Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection

Duncan Wilson, Betty Hebecker, David L Moyes, Pedro Miramón, Nadja Jablonowski, Stephanie Wisgott, Stefanie Allert, Julian R Naglik, Bernhard Hube

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6 Citations (Scopus)

Abstract

The pathology of vulvovaginal candidiasis (VVC) caused by Candida albicans is associated with a nonprotective inflammatory response and is frequently treated with clotrimazole. We investigated the mechanisms by which clotrimazole resolves VVC. Low levels of clotrimazole, which do not block fungal growth, inhibit expression of a "danger response" transcription factor, c-Fos, block production of proinflammatory cytokines, and inhibit neutrophil infiltration to the site of infection.
Original languageEnglish
Pages (from-to)5178-5180
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number10
Early online date29 Jul 2013
DOIs
Publication statusPublished - Oct 2013

Keywords

  • Candida albicans
  • Candidiasis, Vulvovaginal
  • Cell Line
  • Clotrimazole
  • Female
  • Humans
  • Neutrophil Infiltration

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    Wilson, D., Hebecker, B., Moyes, D. L., Miramón, P., Jablonowski, N., Wisgott, S., Allert, S., Naglik, J. R., & Hube, B. (2013). Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection. Antimicrobial Agents and Chemotherapy, 57(10), 5178-5180. https://doi.org/10.1128/AAC.01244-13