Characterization of common genetic variants in cathepsin K and testing for association with bone mineral density in a large cohort of perimenopausal women from Scotland

F S  Giraudeau; R E  McGinnis; I C  Gray; E J  O'Brien; K E  Doncaster; N K  Spurr; S H  Ralston; D M  Reid; J  Wood

doi:10.1359/JBMR.0301205

Characterization of common genetic variants in cathepsin K and testing for association with bone mineral density in a large cohort of perimenopausal women from Scotland

F S Giraudeau, R E McGinnis, I C Gray, E J O'Brien, K E Doncaster, N K Spurr, S H Ralston, D M Reid, J Wood

Applied Medicine

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17 Citations (Scopus)

Abstract

BMD values in similar to3000 perimenopausal Scottish women were adjusted by regression to identify and account for nongenetic factors. Adjusted BMD values were not associated with simple tandem repeat (STR) markers or single nucleotide polymorphisms (SNPs) at the Cathepsin K (CTSK) locus. We present a thorough analysis of common CTSK polymorphisms and genetic relatedness among CTSK haplotypes.

Original language	English
Pages (from-to)	31-41
Number of pages	11
Journal	Journal of Bone and Mineral Research
Volume	19
DOIs	https://doi.org/10.1359/JBMR.0301205
Publication status	Published - 2004

Keywords

cathepsin K
bone mineral density
single nucleotide polymorphism
simple tandem repeat
haplotype
MOLECULAR-CLONING
IN-VIVO
INHIBITORS
POTENT
PYCNODYSOSTOSIS
OSTEOCLASTS
RESORPTION
EXPRESSION
CDNA
MICE

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10.1359/JBMR.0301205

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Giraudeau, F. S., McGinnis, R. E., Gray, I. C., O'Brien, E. J., Doncaster, K. E., Spurr, N. K., Ralston, S. H., Reid, D. M., & Wood, J. (2004). Characterization of common genetic variants in cathepsin K and testing for association with bone mineral density in a large cohort of perimenopausal women from Scotland. Journal of Bone and Mineral Research, 19, 31-41. https://doi.org/10.1359/JBMR.0301205

Giraudeau, FS, McGinnis, RE, Gray, IC, O'Brien, EJ, Doncaster, KE, Spurr, NK, Ralston, SH, Reid, DM & Wood, J 2004, 'Characterization of common genetic variants in cathepsin K and testing for association with bone mineral density in a large cohort of perimenopausal women from Scotland', Journal of Bone and Mineral Research, vol. 19, pp. 31-41. https://doi.org/10.1359/JBMR.0301205

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abstract = "BMD values in similar to3000 perimenopausal Scottish women were adjusted by regression to identify and account for nongenetic factors. Adjusted BMD values were not associated with simple tandem repeat (STR) markers or single nucleotide polymorphisms (SNPs) at the Cathepsin K (CTSK) locus. We present a thorough analysis of common CTSK polymorphisms and genetic relatedness among CTSK haplotypes.",

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author = "Giraudeau, {F S} and McGinnis, {R E} and Gray, {I C} and O'Brien, {E J} and Doncaster, {K E} and Spurr, {N K} and Ralston, {S H} and Reid, {D M} and J Wood",

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doi = "10.1359/JBMR.0301205",

language = "English",

volume = "19",

pages = "31--41",

journal = "Journal of Bone and Mineral Research",

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T1 - Characterization of common genetic variants in cathepsin K and testing for association with bone mineral density in a large cohort of perimenopausal women from Scotland

AU - Giraudeau, F S

AU - McGinnis, R E

AU - Gray, I C

AU - O'Brien, E J

AU - Doncaster, K E

AU - Spurr, N K

AU - Ralston, S H

AU - Reid, D M

AU - Wood, J

PY - 2004

Y1 - 2004

N2 - BMD values in similar to3000 perimenopausal Scottish women were adjusted by regression to identify and account for nongenetic factors. Adjusted BMD values were not associated with simple tandem repeat (STR) markers or single nucleotide polymorphisms (SNPs) at the Cathepsin K (CTSK) locus. We present a thorough analysis of common CTSK polymorphisms and genetic relatedness among CTSK haplotypes.

AB - BMD values in similar to3000 perimenopausal Scottish women were adjusted by regression to identify and account for nongenetic factors. Adjusted BMD values were not associated with simple tandem repeat (STR) markers or single nucleotide polymorphisms (SNPs) at the Cathepsin K (CTSK) locus. We present a thorough analysis of common CTSK polymorphisms and genetic relatedness among CTSK haplotypes.

KW - cathepsin K

KW - bone mineral density

KW - single nucleotide polymorphism

KW - simple tandem repeat

KW - haplotype

KW - MOLECULAR-CLONING

KW - IN-VIVO

KW - INHIBITORS

KW - POTENT

KW - PYCNODYSOSTOSIS

KW - OSTEOCLASTS

KW - RESORPTION

KW - EXPRESSION

KW - CDNA

KW - MICE

U2 - 10.1359/JBMR.0301205

DO - 10.1359/JBMR.0301205

M3 - Article

SN - 1523-4681

VL - 19

SP - 31

EP - 41

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

ER -

Characterization of common genetic variants in cathepsin K and testing for association with bone mineral density in a large cohort of perimenopausal women from Scotland

Abstract

Keywords

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