Biomass Utilization by Gut Microbiomes

Bryan A White, Raphael Lamed, Edward A Bayer, Harry J Flint

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Mammals rely entirely on symbiotic microorganisms within their digestive tract to gain energy from plant biomass that is resistant to mammalian digestive enzymes. Especially in herbivorous animals, specialized organs (the rumen, cecum, and colon) have evolved that allow highly efficient fermentation of ingested plant biomass by complex anaerobic microbial communities. We consider here the two most intensively studied, representative gut microbial communities involved in degradation of plant fiber: those of the rumen and the human large intestine. These communities are dominated by bacteria belonging to the Firmicutes and Bacteroidetes phyla. In Firmicutes, degradative capacity is largely restricted to the cell surface and involves elaborate cellulosome complexes in specialized cellulolytic species. By contrast, in the Bacteroidetes, utilization of soluble polysaccharides, encoded by gene clusters (PULs), entails outer membrane binding proteins, and degradation is largely periplasmic or intracellular. Biomass degradation involves complex interplay between these distinct groups of bacteria as well as (in the rumen) eukaryotic microorganisms. Expected final online publication date for the Annual Review of Microbiology Volume 68 is September 08, 2014. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.

Original languageEnglish
Pages (from-to)279-296
Number of pages18
JournalAnnual Review of Microbiology
Volume68
DOIs
Publication statusPublished - 16 Jun 2014

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Rumen
Biomass
Bacteroidetes
Cellulosomes
Bacteria
Animal Structures
Cecum
Large Intestine
Multigene Family
Microbiology
Proteolysis
Fermentation
Polysaccharides
Publications
Gastrointestinal Tract
Mammals
Carrier Proteins
Membrane Proteins
Colon
Enzymes

Cite this

Biomass Utilization by Gut Microbiomes. / White, Bryan A; Lamed, Raphael; Bayer, Edward A; Flint, Harry J.

In: Annual Review of Microbiology, Vol. 68, 16.06.2014, p. 279-296.

Research output: Contribution to journalArticle

White, Bryan A ; Lamed, Raphael ; Bayer, Edward A ; Flint, Harry J. / Biomass Utilization by Gut Microbiomes. In: Annual Review of Microbiology. 2014 ; Vol. 68. pp. 279-296.
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abstract = "Mammals rely entirely on symbiotic microorganisms within their digestive tract to gain energy from plant biomass that is resistant to mammalian digestive enzymes. Especially in herbivorous animals, specialized organs (the rumen, cecum, and colon) have evolved that allow highly efficient fermentation of ingested plant biomass by complex anaerobic microbial communities. We consider here the two most intensively studied, representative gut microbial communities involved in degradation of plant fiber: those of the rumen and the human large intestine. These communities are dominated by bacteria belonging to the Firmicutes and Bacteroidetes phyla. In Firmicutes, degradative capacity is largely restricted to the cell surface and involves elaborate cellulosome complexes in specialized cellulolytic species. By contrast, in the Bacteroidetes, utilization of soluble polysaccharides, encoded by gene clusters (PULs), entails outer membrane binding proteins, and degradation is largely periplasmic or intracellular. Biomass degradation involves complex interplay between these distinct groups of bacteria as well as (in the rumen) eukaryotic microorganisms. Expected final online publication date for the Annual Review of Microbiology Volume 68 is September 08, 2014. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.",
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