Chitin synthesis and fungal pathogenesis

Megan D Lenardon, Carol A Munro, Neil AR Gow

Research output: Contribution to journalLiterature review

173 Citations (Scopus)
6 Downloads (Pure)

Abstract

Chitin is an essential part of the carbohydrate skeleton of the fungal cell wall and is a molecule that is not represented in humans and other vertebrates. Complex regulatory mechanisms enable chitin to be positioned at specific sites throughout the cell cycle to maintain the overall strength of the wall and enable rapid, life-saving modifications to be made under cell wall stress conditions. Chitin has also recently emerged as a significant player in the activation and attenuation of immune responses to fungi and other chitin-containing parasites. This review summarises latest advances in the analysis of chitin synthesis regulation in the context of fungal pathogenesis.

Original languageEnglish
Pages (from-to)416-423
Number of pages8
JournalCurrent Opinion in Microbiology
Volume13
Issue number4
Early online date8 Jun 2010
DOIs
Publication statusPublished - Aug 2010

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