Chemical genetics: receptor-ligand pairs for rapid manipulation of neuronal activity

Peer Wulff; Benjamin R Arenkiel

doi:10.1016/j.conb.2011.10.008

Chemical genetics: receptor-ligand pairs for rapid manipulation of neuronal activity

Peer Wulff, Benjamin R Arenkiel

Medical Sciences

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

10 Downloads (Pure)

Abstract

Toward the functional dissection of neuronal circuits, a number of new genetic tools have been developed that enable rapid and reversible manipulation of genetically defined neuronal subtypes in intact mammalian brain circuits. Alongside the breakthrough technology of optogenetics, receptor-ligand pairs provide complementary approaches to modulate neuronal activity using chemical genetics.

Original language	English
Pages (from-to)	54-60
Number of pages	7
Journal	Current Opinion in Neurobiology
Volume	22
Issue number	1
Early online date	24 Nov 2011
DOIs	https://doi.org/10.1016/j.conb.2011.10.008
Publication status	Published - Feb 2012

Bibliographical note

PMID: 22119143 [PubMed - indexed for MEDLINE] PMCID: PMC3294416 Free PMC Article

Access to Document

10.1016/j.conb.2011.10.008

1-s2.0-S0959438811001747-main
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/3.0/
Final published version, 576 KB

Cite this

@article{a6c579f1667445ffab3a850ca8427ea7,

title = "Chemical genetics: receptor-ligand pairs for rapid manipulation of neuronal activity",

abstract = "Toward the functional dissection of neuronal circuits, a number of new genetic tools have been developed that enable rapid and reversible manipulation of genetically defined neuronal subtypes in intact mammalian brain circuits. Alongside the breakthrough technology of optogenetics, receptor-ligand pairs provide complementary approaches to modulate neuronal activity using chemical genetics.",

author = "Peer Wulff and Arenkiel, {Benjamin R}",

note = "PMID: 22119143 [PubMed - indexed for MEDLINE] PMCID: PMC3294416 Free PMC Article",

year = "2012",

month = feb,

doi = "10.1016/j.conb.2011.10.008",

language = "English",

volume = "22",

pages = "54--60",

journal = "Current Opinion in Neurobiology",

publisher = "Elsevier Limited",

number = "1",

}

TY - JOUR

T1 - Chemical genetics

T2 - receptor-ligand pairs for rapid manipulation of neuronal activity

AU - Wulff, Peer

AU - Arenkiel, Benjamin R

N1 - PMID: 22119143 [PubMed - indexed for MEDLINE] PMCID: PMC3294416 Free PMC Article

PY - 2012/2

Y1 - 2012/2

N2 - Toward the functional dissection of neuronal circuits, a number of new genetic tools have been developed that enable rapid and reversible manipulation of genetically defined neuronal subtypes in intact mammalian brain circuits. Alongside the breakthrough technology of optogenetics, receptor-ligand pairs provide complementary approaches to modulate neuronal activity using chemical genetics.

AB - Toward the functional dissection of neuronal circuits, a number of new genetic tools have been developed that enable rapid and reversible manipulation of genetically defined neuronal subtypes in intact mammalian brain circuits. Alongside the breakthrough technology of optogenetics, receptor-ligand pairs provide complementary approaches to modulate neuronal activity using chemical genetics.

U2 - 10.1016/j.conb.2011.10.008

DO - 10.1016/j.conb.2011.10.008

M3 - Article

C2 - 22119143

VL - 22

SP - 54

EP - 60

JO - Current Opinion in Neurobiology

JF - Current Opinion in Neurobiology

IS - 1

ER -

Chemical genetics: receptor-ligand pairs for rapid manipulation of neuronal activity

Abstract

Bibliographical note

Access to Document

Fingerprint

Cite this