Cell biology of Candida albicans-host interactions

Alessandra Da Silva Dantas; Kathy K LEE; Ingrida Raziunaite; Katja Schaefer; Jeanette Wagener; Bhawna Yadav; Neil Andrew Robert Gow

doi:10.1016/j.mib.2016.08.006

Cell biology of Candida albicans-host interactions

Alessandra Da Silva Dantas, Kathy K LEE, Ingrida Raziunaite, Katja Schaefer, Jeanette Wagener, Bhawna Yadav, Neil Andrew Robert Gow

Medical Sciences

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Abstract

Candida albicans is a commensal coloniser of most people and a pathogen of the immunocompromised or patients in which barriers that prevent dissemination have been disrupted. Both the commensal and pathogenic states involve regulation and adaptation to the host microenvironment. The pathogenic potential can be downregulated to sustain commensalism or upregulated to damage host tissue and avoid and subvert immune surveillance. In either case it seems as though the cell biology of this fungus has evolved to enable the establishment of different types of relationships with the human host. Here we summarise latest advances in the analysis of mechanisms that enable C. albicans to occupy different body sites whilst avoiding being eliminated by the sentinel activities of the human immune system.

Original language	English
Pages (from-to)	111-118
Number of pages	8
Journal	Current Opinion in Microbiology
Volume	34
Early online date	28 Sept 2016
DOIs	https://doi.org/10.1016/j.mib.2016.08.006
Publication status	Published - Dec 2016

Bibliographical note

Acknowledgements

The authors are supported by the Wellcome Trust via a Senior Investigator Award to NG, an ISST award and a Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology. The authors are also part of the MRC Centre for Medical Mycology at Aberdeen.

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10.1016/j.mib.2016.08.006Licence: CC BY-NC-ND

Cell biology of Candida albicans–host interactions
c 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Final published version, 1.14 MBLicence: CC BY-NC-ND

Cite this

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abstract = "Candida albicans is a commensal coloniser of most people and a pathogen of the immunocompromised or patients in which barriers that prevent dissemination have been disrupted. Both the commensal and pathogenic states involve regulation and adaptation to the host microenvironment. The pathogenic potential can be downregulated to sustain commensalism or upregulated to damage host tissue and avoid and subvert immune surveillance. In either case it seems as though the cell biology of this fungus has evolved to enable the establishment of different types of relationships with the human host. Here we summarise latest advances in the analysis of mechanisms that enable C. albicans to occupy different body sites whilst avoiding being eliminated by the sentinel activities of the human immune system.",

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AU - Da Silva Dantas, Alessandra

AU - LEE, Kathy K

AU - Raziunaite, Ingrida

AU - Schaefer, Katja

AU - Wagener, Jeanette

AU - Yadav, Bhawna

AU - Gow, Neil Andrew Robert

N1 - Acknowledgements The authors are supported by the Wellcome Trust via a Senior Investigator Award to NG, an ISST award and a Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology. The authors are also part of the MRC Centre for Medical Mycology at Aberdeen.

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AB - Candida albicans is a commensal coloniser of most people and a pathogen of the immunocompromised or patients in which barriers that prevent dissemination have been disrupted. Both the commensal and pathogenic states involve regulation and adaptation to the host microenvironment. The pathogenic potential can be downregulated to sustain commensalism or upregulated to damage host tissue and avoid and subvert immune surveillance. In either case it seems as though the cell biology of this fungus has evolved to enable the establishment of different types of relationships with the human host. Here we summarise latest advances in the analysis of mechanisms that enable C. albicans to occupy different body sites whilst avoiding being eliminated by the sentinel activities of the human immune system.

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DO - 10.1016/j.mib.2016.08.006

M3 - Article

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VL - 34

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JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

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Cell biology of Candida albicans-host interactions

Abstract

Bibliographical note

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