Abstract
The bone graft system comprises a solid inorganic component, which is bone graft material, and a hydrogel. The hydrogel contains >2ppm of silicon ions, calculated as parts by weight of Si per million of the aqueous component of the hydrogel. Preferably, the solid inorganic component comprises hydroxyapatite or a silicon-containing hydroxyapatite, and may be a silicon- containing hydroxyapatite having a Ca/P ratio in the range 2.05 to 2.55 and a Ca/(P + Si) molar ratio less than 1.66. Bone healing is promoted by delivery of silicon ion release from the hydrogel and by the solid inorganic component stimulating cell behaviour.
Original language | English |
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Patent number | WO2011GB00939 |
IPC | A61L27/46 |
Publication status | Published - 29 Dec 2011 |