TY - JOUR
T1 - Breast cancer risk and 6q22.33
T2 - combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2
AU - Kirchhoff, Tomas
AU - Gaudet, Mia M
AU - Antoniou, Antonis C
AU - McGuffog, Lesley
AU - Humphreys, Manjeet K
AU - Dunning, Alison M
AU - Bojesen, Stig E
AU - Nordestgaard, Børge G
AU - Flyger, Henrik
AU - Kang, Daehee
AU - Yoo, Keun-Young
AU - Noh, Dong-Young
AU - Ahn, Sei-Hyun
AU - Dork, Thilo
AU - Schürmann, Peter
AU - Karstens, Johann H
AU - Hillemanns, Peter
AU - Couch, Fergus J
AU - Olson, Janet
AU - Vachon, Celine
AU - Wang, Xianshu
AU - Cox, Angela
AU - Brock, Ian
AU - Elliott, Graeme
AU - Reed, Malcolm W R
AU - Burwinkel, Barbara
AU - Meindl, Alfons
AU - Brauch, Hiltrud
AU - Hamann, Ute
AU - Ko, Yon-Dschun
AU - GENICA Network
AU - Broeks, Annegien
AU - Schmidt, Marjanka K
AU - Van 't Veer, Laura J
AU - Braaf, Linde M
AU - Johnson, Nichola
AU - Fletcher, Olivia
AU - Gibson, Lorna
AU - Peto, Julian
AU - Turnbull, Clare
AU - Seal, Sheila
AU - Renwick, Anthony
AU - Rahman, Nazneen
AU - Wu, Pei-Ei
AU - Yu, Jyh-Cherng
AU - Hsiung, Chia-Ni
AU - Shen, Chen-Yang
AU - Southey, Melissa C
AU - Hopper, John L
AU - Hammet, Fleur
AU - kConFaB
AU - AOCS Study Group
AU - SWE-BRCA
AU - HEBON
AU - EMBRACE
AU - Miedzybrodzka, Zosia
PY - 2012/6/29
Y1 - 2012/6/29
N2 - Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC). In addition, we evaluated whether rs2180341 modifies breast cancer risk in 3,361 BRCA1 and 2,020 BRCA2 carriers from 11 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Based on the BCAC data from women of European ancestry, we found evidence for a weak association with breast cancer risk for rs2180341 (per-allele odds ratio (OR)¿=¿1.03, 95% CI 1.00-1.06, p¿=¿0.023). There was evidence for heterogeneity in the ORs among studies (I(2)¿=¿49.3%; p¿=¿
AB - Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC). In addition, we evaluated whether rs2180341 modifies breast cancer risk in 3,361 BRCA1 and 2,020 BRCA2 carriers from 11 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Based on the BCAC data from women of European ancestry, we found evidence for a weak association with breast cancer risk for rs2180341 (per-allele odds ratio (OR)¿=¿1.03, 95% CI 1.00-1.06, p¿=¿0.023). There was evidence for heterogeneity in the ORs among studies (I(2)¿=¿49.3%; p¿=¿
U2 - 10.1371/journal.pone.0035706
DO - 10.1371/journal.pone.0035706
M3 - Article
C2 - 22768030
SN - 1932-6203
VL - 7
JO - PloS ONE
JF - PloS ONE
IS - 6
M1 - e35706
ER -
