Chitin synthesis and fungal pathogenesis

Megan D Lenardon; Carol A Munro; Neil AR Gow

doi:10.1016/j.mib.2010.05.002

Chitin synthesis and fungal pathogenesis

Megan D Lenardon, Carol A Munro, Neil AR Gow

Medical Sciences

Research output: Contribution to journal › Literature review › peer-review

317 Citations (Scopus)

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Abstract

Chitin is an essential part of the carbohydrate skeleton of the fungal cell wall and is a molecule that is not represented in humans and other vertebrates. Complex regulatory mechanisms enable chitin to be positioned at specific sites throughout the cell cycle to maintain the overall strength of the wall and enable rapid, life-saving modifications to be made under cell wall stress conditions. Chitin has also recently emerged as a significant player in the activation and attenuation of immune responses to fungi and other chitin-containing parasites. This review summarises latest advances in the analysis of chitin synthesis regulation in the context of fungal pathogenesis.

Original language	English
Pages (from-to)	416-423
Number of pages	8
Journal	Current Opinion in Microbiology
Volume	13
Issue number	4
Early online date	8 Jun 2010
DOIs	https://doi.org/10.1016/j.mib.2010.05.002
Publication status	Published - Aug 2010

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Lenardon et al Curr Op Micro 2010 Chitin reviewFinal published version, 685 KB

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abstract = "Chitin is an essential part of the carbohydrate skeleton of the fungal cell wall and is a molecule that is not represented in humans and other vertebrates. Complex regulatory mechanisms enable chitin to be positioned at specific sites throughout the cell cycle to maintain the overall strength of the wall and enable rapid, life-saving modifications to be made under cell wall stress conditions. Chitin has also recently emerged as a significant player in the activation and attenuation of immune responses to fungi and other chitin-containing parasites. This review summarises latest advances in the analysis of chitin synthesis regulation in the context of fungal pathogenesis. ",

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AU - Munro, Carol A

AU - Gow, Neil AR

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AB - Chitin is an essential part of the carbohydrate skeleton of the fungal cell wall and is a molecule that is not represented in humans and other vertebrates. Complex regulatory mechanisms enable chitin to be positioned at specific sites throughout the cell cycle to maintain the overall strength of the wall and enable rapid, life-saving modifications to be made under cell wall stress conditions. Chitin has also recently emerged as a significant player in the activation and attenuation of immune responses to fungi and other chitin-containing parasites. This review summarises latest advances in the analysis of chitin synthesis regulation in the context of fungal pathogenesis.

U2 - 10.1016/j.mib.2010.05.002

DO - 10.1016/j.mib.2010.05.002

M3 - Literature review

SN - 1879-0364

VL - 13

SP - 416

EP - 423

JO - Current Opinion in Microbiology

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Chitin synthesis and fungal pathogenesis

Abstract

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