Clenbuterol, A BETA-Adrenoceptor Agonist, Increases Relative Muscle Strength in Orthopedic Patients

C A Maltin, Margaret Inkster Delday, J S Watson, Steven Darryll Heys, I M Nevison, I K Ritchie, P H Gibson

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

1. The sympathomimetic agent clenbuterol has a muscle-specific anabolic effect in normal and wasted muscles from animals. This trial was designed to examine the effect of the drug on the recovery of muscle strength and area after open medial meniscectomy.

2. A double-blind, completely randomized, placebo-controlled study was carried out on 20 healthy male patients. Muscle strength and cross-sectional area were determined before and after surgery. Patients were treated with drug or placebo for 4 weeks postoperatively and there was a 2 week washout period.

3. The results suggest that, in the operated leg, clenbuterol treatment is associated with a more rapid rehabilitation of strength in knee extensor muscles; in the unoperated leg, knee extensor strength increased above the initial values after 6 weeks (P=0.01). However, in terms of absolute strength the differences were not significant between the two groups.

4. It is concluded that the data lend support to the proposition that clenbuterol has therapeutic potential in the treatment of muscle-wasting conditions.

Original languageEnglish
Pages (from-to)651-654
Number of pages4
JournalClinical Science
Volume84
Issue number6
Publication statusPublished - Jun 1993

Keywords

  • BETA-AGONISTS
  • ATROPHY
  • MENISCECTOMY
  • MUSCLE STRENGTH
  • REHABILITATION
  • BETA-2-RECEPTOR AGONIST
  • SKELETAL-MUSCLE
  • GROWTH
  • AREA
  • RATS
  • beta-agonists
  • atrophy
  • meniscectomy
  • muscle strength
  • rehabilitation

Cite this

Maltin, C. A., Delday, M. I., Watson, J. S., Heys, S. D., Nevison, I. M., Ritchie, I. K., & Gibson, P. H. (1993). Clenbuterol, A BETA-Adrenoceptor Agonist, Increases Relative Muscle Strength in Orthopedic Patients. Clinical Science, 84(6), 651-654.

Clenbuterol, A BETA-Adrenoceptor Agonist, Increases Relative Muscle Strength in Orthopedic Patients. / Maltin, C A ; Delday, Margaret Inkster; Watson, J S ; Heys, Steven Darryll; Nevison, I M ; Ritchie, I K ; Gibson, P H .

In: Clinical Science, Vol. 84, No. 6, 06.1993, p. 651-654.

Research output: Contribution to journalArticle

Maltin, CA, Delday, MI, Watson, JS, Heys, SD, Nevison, IM, Ritchie, IK & Gibson, PH 1993, 'Clenbuterol, A BETA-Adrenoceptor Agonist, Increases Relative Muscle Strength in Orthopedic Patients', Clinical Science, vol. 84, no. 6, pp. 651-654.
Maltin CA, Delday MI, Watson JS, Heys SD, Nevison IM, Ritchie IK et al. Clenbuterol, A BETA-Adrenoceptor Agonist, Increases Relative Muscle Strength in Orthopedic Patients. Clinical Science. 1993 Jun;84(6):651-654.
Maltin, C A ; Delday, Margaret Inkster ; Watson, J S ; Heys, Steven Darryll ; Nevison, I M ; Ritchie, I K ; Gibson, P H . / Clenbuterol, A BETA-Adrenoceptor Agonist, Increases Relative Muscle Strength in Orthopedic Patients. In: Clinical Science. 1993 ; Vol. 84, No. 6. pp. 651-654.
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N2 - 1. The sympathomimetic agent clenbuterol has a muscle-specific anabolic effect in normal and wasted muscles from animals. This trial was designed to examine the effect of the drug on the recovery of muscle strength and area after open medial meniscectomy.2. A double-blind, completely randomized, placebo-controlled study was carried out on 20 healthy male patients. Muscle strength and cross-sectional area were determined before and after surgery. Patients were treated with drug or placebo for 4 weeks postoperatively and there was a 2 week washout period.3. The results suggest that, in the operated leg, clenbuterol treatment is associated with a more rapid rehabilitation of strength in knee extensor muscles; in the unoperated leg, knee extensor strength increased above the initial values after 6 weeks (P=0.01). However, in terms of absolute strength the differences were not significant between the two groups.4. It is concluded that the data lend support to the proposition that clenbuterol has therapeutic potential in the treatment of muscle-wasting conditions.

AB - 1. The sympathomimetic agent clenbuterol has a muscle-specific anabolic effect in normal and wasted muscles from animals. This trial was designed to examine the effect of the drug on the recovery of muscle strength and area after open medial meniscectomy.2. A double-blind, completely randomized, placebo-controlled study was carried out on 20 healthy male patients. Muscle strength and cross-sectional area were determined before and after surgery. Patients were treated with drug or placebo for 4 weeks postoperatively and there was a 2 week washout period.3. The results suggest that, in the operated leg, clenbuterol treatment is associated with a more rapid rehabilitation of strength in knee extensor muscles; in the unoperated leg, knee extensor strength increased above the initial values after 6 weeks (P=0.01). However, in terms of absolute strength the differences were not significant between the two groups.4. It is concluded that the data lend support to the proposition that clenbuterol has therapeutic potential in the treatment of muscle-wasting conditions.

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