Cardiac myoglobin deficit has evolved repeatedly in teleost fishes

Daniel J. MacQueen, Daniel Garcia de la serrana, Ian A. Johnston

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Abstract

Myoglobin (Mb) is the classic vertebrate oxygen-binding protein present in aerobic striated muscles. It functions principally in oxygen delivery and provides muscle with its characteristic red colour. Members of the Antarctic icefish family (Channichthyidae) are widely thought to be extraordinary for lacking cardiac Mb expression, a fact that has been attributed to their low metabolic rate and unusual evolutionary history. Here, we report that
cardiac Mb deficit, associated with pale heart colour, has evolved repeatedly during teleost evolution. This trait affects both gill- and air-breathing species from temperate to tropical habitats across a full range of salinities. Cardiac Mb deficit results from total pseudogenization in three-spined stickleback and is associated with a massive reduction in mRNA level in two species
that evidently retain functional Mb. The results suggest that near or complete absence of Mb-assisted oxygen delivery to heart muscle is a common facet of teleost biodiversity, even affecting lineages with notable oxygen demands.We suggest that Mb deficit may affect how different teleost species deal with increased tissue oxygen demands arising under climate change.
Original languageEnglish
Article number20140225
JournalBiology Letters
Volume10
Issue number6
DOIs
Publication statusPublished - 11 Jun 2014

Keywords

  • myoglobin
  • oxygen supply
  • fish evolution
  • climate change

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    MacQueen, D. J., Garcia de la serrana, D., & Johnston, I. A. (2014). Cardiac myoglobin deficit has evolved repeatedly in teleost fishes. Biology Letters, 10(6), [20140225]. https://doi.org/10.1098/rsbl.2014.0225