Cardiac myoglobin deficit has evolved repeatedly in teleost fishes

Daniel J. MacQueen, Daniel Garcia de la serrana, Ian A. Johnston

Research output: Contribution to journalArticle

12 Citations (Scopus)
4 Downloads (Pure)

Abstract

Myoglobin (Mb) is the classic vertebrate oxygen-binding protein present in aerobic striated muscles. It functions principally in oxygen delivery and provides muscle with its characteristic red colour. Members of the Antarctic icefish family (Channichthyidae) are widely thought to be extraordinary for lacking cardiac Mb expression, a fact that has been attributed to their low metabolic rate and unusual evolutionary history. Here, we report that
cardiac Mb deficit, associated with pale heart colour, has evolved repeatedly during teleost evolution. This trait affects both gill- and air-breathing species from temperate to tropical habitats across a full range of salinities. Cardiac Mb deficit results from total pseudogenization in three-spined stickleback and is associated with a massive reduction in mRNA level in two species
that evidently retain functional Mb. The results suggest that near or complete absence of Mb-assisted oxygen delivery to heart muscle is a common facet of teleost biodiversity, even affecting lineages with notable oxygen demands.We suggest that Mb deficit may affect how different teleost species deal with increased tissue oxygen demands arising under climate change.
Original languageEnglish
Article number20140225
JournalBiology Letters
Volume10
Issue number6
DOIs
Publication statusPublished - 11 Jun 2014

Fingerprint

myoglobin
Myoglobin
Fishes
fish
Oxygen
oxygen
Color
heart
Smegmamorpha
muscles
striated muscle
Striated Muscle
color
Climate Change
Biodiversity
Gasterosteidae
Salinity
breathing
Ecosystem
Vertebrates

Keywords

  • myoglobin
  • oxygen supply
  • fish evolution
  • climate change

Cite this

MacQueen, D. J., Garcia de la serrana, D., & Johnston, I. A. (2014). Cardiac myoglobin deficit has evolved repeatedly in teleost fishes. Biology Letters, 10(6), [20140225]. https://doi.org/10.1098/rsbl.2014.0225

Cardiac myoglobin deficit has evolved repeatedly in teleost fishes. / MacQueen, Daniel J.; Garcia de la serrana, Daniel; Johnston, Ian A.

In: Biology Letters, Vol. 10, No. 6, 20140225, 11.06.2014.

Research output: Contribution to journalArticle

MacQueen, DJ, Garcia de la serrana, D & Johnston, IA 2014, 'Cardiac myoglobin deficit has evolved repeatedly in teleost fishes', Biology Letters, vol. 10, no. 6, 20140225. https://doi.org/10.1098/rsbl.2014.0225
MacQueen DJ, Garcia de la serrana D, Johnston IA. Cardiac myoglobin deficit has evolved repeatedly in teleost fishes. Biology Letters. 2014 Jun 11;10(6). 20140225. https://doi.org/10.1098/rsbl.2014.0225
MacQueen, Daniel J. ; Garcia de la serrana, Daniel ; Johnston, Ian A. / Cardiac myoglobin deficit has evolved repeatedly in teleost fishes. In: Biology Letters. 2014 ; Vol. 10, No. 6.
@article{6b757ff2552840abab19f2ddcc36bbcb,
title = "Cardiac myoglobin deficit has evolved repeatedly in teleost fishes",
abstract = "Myoglobin (Mb) is the classic vertebrate oxygen-binding protein present in aerobic striated muscles. It functions principally in oxygen delivery and provides muscle with its characteristic red colour. Members of the Antarctic icefish family (Channichthyidae) are widely thought to be extraordinary for lacking cardiac Mb expression, a fact that has been attributed to their low metabolic rate and unusual evolutionary history. Here, we report thatcardiac Mb deficit, associated with pale heart colour, has evolved repeatedly during teleost evolution. This trait affects both gill- and air-breathing species from temperate to tropical habitats across a full range of salinities. Cardiac Mb deficit results from total pseudogenization in three-spined stickleback and is associated with a massive reduction in mRNA level in two speciesthat evidently retain functional Mb. The results suggest that near or complete absence of Mb-assisted oxygen delivery to heart muscle is a common facet of teleost biodiversity, even affecting lineages with notable oxygen demands.We suggest that Mb deficit may affect how different teleost species deal with increased tissue oxygen demands arising under climate change.",
keywords = "myoglobin, oxygen supply, fish evolution, climate change",
author = "MacQueen, {Daniel J.} and {Garcia de la serrana}, Daniel and Johnston, {Ian A.}",
year = "2014",
month = "6",
day = "11",
doi = "10.1098/rsbl.2014.0225",
language = "English",
volume = "10",
journal = "Biology Letters",
issn = "1744-9561",
publisher = "ROYAL SOC CHEMISTRY",
number = "6",

}

TY - JOUR

T1 - Cardiac myoglobin deficit has evolved repeatedly in teleost fishes

AU - MacQueen, Daniel J.

AU - Garcia de la serrana, Daniel

AU - Johnston, Ian A.

PY - 2014/6/11

Y1 - 2014/6/11

N2 - Myoglobin (Mb) is the classic vertebrate oxygen-binding protein present in aerobic striated muscles. It functions principally in oxygen delivery and provides muscle with its characteristic red colour. Members of the Antarctic icefish family (Channichthyidae) are widely thought to be extraordinary for lacking cardiac Mb expression, a fact that has been attributed to their low metabolic rate and unusual evolutionary history. Here, we report thatcardiac Mb deficit, associated with pale heart colour, has evolved repeatedly during teleost evolution. This trait affects both gill- and air-breathing species from temperate to tropical habitats across a full range of salinities. Cardiac Mb deficit results from total pseudogenization in three-spined stickleback and is associated with a massive reduction in mRNA level in two speciesthat evidently retain functional Mb. The results suggest that near or complete absence of Mb-assisted oxygen delivery to heart muscle is a common facet of teleost biodiversity, even affecting lineages with notable oxygen demands.We suggest that Mb deficit may affect how different teleost species deal with increased tissue oxygen demands arising under climate change.

AB - Myoglobin (Mb) is the classic vertebrate oxygen-binding protein present in aerobic striated muscles. It functions principally in oxygen delivery and provides muscle with its characteristic red colour. Members of the Antarctic icefish family (Channichthyidae) are widely thought to be extraordinary for lacking cardiac Mb expression, a fact that has been attributed to their low metabolic rate and unusual evolutionary history. Here, we report thatcardiac Mb deficit, associated with pale heart colour, has evolved repeatedly during teleost evolution. This trait affects both gill- and air-breathing species from temperate to tropical habitats across a full range of salinities. Cardiac Mb deficit results from total pseudogenization in three-spined stickleback and is associated with a massive reduction in mRNA level in two speciesthat evidently retain functional Mb. The results suggest that near or complete absence of Mb-assisted oxygen delivery to heart muscle is a common facet of teleost biodiversity, even affecting lineages with notable oxygen demands.We suggest that Mb deficit may affect how different teleost species deal with increased tissue oxygen demands arising under climate change.

KW - myoglobin

KW - oxygen supply

KW - fish evolution

KW - climate change

U2 - 10.1098/rsbl.2014.0225

DO - 10.1098/rsbl.2014.0225

M3 - Article

VL - 10

JO - Biology Letters

JF - Biology Letters

SN - 1744-9561

IS - 6

M1 - 20140225

ER -