Cannabinoid receptor mediated inhibition of excitatory synaptic transmission in the rat hippocampal slice is developmentally regulated

A Al-Hayani, S N Davies

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The cannabinoid (CB) receptor agonist WIN55,212-2 (500 nM) had no effect on the first of a pair of population spikes evoked in the CA1 region of hippocampal slices prepared from young adult (4-6 weeks old) rats, despite powerfully reducing paired-pulse depression. In contrast WIN55,212-2 caused a substantial depression of the single population spike (reduced to 43% control) and the field EPSP (reduced to 72% of control) recorded in slices prepared from neonatal (10-13 days old) rats. This effect was stereoselective and blocked by the CB1 receptor antagonist AM281 (500 nM). The results indicate that activation of CB1 receptors inhibits excitatory synaptic transmission in neonatal, but not adult rat hippocampus. This developmental regulation of CB1 receptor mediated control of excitatory transmission may help explain some, but not all, of the previous discrepancies in the Literature.

Original languageEnglish
Pages (from-to)663-665
Number of pages3
JournalBritish Journal of Pharmacology
Volume131
Publication statusPublished - 2000

Keywords

  • cannabinoid
  • CB1 receptor
  • WIN55,212-2
  • synaptic transmission
  • hippocampus
  • developmental regulation
  • paired-pulse depression
  • LONG-TERM POTENTIATION
  • INTERNEURONS
  • ANANDAMIDE
  • DEPRESSION
  • NEURONS

Cite this

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title = "Cannabinoid receptor mediated inhibition of excitatory synaptic transmission in the rat hippocampal slice is developmentally regulated",
abstract = "The cannabinoid (CB) receptor agonist WIN55,212-2 (500 nM) had no effect on the first of a pair of population spikes evoked in the CA1 region of hippocampal slices prepared from young adult (4-6 weeks old) rats, despite powerfully reducing paired-pulse depression. In contrast WIN55,212-2 caused a substantial depression of the single population spike (reduced to 43{\%} control) and the field EPSP (reduced to 72{\%} of control) recorded in slices prepared from neonatal (10-13 days old) rats. This effect was stereoselective and blocked by the CB1 receptor antagonist AM281 (500 nM). The results indicate that activation of CB1 receptors inhibits excitatory synaptic transmission in neonatal, but not adult rat hippocampus. This developmental regulation of CB1 receptor mediated control of excitatory transmission may help explain some, but not all, of the previous discrepancies in the Literature.",
keywords = "cannabinoid, CB1 receptor, WIN55,212-2, synaptic transmission, hippocampus, developmental regulation, paired-pulse depression, LONG-TERM POTENTIATION, INTERNEURONS, ANANDAMIDE, DEPRESSION, NEURONS",
author = "A Al-Hayani and Davies, {S N}",
year = "2000",
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journal = "British Journal of Pharmacology",
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TY - JOUR

T1 - Cannabinoid receptor mediated inhibition of excitatory synaptic transmission in the rat hippocampal slice is developmentally regulated

AU - Al-Hayani, A

AU - Davies, S N

PY - 2000

Y1 - 2000

N2 - The cannabinoid (CB) receptor agonist WIN55,212-2 (500 nM) had no effect on the first of a pair of population spikes evoked in the CA1 region of hippocampal slices prepared from young adult (4-6 weeks old) rats, despite powerfully reducing paired-pulse depression. In contrast WIN55,212-2 caused a substantial depression of the single population spike (reduced to 43% control) and the field EPSP (reduced to 72% of control) recorded in slices prepared from neonatal (10-13 days old) rats. This effect was stereoselective and blocked by the CB1 receptor antagonist AM281 (500 nM). The results indicate that activation of CB1 receptors inhibits excitatory synaptic transmission in neonatal, but not adult rat hippocampus. This developmental regulation of CB1 receptor mediated control of excitatory transmission may help explain some, but not all, of the previous discrepancies in the Literature.

AB - The cannabinoid (CB) receptor agonist WIN55,212-2 (500 nM) had no effect on the first of a pair of population spikes evoked in the CA1 region of hippocampal slices prepared from young adult (4-6 weeks old) rats, despite powerfully reducing paired-pulse depression. In contrast WIN55,212-2 caused a substantial depression of the single population spike (reduced to 43% control) and the field EPSP (reduced to 72% of control) recorded in slices prepared from neonatal (10-13 days old) rats. This effect was stereoselective and blocked by the CB1 receptor antagonist AM281 (500 nM). The results indicate that activation of CB1 receptors inhibits excitatory synaptic transmission in neonatal, but not adult rat hippocampus. This developmental regulation of CB1 receptor mediated control of excitatory transmission may help explain some, but not all, of the previous discrepancies in the Literature.

KW - cannabinoid

KW - CB1 receptor

KW - WIN55,212-2

KW - synaptic transmission

KW - hippocampus

KW - developmental regulation

KW - paired-pulse depression

KW - LONG-TERM POTENTIATION

KW - INTERNEURONS

KW - ANANDAMIDE

KW - DEPRESSION

KW - NEURONS

M3 - Article

VL - 131

SP - 663

EP - 665

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 0007-1188

ER -