Characterisation of Drug Transporter Gene Expression in Colorectal Tissue and Cell Lines: Induction with Anti-retrovirals for Microbicide Optimization

Indrani Mukhopadhya; Susan Berry; Emad M El-Omar; John Thomson; Georgina L Hold; Karolin Hijazi

doi:10.1089/aid.2014.5433.abstract

Characterisation of Drug Transporter Gene Expression in Colorectal Tissue and Cell Lines: Induction with Anti-retrovirals for Microbicide Optimization

Indrani Mukhopadhya, Susan Berry, Emad M El-Omar, John Thomson, Georgina L Hold, Karolin Hijazi

Research output: Contribution to journal › Abstract › peer-review

Abstract

Drug transporter expression in the colorectal epithelium is likely to play a role in the mucosal disposition of antiretrovirals (ARVs) in rectal microbicidal preparations and impact their efficacy in prevention of HIV-1 infection. However, there is
limited information on expression levels available. This study assessed expression of 84 drug transporter genes in human colorectal tissue and representative cell lines pre and post ARV exposure.

Original language	English
Article number	P31.01
Pages (from-to)	A201
Journal	AIDS Research and Human Retroviruses
Volume	30
Issue number	Suppl 1
DOIs	https://doi.org/10.1089/aid.2014.5433.abstract
Publication status	Published - Oct 2014

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10.1089/aid.2014.5433.abstract

Karolin Hijazi
- School of Medicine, Medical Sciences & Nutrition, Dental Education - Clinical Chair
- Institute of Medical Sciences
Person: Clinical Academic

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Characterisation of Drug Transporter Gene Expression in Colorectal Tissue and Cell Lines : Induction with Anti-retrovirals for Microbicide Optimization. / Mukhopadhya, Indrani; Berry, Susan; El-Omar, Emad M et al.

In: AIDS Research and Human Retroviruses, Vol. 30 , No. Suppl 1, P31.01, 10.2014, p. A201.

Research output: Contribution to journal › Abstract › peer-review

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abstract = "Drug transporter expression in the colorectal epithelium is likely to play a role in the mucosal disposition of antiretrovirals (ARVs) in rectal microbicidal preparations and impact their efficacy in prevention of HIV-1 infection. However, there islimited information on expression levels available. This study assessed expression of 84 drug transporter genes in human colorectal tissue and representative cell lines pre and post ARV exposure.",

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AU - El-Omar, Emad M

AU - Thomson, John

AU - Hold, Georgina L

AU - Hijazi, Karolin

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AB - Drug transporter expression in the colorectal epithelium is likely to play a role in the mucosal disposition of antiretrovirals (ARVs) in rectal microbicidal preparations and impact their efficacy in prevention of HIV-1 infection. However, there islimited information on expression levels available. This study assessed expression of 84 drug transporter genes in human colorectal tissue and representative cell lines pre and post ARV exposure.

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Characterisation of Drug Transporter Gene Expression in Colorectal Tissue and Cell Lines: Induction with Anti-retrovirals for Microbicide Optimization

Abstract

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Karolin Hijazi

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