Candida albicans morphogenesis and host defence: discriminating invasion from colonization

Neil A. R. Gow, Frank L. van de Veerdonk, Alistair J. P. Brown, Mihai G. Netea

Research output: Contribution to journalArticle

434 Citations (Scopus)

Abstract

Candida albicans is a common fungal pathogen of humans that colonizes the skin and mucosal surfaces of most healthy individuals. Until recently, little was known about the mechanisms by which mucosal antifungal defences tolerate colonizing C. albicans but react strongly when hyphae of the same microorganism attempt to invade tissue. In this Review, we describe the properties of yeast cells and hyphae that are relevant to their interaction with the host, and the immunological mechanisms that differentially recognize colonizing versus invading C. albicans.
Original languageEnglish
Pages (from-to)112-122
Number of pages11
JournalNature Reviews Microbiology
Volume10
Issue number2
DOIs
Publication statusPublished - Feb 2012

Keywords

  • chronic mucocutaneous candidiasis
  • pattern-recognition receptors
  • C-type lectin
  • innate immune-system
  • T(H)17 cell-differentiation
  • macrophage mannose receptor
  • toll-like receptors
  • NLRP3 inflammasome
  • fungal-infections
  • epithelial-cells

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