Abstract
The pathology of vulvovaginal candidiasis (VVC) caused by Candida albicans is associated with a nonprotective inflammatory response and is frequently treated with clotrimazole. We investigated the mechanisms by which clotrimazole resolves VVC. Low levels of clotrimazole, which do not block fungal growth, inhibit expression of a "danger response" transcription factor, c-Fos, block production of proinflammatory cytokines, and inhibit neutrophil infiltration to the site of infection.
Original language | English |
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Pages (from-to) | 5178-5180 |
Number of pages | 3 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 57 |
Issue number | 10 |
Early online date | 29 Jul 2013 |
DOIs | |
Publication status | Published - Oct 2013 |
Keywords
- Candida albicans
- Candidiasis, Vulvovaginal
- Cell Line
- Clotrimazole
- Female
- Humans
- Neutrophil Infiltration