Cell biology of Candida albicans-host interactions

Alessandra Da Silva Dantas, Kathy K LEE, Ingrida Raziunaite, Katja Schaefer, Jeanette Wagener, Bhawna Yadav, Neil Andrew Robert Gow

Research output: Contribution to journalArticle

44 Citations (Scopus)
6 Downloads (Pure)

Abstract

Candida albicans is a commensal coloniser of most people and a pathogen of the immunocompromised or patients in which barriers that prevent dissemination have been disrupted. Both the commensal and pathogenic states involve regulation and adaptation to the host microenvironment. The pathogenic potential can be downregulated to sustain commensalism or upregulated to damage host tissue and avoid and subvert immune surveillance. In either case it seems as though the cell biology of this fungus has evolved to enable the establishment of different types of relationships with the human host. Here we summarise latest advances in the analysis of mechanisms that enable C. albicans to occupy different body sites whilst avoiding being eliminated by the sentinel activities of the human immune system.
Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalCurrent Opinion in Microbiology
Volume34
Early online date28 Sep 2016
DOIs
Publication statusPublished - Dec 2016

Fingerprint

Candida albicans
Cell Biology
Symbiosis
Immunocompromised Host
Human Activities
Immune System
Fungi
Down-Regulation
cyhalothrin

Cite this

Cell biology of Candida albicans-host interactions. / Da Silva Dantas, Alessandra; LEE, Kathy K; Raziunaite, Ingrida; Schaefer, Katja; Wagener, Jeanette; Yadav, Bhawna; Gow, Neil Andrew Robert.

In: Current Opinion in Microbiology, Vol. 34, 12.2016, p. 111-118.

Research output: Contribution to journalArticle

Da Silva Dantas, A, LEE, KK, Raziunaite, I, Schaefer, K, Wagener, J, Yadav, B & Gow, NAR 2016, 'Cell biology of Candida albicans-host interactions', Current Opinion in Microbiology, vol. 34, pp. 111-118. https://doi.org/10.1016/j.mib.2016.08.006
Da Silva Dantas A, LEE KK, Raziunaite I, Schaefer K, Wagener J, Yadav B et al. Cell biology of Candida albicans-host interactions. Current Opinion in Microbiology. 2016 Dec;34:111-118. https://doi.org/10.1016/j.mib.2016.08.006
Da Silva Dantas, Alessandra ; LEE, Kathy K ; Raziunaite, Ingrida ; Schaefer, Katja ; Wagener, Jeanette ; Yadav, Bhawna ; Gow, Neil Andrew Robert. / Cell biology of Candida albicans-host interactions. In: Current Opinion in Microbiology. 2016 ; Vol. 34. pp. 111-118.
@article{3bf451f4cbe54e479846e14406169fd3,
title = "Cell biology of Candida albicans-host interactions",
abstract = "Candida albicans is a commensal coloniser of most people and a pathogen of the immunocompromised or patients in which barriers that prevent dissemination have been disrupted. Both the commensal and pathogenic states involve regulation and adaptation to the host microenvironment. The pathogenic potential can be downregulated to sustain commensalism or upregulated to damage host tissue and avoid and subvert immune surveillance. In either case it seems as though the cell biology of this fungus has evolved to enable the establishment of different types of relationships with the human host. Here we summarise latest advances in the analysis of mechanisms that enable C. albicans to occupy different body sites whilst avoiding being eliminated by the sentinel activities of the human immune system.",
author = "{Da Silva Dantas}, Alessandra and LEE, {Kathy K} and Ingrida Raziunaite and Katja Schaefer and Jeanette Wagener and Bhawna Yadav and Gow, {Neil Andrew Robert}",
note = "Acknowledgements The authors are supported by the Wellcome Trust via a Senior Investigator Award to NG, an ISST award and a Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology. The authors are also part of the MRC Centre for Medical Mycology at Aberdeen.",
year = "2016",
month = "12",
doi = "10.1016/j.mib.2016.08.006",
language = "English",
volume = "34",
pages = "111--118",
journal = "Current Opinion in Microbiology",
issn = "1369-5274",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Cell biology of Candida albicans-host interactions

AU - Da Silva Dantas, Alessandra

AU - LEE, Kathy K

AU - Raziunaite, Ingrida

AU - Schaefer, Katja

AU - Wagener, Jeanette

AU - Yadav, Bhawna

AU - Gow, Neil Andrew Robert

N1 - Acknowledgements The authors are supported by the Wellcome Trust via a Senior Investigator Award to NG, an ISST award and a Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology. The authors are also part of the MRC Centre for Medical Mycology at Aberdeen.

PY - 2016/12

Y1 - 2016/12

N2 - Candida albicans is a commensal coloniser of most people and a pathogen of the immunocompromised or patients in which barriers that prevent dissemination have been disrupted. Both the commensal and pathogenic states involve regulation and adaptation to the host microenvironment. The pathogenic potential can be downregulated to sustain commensalism or upregulated to damage host tissue and avoid and subvert immune surveillance. In either case it seems as though the cell biology of this fungus has evolved to enable the establishment of different types of relationships with the human host. Here we summarise latest advances in the analysis of mechanisms that enable C. albicans to occupy different body sites whilst avoiding being eliminated by the sentinel activities of the human immune system.

AB - Candida albicans is a commensal coloniser of most people and a pathogen of the immunocompromised or patients in which barriers that prevent dissemination have been disrupted. Both the commensal and pathogenic states involve regulation and adaptation to the host microenvironment. The pathogenic potential can be downregulated to sustain commensalism or upregulated to damage host tissue and avoid and subvert immune surveillance. In either case it seems as though the cell biology of this fungus has evolved to enable the establishment of different types of relationships with the human host. Here we summarise latest advances in the analysis of mechanisms that enable C. albicans to occupy different body sites whilst avoiding being eliminated by the sentinel activities of the human immune system.

U2 - 10.1016/j.mib.2016.08.006

DO - 10.1016/j.mib.2016.08.006

M3 - Article

VL - 34

SP - 111

EP - 118

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

SN - 1369-5274

ER -