Characterization of the Myocardial Inflammatory Response in Acute Stress-Induced (Takotsubo) Cardiomyopathy

Heather M. Wilson, Lesley Cheyne, Paul A J Brown, Keith Kerr, Andrew Hannah, Janaki Srinivasan, Natallia Duniak, Graham Horgan, Dana K Dawson

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Abstract

Takotsubo cardiomyopathy is an acute stress-induced heart failure syndrome for which the exact pathogenic mechanisms are unclear, and consequently, no specific treatment exists. In an experimental model of stress-induced takotsubo-like cardiomyopathy, the authors describe the temporal course of a chronic inflammatory response post-induction, with an initial early influx of neutrophils into myocardial tissue followed by macrophages that are typical of a proinflammatory M1 phenotype, and a nonsignificant increase in systemic inflammatory cytokines. Post-mortem myocardium from the more complex clinical takotsubo patients share features of the study’s experimental model. These findings suggest modulators of inflammation could be a potential therapeutic option.

Original languageEnglish
Pages (from-to)766-778
Number of pages13
JournalJACC: Basic to Translational Science
Volume3
Issue number6
Early online date31 Dec 2018
DOIs
Publication statusPublished - Dec 2018

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Takotsubo Cardiomyopathy
Theoretical Models
Myocardium
Neutrophils
Heart Failure
Macrophages
Cytokines
Inflammation
Phenotype
Therapeutics

Cite this

Characterization of the Myocardial Inflammatory Response in Acute Stress-Induced (Takotsubo) Cardiomyopathy. / Wilson, Heather M.; Cheyne, Lesley; Brown, Paul A J; Kerr, Keith; Hannah, Andrew; Srinivasan, Janaki; Duniak, Natallia ; Horgan, Graham; Dawson, Dana K.

In: JACC: Basic to Translational Science, Vol. 3, No. 6, 12.2018, p. 766-778.

Research output: Contribution to journalArticle

Wilson, Heather M. ; Cheyne, Lesley ; Brown, Paul A J ; Kerr, Keith ; Hannah, Andrew ; Srinivasan, Janaki ; Duniak, Natallia ; Horgan, Graham ; Dawson, Dana K. / Characterization of the Myocardial Inflammatory Response in Acute Stress-Induced (Takotsubo) Cardiomyopathy. In: JACC: Basic to Translational Science. 2018 ; Vol. 3, No. 6. pp. 766-778.
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AU - Srinivasan, Janaki

AU - Duniak, Natallia

AU - Horgan, Graham

AU - Dawson, Dana K

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