nucleotide

KW - schizophrenia

KW - Spain

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EP - 177

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 2

ER -

Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia

Abstract

Keywords

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