Bacterial Respiratory Pathogens in Children With Inherited Immune and Airway Disorders

Nasopharyngeal Carriage and Disease Risk

Lilly M. Verhagen, Maaike Luesink, Adilia Warris, Ronald de Groot, Peter W. M. Hermans

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Children with primary immunodeficiencies, sickle cell disease and cystic fibrosis are at risk to develop invasive bacterial infections caused by respiratory tract pathogens, in particular Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus. This review article evaluates the role of nasopharyngeal colonization by these pathogens in the high prevalence of respiratory and invasive infections in children with inherited disorders affecting the immune system or the respiratory tract. We conclude that respiratory and invasive diseases that occur in children with primary immunodeficiencies or sickle cell disease are probably a result of increased nasopharyngeal colonization rates compared with healthy children. However, when the inherited disorder is characterized by local airway abnormalities such as in cystic fibrosis, enhanced nasopharyngeal colonization does not seem to play a major role in invasive disease risk. As the evidence for the role of nasopharyngeal colonization in disease risk in these specific patient groups partly comes from experimental studies and animal models, longitudinal studies in children are needed. Detailed understanding of the effect of colonization on the development of respiratory and invasive infections in children with primary immunodeficiencies, sickle cell disease or cystic fibrosis provides a justification for the selective introduction of vaccination and prophylactic antibiotic treatment. Recommendations for the use of (preventive) therapeutic strategies in these patient groups taking into account disease-specific immunologic mechanisms underlying colonization and disease are described.

Original languageEnglish
Pages (from-to)399-404
Number of pages6
JournalPediatric Infectious Disease Journal
Volume32
Issue number4
DOIs
Publication statusPublished - Apr 2013

Fingerprint

Nasopharyngeal Diseases
Immune System Diseases
Sickle Cell Anemia
Cystic Fibrosis
Respiratory Tract Infections
Respiratory System
Haemophilus influenzae
Therapeutic Uses
Streptococcus pneumoniae
Bacterial Infections
Longitudinal Studies
Staphylococcus aureus
Immune System
Vaccination
Animal Models
Anti-Bacterial Agents

Keywords

  • respiratory tract pathogens
  • primary immunodeficiencies
  • sickle cell disease
  • cystic fibrosis
  • children

Cite this

Bacterial Respiratory Pathogens in Children With Inherited Immune and Airway Disorders : Nasopharyngeal Carriage and Disease Risk. / Verhagen, Lilly M.; Luesink, Maaike; Warris, Adilia; de Groot, Ronald; Hermans, Peter W. M.

In: Pediatric Infectious Disease Journal, Vol. 32, No. 4, 04.2013, p. 399-404.

Research output: Contribution to journalReview article

Verhagen, Lilly M. ; Luesink, Maaike ; Warris, Adilia ; de Groot, Ronald ; Hermans, Peter W. M. / Bacterial Respiratory Pathogens in Children With Inherited Immune and Airway Disorders : Nasopharyngeal Carriage and Disease Risk. In: Pediatric Infectious Disease Journal. 2013 ; Vol. 32, No. 4. pp. 399-404.
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