Characterization of the Myocardial Inflammatory Response in Acute Stress-Induced (Takotsubo) Cardiomyopathy

Heather M. Wilson, Lesley Cheyne, Paul A J Brown, Keith Kerr, Andrew Hannah, Janaki Srinivasan, Natallia Duniak, Graham Horgan, Dana K Dawson

Research output: Contribution to journalArticle

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Abstract

Takotsubo cardiomyopathy is an acute stress-induced heart failure syndrome for which the exact pathogenic mechanisms are unclear, and consequently, no specific treatment exists. In an experimental model of stress-induced takotsubo-like cardiomyopathy, the authors describe the temporal course of a chronic inflammatory response post-induction, with an initial early influx of neutrophils into myocardial tissue followed by macrophages that are typical of a proinflammatory M1 phenotype, and a nonsignificant increase in systemic inflammatory cytokines. Post-mortem myocardium from the more complex clinical takotsubo patients share features of the study’s experimental model. These findings suggest modulators of inflammation could be a potential therapeutic option.

Original languageEnglish
Pages (from-to)766-778
Number of pages13
JournalJACC: Basic to Translational Science
Volume3
Issue number6
Early online date31 Dec 2018
DOIs
Publication statusPublished - Dec 2018

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