Characterisation of Drug Transporter Gene Expression in Colorectal Tissue and Cell Lines: Induction with Anti-retrovirals for Microbicide Optimization

Indrani Mukhopadhya, Susan Berry, Emad M El-Omar, John Thomson, Georgina L Hold, Karolin Hijazi

Research output: Contribution to journalAbstract

Abstract

Drug transporter expression in the colorectal epithelium is likely to play a role in the mucosal disposition of antiretrovirals (ARVs) in rectal microbicidal preparations and impact their efficacy in prevention of HIV-1 infection. However, there is
limited information on expression levels available. This study assessed expression of 84 drug transporter genes in human colorectal tissue and representative cell lines pre and post ARV exposure.
Original languageEnglish
Article numberP31.01
Pages (from-to)A201
JournalAIDS Research and Human Retroviruses
Volume30
Issue numberSuppl 1
DOIs
Publication statusPublished - Oct 2014

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