Bi-directional alterations of LTP after acute homocysteine exposure

Louisa A. Christie; Gernot Riedel; Bettina Platt

doi:10.1016/j.bbr.2009.07.010

Bi-directional alterations of LTP after acute homocysteine exposure

Louisa A. Christie^* (Corresponding Author), Gernot Riedel^* (Corresponding Author), Bettina Platt

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Homocysteine (HCY) is a known risk factor for neuronal diseases. We here report that HCY (10-1000 μM) interfered bi-directionally with long-term potentiation (LTP) in hippocampal slices, causing an impairment at concentrations <100 μM, and enhancement ≥500 μM. By comparison, NMDA unidirectionally reduced LTP, whereas l-cysteine led to facilitated LTP. Such HCY-induced alterations in neuronal communication may contribute to cognitive failure in dementia.

Original language	English
Pages (from-to)	559-563
Number of pages	5
Journal	Behavioural Brain Research
Volume	205
Issue number	2
DOIs	https://doi.org/10.1016/j.bbr.2009.07.010
Publication status	Published - 28 Dec 2009

Bibliographical note

This work was supported by the Neuroscience Research Theme of the University of Aberdeen.

Keywords

Alzheimer's disease
CA1
Homocysteine
LTP
Rat
Slice

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title = "Bi-directional alterations of LTP after acute homocysteine exposure",

abstract = "Homocysteine (HCY) is a known risk factor for neuronal diseases. We here report that HCY (10-1000 μM) interfered bi-directionally with long-term potentiation (LTP) in hippocampal slices, causing an impairment at concentrations <100 μM, and enhancement ≥500 μM. By comparison, NMDA unidirectionally reduced LTP, whereas l-cysteine led to facilitated LTP. Such HCY-induced alterations in neuronal communication may contribute to cognitive failure in dementia.",

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AU - Christie, Louisa A.

AU - Riedel, Gernot

AU - Platt, Bettina

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PY - 2009/12/28

Y1 - 2009/12/28

N2 - Homocysteine (HCY) is a known risk factor for neuronal diseases. We here report that HCY (10-1000 μM) interfered bi-directionally with long-term potentiation (LTP) in hippocampal slices, causing an impairment at concentrations <100 μM, and enhancement ≥500 μM. By comparison, NMDA unidirectionally reduced LTP, whereas l-cysteine led to facilitated LTP. Such HCY-induced alterations in neuronal communication may contribute to cognitive failure in dementia.

AB - Homocysteine (HCY) is a known risk factor for neuronal diseases. We here report that HCY (10-1000 μM) interfered bi-directionally with long-term potentiation (LTP) in hippocampal slices, causing an impairment at concentrations <100 μM, and enhancement ≥500 μM. By comparison, NMDA unidirectionally reduced LTP, whereas l-cysteine led to facilitated LTP. Such HCY-induced alterations in neuronal communication may contribute to cognitive failure in dementia.

KW - Alzheimer's disease

KW - CA1

KW - Homocysteine

KW - LTP

KW - Rat

KW - Slice

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EP - 563

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IS - 2

ER -

Bi-directional alterations of LTP after acute homocysteine exposure

Abstract

Bibliographical note

Keywords

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