Abstract
The effect of vitamin supplements on bone metabolism indices in patients with osteoporosis has received scant attention in the literature. Over a 2-week period, vitamin supplements of K and K+D were given to 20 post-menopausal osteoporotic women with previous Colles fractures. Osteoporosis was confirmed by bone mass measurements that demonstrated that broadband ultrasound attenuation (os calcis) was almost as discriminatory as dual energy X-ray absorptiometry (spine and hip) in Colles fracture patients compared with matched controls. Vitamin K corrected the carboxylation defect in osteocalcin and while less marked 4 weeks later, the improvement was still detectable. The result after K+D was similar. The level of carboxylation became the same as in premenopausal women. Total osteocalcin level (bound) osteocalcin. While there was vitamin K correctable undercarboxylation of osteocalcin, simultaneously there was no evidence of undercarboxylation of prothrombin.
Original language | English |
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Pages (from-to) | 15-20 |
Number of pages | 6 |
Journal | Bone |
Volume | 17 |
Issue number | 1 |
Publication status | Published - 1995 |
Keywords
- Absorptiometry, Photon
- Adult
- Aged
- Biological Markers
- Bone Density
- Colles' Fracture
- Cross-Over Studies
- Female
- Femur
- Humans
- Middle Aged
- Osteocalcin
- Osteoporosis, Postmenopausal
- Premenopause
- Protein Precursors
- Prothrombin
- ROC Curve
- Single-Blind Method
- Spinal Canal
- Vitamin D
- Vitamin K