Cell biology of Candida albicans-host interactions

Alessandra Da Silva Dantas, Kathy K LEE, Ingrida Raziunaite, Katja Schaefer, Jeanette Wagener, Bhawna Yadav, Neil Andrew Robert Gow

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58 Citations (Scopus)
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Abstract

Candida albicans is a commensal coloniser of most people and a pathogen of the immunocompromised or patients in which barriers that prevent dissemination have been disrupted. Both the commensal and pathogenic states involve regulation and adaptation to the host microenvironment. The pathogenic potential can be downregulated to sustain commensalism or upregulated to damage host tissue and avoid and subvert immune surveillance. In either case it seems as though the cell biology of this fungus has evolved to enable the establishment of different types of relationships with the human host. Here we summarise latest advances in the analysis of mechanisms that enable C. albicans to occupy different body sites whilst avoiding being eliminated by the sentinel activities of the human immune system.
Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalCurrent Opinion in Microbiology
Volume34
Early online date28 Sep 2016
DOIs
Publication statusPublished - Dec 2016

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    Da Silva Dantas, A., LEE, K. K., Raziunaite, I., Schaefer, K., Wagener, J., Yadav, B., & Gow, N. A. R. (2016). Cell biology of Candida albicans-host interactions. Current Opinion in Microbiology, 34, 111-118. https://doi.org/10.1016/j.mib.2016.08.006