Bi-directional alterations of LTP after acute homocysteine exposure

Louisa A. Christie (Corresponding Author), Gernot Riedel* (Corresponding Author), Bettina Platt

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Homocysteine (HCY) is a known risk factor for neuronal diseases. We here report that HCY (10-1000 μM) interfered bi-directionally with long-term potentiation (LTP) in hippocampal slices, causing an impairment at concentrations <100 μM, and enhancement ≥500 μM. By comparison, NMDA unidirectionally reduced LTP, whereas l-cysteine led to facilitated LTP. Such HCY-induced alterations in neuronal communication may contribute to cognitive failure in dementia.

Original languageEnglish
Pages (from-to)559-563
Number of pages5
JournalBehavioural Brain Research
Volume205
Issue number2
DOIs
Publication statusPublished - 28 Dec 2009

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Keywords

  • Alzheimer's disease
  • CA1
  • Homocysteine
  • LTP
  • Rat
  • Slice

ASJC Scopus subject areas

  • Behavioral Neuroscience

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