Azole-resistant aspergillosis

Adilia Warris*

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Azole-resistance in Aspergillus fumigatus is emerging and is becoming an increasing problem in the management of aspergillosis. Two types of development of resistance have been described; resistance acquired during azole treatment in an individual patient and through environmental exposure to fungicides. The main molecular mechanism of azole resistance in A. fumigatus is explained by mutations in the cyp51A-gene. The environmental route of resistance development is particularly worrying and may affect all patients whether azole exposed or naive, and whether suffering from acute or chronic aspergillosis. No management guidelines to assist clinicians confronted with azole-resistant aspergillosis are available and pre-clinical and clinical evidence supporting treatment choices is scarce. (C) 2015 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)S121-S125
Number of pages5
JournalJournal of Infection
Volume71
Issue numberSupplement 1
Early online date25 Apr 2015
DOIs
Publication statusPublished - Jun 2015

Keywords

  • A. fumigatus
  • aspergillosis
  • azoles
  • resistance
  • allergic bronchopulmonary aspergillosis
  • nervous-system aspergillosis
  • liposonal amphotericin-B
  • invasive aspergillosis
  • antifungal agents
  • 1st-line therapy
  • CYP51A gene
  • fumigatus
  • voriconazole
  • posaconazole

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