Abstract
Racemic perhexiline has been used (or is currently undergoing clinical trials) for the treatment of a variety of cardiovascular disorders. Increasing evidence suggests that the (–)-enantiomer should be used, as opposed to the racemic mixture. Here, we report the first asymmetric synthesis of both enantiomers of perhexiline in high enantiomeric excess and the assignment of their (–)-S/(+)-R absolute stereochemistry by X-ray crystallography.
Original language | English |
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Pages (from-to) | 73-78 |
Number of pages | 6 |
Journal | Synthesis |
Volume | 48 |
Issue number | 01 |
Early online date | 27 Oct 2015 |
DOIs | |
Publication status | Published - Jan 2016 |
Keywords
- perhexiline
- asymmetric analysis
- stereochemistry
- medicinal chemistry
- crystal structure