Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer

Scott Palmer; Karina Litvinova; Andrey Dunaev; Stewart Fleming; David McGloin; Ghulam Nabi

doi:10.1364/BOE.7.001193

Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer

Scott Palmer, Karina Litvinova, Andrey Dunaev, Stewart Fleming, David McGloin, Ghulam Nabi

Physics

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Muscle invasive urinary bladder cancer is one of the most lethal cancers and its detection at the time of transurethral resection remains limited and diagnostic methods are urgently needed. We have developed a muscle invasive transitional cell carcinoma (TCC) model of the bladder using porcine bladder scaffold and the human bladder cancer cell line 5637. The progression of implanted cancer cells to muscle invasion can be monitored by measuring changes in the spectrum of endogenous fluorophores such as reduced nicotinamide dinucleotide (NADH) and flavins. We believe this could act as a useful tool for the study of fluorescence dynamics of developing muscle invasive bladder cancer in patients.

Original language	English
Pages (from-to)	1193-1200
Number of pages	9
Journal	Biomedical Optics Express
Volume	7
Issue number	4
DOIs	https://doi.org/10.1364/BOE.7.001193
Publication status	Published - 7 Mar 2016

Bibliographical note

Publisher Copyright:
© 2016 Optical Society of America.

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AU - Palmer, Scott

AU - Litvinova, Karina

AU - Dunaev, Andrey

AU - Fleming, Stewart

AU - McGloin, David

AU - Nabi, Ghulam

PY - 2016/3/7

Y1 - 2016/3/7

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AB - Muscle invasive urinary bladder cancer is one of the most lethal cancers and its detection at the time of transurethral resection remains limited and diagnostic methods are urgently needed. We have developed a muscle invasive transitional cell carcinoma (TCC) model of the bladder using porcine bladder scaffold and the human bladder cancer cell line 5637. The progression of implanted cancer cells to muscle invasion can be monitored by measuring changes in the spectrum of endogenous fluorophores such as reduced nicotinamide dinucleotide (NADH) and flavins. We believe this could act as a useful tool for the study of fluorescence dynamics of developing muscle invasive bladder cancer in patients.

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Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer

Abstract

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