Candida albicans morphogenesis and host defence: discriminating invasion from colonization

Neil A. R. Gow; Frank L. van de Veerdonk; Alistair J. P. Brown; Mihai G. Netea

doi:10.1038/nrmicro2711

Candida albicans morphogenesis and host defence: discriminating invasion from colonization

Neil A. R. Gow, Frank L. van de Veerdonk, Alistair J. P. Brown, Mihai G. Netea

Medical Sciences

Radboud University Nijmegen

Research output: Contribution to journal › Article › peer-review

637 Citations (Scopus)

Abstract

Candida albicans is a common fungal pathogen of humans that colonizes the skin and mucosal surfaces of most healthy individuals. Until recently, little was known about the mechanisms by which mucosal antifungal defences tolerate colonizing C. albicans but react strongly when hyphae of the same microorganism attempt to invade tissue. In this Review, we describe the properties of yeast cells and hyphae that are relevant to their interaction with the host, and the immunological mechanisms that differentially recognize colonizing versus invading C. albicans.

Original language	English
Pages (from-to)	112-122
Number of pages	11
Journal	Nature Reviews Microbiology
Volume	10
Issue number	2
DOIs	https://doi.org/10.1038/nrmicro2711
Publication status	Published - Feb 2012

Keywords

chronic mucocutaneous candidiasis
pattern-recognition receptors
C-type lectin
innate immune-system
T(H)17 cell-differentiation
macrophage mannose receptor
toll-like receptors
NLRP3 inflammasome
fungal-infections
epithelial-cells

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10.1038/nrmicro2711

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title = "Candida albicans morphogenesis and host defence: discriminating invasion from colonization",

abstract = "Candida albicans is a common fungal pathogen of humans that colonizes the skin and mucosal surfaces of most healthy individuals. Until recently, little was known about the mechanisms by which mucosal antifungal defences tolerate colonizing C. albicans but react strongly when hyphae of the same microorganism attempt to invade tissue. In this Review, we describe the properties of yeast cells and hyphae that are relevant to their interaction with the host, and the immunological mechanisms that differentially recognize colonizing versus invading C. albicans.",

keywords = "chronic mucocutaneous candidiasis, pattern-recognition receptors, C-type lectin, innate immune-system, T(H)17 cell-differentiation, macrophage mannose receptor, toll-like receptors, NLRP3 inflammasome, fungal-infections, epithelial-cells",

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AU - van de Veerdonk, Frank L.

AU - Brown, Alistair J. P.

AU - Netea, Mihai G.

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KW - pattern-recognition receptors

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KW - innate immune-system

KW - T(H)17 cell-differentiation

KW - macrophage mannose receptor

KW - toll-like receptors

KW - NLRP3 inflammasome

KW - fungal-infections

KW - epithelial-cells

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JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

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Candida albicans morphogenesis and host defence: discriminating invasion from colonization

Abstract

Keywords

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