Characterization of common genetic variants in cathepsin K and testing for association with bone mineral density in a large cohort of perimenopausal women from Scotland

F S Giraudeau, R E McGinnis, I C Gray, E J O'Brien, K E Doncaster, N K Spurr, S H Ralston, D M Reid, J Wood

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

BMD values in similar to3000 perimenopausal Scottish women were adjusted by regression to identify and account for nongenetic factors. Adjusted BMD values were not associated with simple tandem repeat (STR) markers or single nucleotide polymorphisms (SNPs) at the Cathepsin K (CTSK) locus. We present a thorough analysis of common CTSK polymorphisms and genetic relatedness among CTSK haplotypes.

Original languageEnglish
Pages (from-to)31-41
Number of pages11
JournalJournal of Bone and Mineral Research
Volume19
DOIs
Publication statusPublished - 2004

Keywords

  • cathepsin K
  • bone mineral density
  • single nucleotide polymorphism
  • simple tandem repeat
  • haplotype
  • MOLECULAR-CLONING
  • IN-VIVO
  • INHIBITORS
  • POTENT
  • PYCNODYSOSTOSIS
  • OSTEOCLASTS
  • RESORPTION
  • EXPRESSION
  • CDNA
  • MICE

Cite this

Characterization of common genetic variants in cathepsin K and testing for association with bone mineral density in a large cohort of perimenopausal women from Scotland. / Giraudeau, F S ; McGinnis, R E ; Gray, I C ; O'Brien, E J ; Doncaster, K E ; Spurr, N K ; Ralston, S H ; Reid, D M ; Wood, J .

In: Journal of Bone and Mineral Research, Vol. 19, 2004, p. 31-41.

Research output: Contribution to journalArticle

Giraudeau, F S ; McGinnis, R E ; Gray, I C ; O'Brien, E J ; Doncaster, K E ; Spurr, N K ; Ralston, S H ; Reid, D M ; Wood, J . / Characterization of common genetic variants in cathepsin K and testing for association with bone mineral density in a large cohort of perimenopausal women from Scotland. In: Journal of Bone and Mineral Research. 2004 ; Vol. 19. pp. 31-41.
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AU - Giraudeau, F S

AU - McGinnis, R E

AU - Gray, I C

AU - O'Brien, E J

AU - Doncaster, K E

AU - Spurr, N K

AU - Ralston, S H

AU - Reid, D M

AU - Wood, J

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KW - POTENT

KW - PYCNODYSOSTOSIS

KW - OSTEOCLASTS

KW - RESORPTION

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JO - Journal of Bone and Mineral Research

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