Autophagy in Alzheimer's disease

Paula I. Moreira, Renato X. Santos, Xiongwei Zhu, Hyoung-gon Lee, Mark A. Smith, Gemma Casadesus, George Perry*

*Corresponding author for this work

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Autophagy is a degradation pathway for the turnover of dysfunctional organelles or aggregated proteins in cells. Extensive literature exists supporting a causative role of mitochondrial dysfunction and amyloid-β protein in the pathogenesis of Alzheimer’s disease (AD). Furthermore, a link between mitochondrial dysfunction, amyloid-β levels and autophagy has been reported to occur in AD. However, it is not yet clear if autophagy plays a causative role, a protective role or is a consequence of the disease process itself. Understanding the exact role of autophagy in different stages of AD progression may help to design more effective therapeutic strategies. A central issue in developing therapies for neurodegenerative diseases involves understanding why and when responses to stress or injury can help prevent neuronal degeneration and death.
Original languageEnglish
Pages (from-to)1209-1218
Number of pages10
JournalExpert Review Neurotherapeutics
Volume10
Issue number7
DOIs
Publication statusPublished - Jul 2010

Keywords

  • Alzheimer’s disease
  • autophagy
  • death
  • neurodegeneration
  • protection
  • therapeutic target

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    Moreira, P. I., Santos, R. X., Zhu, X., Lee, H., Smith, M. A., Casadesus, G., & Perry, G. (2010). Autophagy in Alzheimer's disease. Expert Review Neurotherapeutics, 10(7), 1209-1218. https://doi.org/10.1586/ern.10.84