C-Type Lectin Receptors in Asthma

Sabelo Hadebe; Frank Brombacher; Gordon D. Brown

doi:10.3389/fimmu.2018.00733

C-Type Lectin Receptors in Asthma

Sabelo Hadebe, Frank Brombacher, Gordon D. Brown

Research output: Contribution to journal › Review article › peer-review

29 Citations (Scopus)

17 Downloads (Pure)

Abstract

Asthma is a heterogeneous disease that affects approximately 300 million people worldwide, largely in developed countries. The aetiology of the disease is poorly understood but is likely to involve specific innate and adaptive responses to inhaled microbial components that are found in allergens. Fungal derived allergens represent a major contributing factor in the initiation, persistence, exacerbation and severity of allergic asthma. C-type lectin like receptors such as Dectin-1, Dectin-2, DC-SIGN and Mannose receptor, recognise many fungal derived allergens and other structurally similar allergens derived from house dust mites (HDM). In some cases, the fungal derived allergens have been structurally and functionally identified alongside their respective receptors in both humans and mice. In this review, we discuss recent understanding on how selected fungal and HDM derived allergens as well as their known or unknown receptors shape allergic airway diseases.

Original language	English
Article number	733
Pages (from-to)	1-11
Number of pages	11
Journal	Frontiers in Immunology
Volume	9
DOIs	https://doi.org/10.3389/fimmu.2018.00733
Publication status	Published - 11 Apr 2018

Bibliographical note

This review is submitted as part of PhD thesis by SH. SH incepted, wrote the manuscript. G.D.B and F.B. edited the manuscript. SH PhD studentship was funded by CIDRI (Wellcome Trust initiative, South Africa) and the University of Aberdeen College studentship. GDB is funded by the Wellcome Trust and Medical Research Council Centre for Medical Mycology at the University of Aberdeen.

Keywords

C-type lectin receptors
Allergens
dectin-1
Fungi
sensitisation

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10.3389/fimmu.2018.00733Licence: CC BY

C-Type Lectin Receptors in Asthma
© 2018 Hadebe, Brombacher and Brown. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. https://creativecommons.org/licenses/by/4.0/
Final published version, 2.37 MBLicence: CC BY

Cite this

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abstract = "Asthma is a heterogeneous disease that affects approximately 300 million people worldwide, largely in developed countries. The aetiology of the disease is poorly understood but is likely to involve specific innate and adaptive responses to inhaled microbial components that are found in allergens. Fungal derived allergens represent a major contributing factor in the initiation, persistence, exacerbation and severity of allergic asthma. C-type lectin like receptors such as Dectin-1, Dectin-2, DC-SIGN and Mannose receptor, recognise many fungal derived allergens and other structurally similar allergens derived from house dust mites (HDM). In some cases, the fungal derived allergens have been structurally and functionally identified alongside their respective receptors in both humans and mice. In this review, we discuss recent understanding on how selected fungal and HDM derived allergens as well as their known or unknown receptors shape allergic airway diseases.",

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AB - Asthma is a heterogeneous disease that affects approximately 300 million people worldwide, largely in developed countries. The aetiology of the disease is poorly understood but is likely to involve specific innate and adaptive responses to inhaled microbial components that are found in allergens. Fungal derived allergens represent a major contributing factor in the initiation, persistence, exacerbation and severity of allergic asthma. C-type lectin like receptors such as Dectin-1, Dectin-2, DC-SIGN and Mannose receptor, recognise many fungal derived allergens and other structurally similar allergens derived from house dust mites (HDM). In some cases, the fungal derived allergens have been structurally and functionally identified alongside their respective receptors in both humans and mice. In this review, we discuss recent understanding on how selected fungal and HDM derived allergens as well as their known or unknown receptors shape allergic airway diseases.

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KW - Allergens

KW - dectin-1

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C-Type Lectin Receptors in Asthma

Abstract

Bibliographical note

Keywords

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