Characterising the impact of sex on severe asthma (SA) in the UK Severe Asthma Registry (UKSAR)

Lola  Loewenthal; John Busby; Ronald D  McDowell; Thomas  Brown; Hassan  Burhan; Rekha Chaudhuri; Paddy  Dennison; James W. Dodd; S Doe; Shoaib Faruqi; Robin  Gore; Elfatih Idris; David J Jackson; Mitesh  Patel; Thomas  Pantin; Ian D. Pavord; Paul E Pfeffer; David Price; Salman Siddiqui; Liam G Heaney; Andrew Menzies-Gow

doi:10.1183/13993003.congress-2022.308

Abstract

Introduction: Women are more likely to develop SA than their male counterparts. This analysis examines sex differences in disease, biological phenotype and treatment from UKSAR.Methods: Data for patients meeting the ERS/ATS SA criteria in UKSAR (n=3,679) was analysed by sex using univariate and multivariate logistic regression analyses.Results: SA patients were predominantly female (60.9%). Women were more likely to be obese (OR 1.67, 95% CI: 145, 1.93) and to have uncontrolled disease on asthma control questionnaire 6 (OR 1.14, 95% CI: 1.09, 1.18), more likely to have exacerbations (OR 1.13, 95% CI: 1.10, 1.17) and report asthma hospital admissions (OR 1.46 95% CI: 1.26, 1.70). Lung function was better in women, with percent predicted FEV1 3.9% higher than their male counterparts. Women had lower mean IgE (129 vs 208 IU/mL, p<0.001)) and mean FeNO (36 vs 46ppm, p<0.001) type-2 biomarkers but no significant difference in blood eosinophils or biologic therapy. Women were less likely to be on long-term OCS (OR 0.86, 95% CI: 0.75, 0.99). Results are displayed in figure 1.Conclusion: Significant differences were seen between the characteristics of men and women with SA. Women had worse asthma control, increased exacerbations and obesity despite higher FEV1 percent predicted, lower FeNO and Total IgE compared with their male counterparts. Understanding these disparities is important to deliver personalised SA treatment.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 308.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

Original language	English
Article number	308
Number of pages	2
Journal	European Respiratory Journal
Volume	60
Issue number	Suppl. 66
Early online date	4 Sept 2022
DOIs	https://doi.org/10.1183/13993003.congress-2022.308
Publication status	Published - 1 Dec 2022
Event	European Respiratory Society (ERS) International Congress. - FIRA Barcelona Gran Via Congress Centre, Barcelona, Spain Duration: 4 Sept 2022 → 6 Sept 2022 https://www.ersnet.org/congress-and-events/congress/

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1183/13993003.congress-2022.308Licence: Unspecified

Loewenthal_etal_ERS2022_Characterising_The_Impact_AAM
This is an author-submitted, peer-reviewed version of a manuscript that has been accepted for publication in the European Respiratory Journal, prior to copy-editing, formatting and typesetting. This version of the manuscript may not be duplicated or reproduced without prior permission from the European Respiratory Society. The publisher is not responsible or liable for any errors or omissions in this version of the manuscript or in any version derived from it by any other parties. The final, copy-edited, published article, which is the version of record, is available without a subscription 18 months after the date of issue publication. Final published version at: DOI: 10.1183/13993003.congress-2022.308
Accepted author manuscript, 107 KBLicence: Unspecified

http://erj.ersjournals.com/content/60/suppl_66/308.abstract

Cite this

Loewenthal, L., Busby, J., McDowell, R. D., Brown, T., Burhan, H., Chaudhuri, R., Dennison, P., Dodd, J. W., Doe, S., Faruqi, S., Gore, R., Idris, E., Jackson, D. J., Patel, M., Pantin, T., Pavord, I. D., Pfeffer, P. E., Price, D., Siddiqui, S., ... Menzies-Gow, A. (2022). Characterising the impact of sex on severe asthma (SA) in the UK Severe Asthma Registry (UKSAR). European Respiratory Journal, 60(Suppl. 66), Article 308. https://doi.org/10.1183/13993003.congress-2022.308

Loewenthal, L, Busby, J, McDowell, RD, Brown, T, Burhan, H, Chaudhuri, R, Dennison, P, Dodd, JW, Doe, S, Faruqi, S, Gore, R, Idris, E, Jackson, DJ, Patel, M, Pantin, T, Pavord, ID, Pfeffer, PE, Price, D, Siddiqui, S, Heaney, LG & Menzies-Gow, A 2022, 'Characterising the impact of sex on severe asthma (SA) in the UK Severe Asthma Registry (UKSAR)', European Respiratory Journal, vol. 60, no. Suppl. 66, 308. https://doi.org/10.1183/13993003.congress-2022.308

@article{e7e780dc31744f4aae08214273368fd6,

title = "Characterising the impact of sex on severe asthma (SA) in the UK Severe Asthma Registry (UKSAR)",

abstract = "Introduction: Women are more likely to develop SA than their male counterparts. This analysis examines sex differences in disease, biological phenotype and treatment from UKSAR.Methods: Data for patients meeting the ERS/ATS SA criteria in UKSAR (n=3,679) was analysed by sex using univariate and multivariate logistic regression analyses.Results: SA patients were predominantly female (60.9%). Women were more likely to be obese (OR 1.67, 95% CI: 145, 1.93) and to have uncontrolled disease on asthma control questionnaire 6 (OR 1.14, 95% CI: 1.09, 1.18), more likely to have exacerbations (OR 1.13, 95% CI: 1.10, 1.17) and report asthma hospital admissions (OR 1.46 95% CI: 1.26, 1.70). Lung function was better in women, with percent predicted FEV1 3.9% higher than their male counterparts. Women had lower mean IgE (129 vs 208 IU/mL, p<0.001)) and mean FeNO (36 vs 46ppm, p<0.001) type-2 biomarkers but no significant difference in blood eosinophils or biologic therapy. Women were less likely to be on long-term OCS (OR 0.86, 95% CI: 0.75, 0.99). Results are displayed in figure 1.Conclusion: Significant differences were seen between the characteristics of men and women with SA. Women had worse asthma control, increased exacerbations and obesity despite higher FEV1 percent predicted, lower FeNO and Total IgE compared with their male counterparts. Understanding these disparities is important to deliver personalised SA treatment.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 308.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).",

author = "Lola Loewenthal and John Busby and McDowell, {Ronald D} and Thomas Brown and Hassan Burhan and Rekha Chaudhuri and Paddy Dennison and Dodd, {James W.} and S Doe and Shoaib Faruqi and Robin Gore and Elfatih Idris and Jackson, {David J} and Mitesh Patel and Thomas Pantin and Pavord, {Ian D.} and Pfeffer, {Paul E} and David Price and Salman Siddiqui and Heaney, {Liam G} and Andrew Menzies-Gow",

year = "2022",

month = dec,

day = "1",

doi = "10.1183/13993003.congress-2022.308",

language = "English",

volume = "60",

journal = "European Respiratory Journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "Suppl. 66",

note = "European Respiratory Society (ERS) International Congress., ERS International Congress 2022 ; Conference date: 04-09-2022 Through 06-09-2022",

url = "https://www.ersnet.org/congress-and-events/congress/",

}

TY - JOUR

T1 - Characterising the impact of sex on severe asthma (SA) in the UK Severe Asthma Registry (UKSAR)

AU - Loewenthal, Lola

AU - Busby, John

AU - McDowell, Ronald D

AU - Brown, Thomas

AU - Burhan, Hassan

AU - Chaudhuri, Rekha

AU - Dennison, Paddy

AU - Dodd, James W.

AU - Doe, S

AU - Faruqi, Shoaib

AU - Gore, Robin

AU - Idris, Elfatih

AU - Jackson, David J

AU - Patel, Mitesh

AU - Pantin, Thomas

AU - Pavord, Ian D.

AU - Pfeffer, Paul E

AU - Price, David

AU - Siddiqui, Salman

AU - Heaney, Liam G

AU - Menzies-Gow, Andrew

PY - 2022/12/1

Y1 - 2022/12/1

N2 - Introduction: Women are more likely to develop SA than their male counterparts. This analysis examines sex differences in disease, biological phenotype and treatment from UKSAR.Methods: Data for patients meeting the ERS/ATS SA criteria in UKSAR (n=3,679) was analysed by sex using univariate and multivariate logistic regression analyses.Results: SA patients were predominantly female (60.9%). Women were more likely to be obese (OR 1.67, 95% CI: 145, 1.93) and to have uncontrolled disease on asthma control questionnaire 6 (OR 1.14, 95% CI: 1.09, 1.18), more likely to have exacerbations (OR 1.13, 95% CI: 1.10, 1.17) and report asthma hospital admissions (OR 1.46 95% CI: 1.26, 1.70). Lung function was better in women, with percent predicted FEV1 3.9% higher than their male counterparts. Women had lower mean IgE (129 vs 208 IU/mL, p<0.001)) and mean FeNO (36 vs 46ppm, p<0.001) type-2 biomarkers but no significant difference in blood eosinophils or biologic therapy. Women were less likely to be on long-term OCS (OR 0.86, 95% CI: 0.75, 0.99). Results are displayed in figure 1.Conclusion: Significant differences were seen between the characteristics of men and women with SA. Women had worse asthma control, increased exacerbations and obesity despite higher FEV1 percent predicted, lower FeNO and Total IgE compared with their male counterparts. Understanding these disparities is important to deliver personalised SA treatment.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 308.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

AB - Introduction: Women are more likely to develop SA than their male counterparts. This analysis examines sex differences in disease, biological phenotype and treatment from UKSAR.Methods: Data for patients meeting the ERS/ATS SA criteria in UKSAR (n=3,679) was analysed by sex using univariate and multivariate logistic regression analyses.Results: SA patients were predominantly female (60.9%). Women were more likely to be obese (OR 1.67, 95% CI: 145, 1.93) and to have uncontrolled disease on asthma control questionnaire 6 (OR 1.14, 95% CI: 1.09, 1.18), more likely to have exacerbations (OR 1.13, 95% CI: 1.10, 1.17) and report asthma hospital admissions (OR 1.46 95% CI: 1.26, 1.70). Lung function was better in women, with percent predicted FEV1 3.9% higher than their male counterparts. Women had lower mean IgE (129 vs 208 IU/mL, p<0.001)) and mean FeNO (36 vs 46ppm, p<0.001) type-2 biomarkers but no significant difference in blood eosinophils or biologic therapy. Women were less likely to be on long-term OCS (OR 0.86, 95% CI: 0.75, 0.99). Results are displayed in figure 1.Conclusion: Significant differences were seen between the characteristics of men and women with SA. Women had worse asthma control, increased exacerbations and obesity despite higher FEV1 percent predicted, lower FeNO and Total IgE compared with their male counterparts. Understanding these disparities is important to deliver personalised SA treatment.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 308.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

U2 - 10.1183/13993003.congress-2022.308

DO - 10.1183/13993003.congress-2022.308

M3 - Abstract

SN - 0903-1936

VL - 60

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - Suppl. 66

M1 - 308

T2 - European Respiratory Society (ERS) International Congress.

Y2 - 4 September 2022 through 6 September 2022

ER -

Characterising the impact of sex on severe asthma (SA) in the UK Severe Asthma Registry (UKSAR)

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this