Cofactor NAD(P)H regeneration inspired by heterogeneous pathways

Xiaodong Wang (Corresponding Author), Tony Saba, Humphrey H.P. Yiu, Russell F. Howe, James A Anderson, Jiafu Shi (Corresponding Author)

Research output: Contribution to journalArticle

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Abstract

Biocatalysis can empower chemical, pharmaceutical, and energy industries, where the use of enzymes facilitates low-energy, sustainable methods of producing high-value chemicals and pharmaceuticals that are otherwise impossibly troublesome or costly to obtain. One of the largest classes of enzymes (oxidoreductases, ∼25% of the total) capable of promoting bioreduction reactions is vital for the global pharmaceutical and chemical market because of their intrinsic enantioselectivity and specificity. Enzymatic reduction depends on a coenzyme or cofactor as a hydride source, namely nicotinamide adenine dinucleotide (NADH) or its phosphorylated form (NADPH). Given the high cost, stoichiometric usage, and physical instability of NAD(P)H, a suitable method for NAD(P)H regeneration is essential for practical application. This review summarizes the existing methods for NAD(P)H regeneration, including enzymatic, chemical, homogeneous catalytic, electrochemical, photocatalytic, and heterogeneous catalytic routes. Particular focus is given to recent progress in developing heterogeneous systems with potential significance in terms of process simplicity, cleanliness, and energy and/or cost savings.
Original languageEnglish
Pages (from-to)621-654
Number of pages34
JournalChem
Volume2
Issue number5
DOIs
Publication statusPublished - 11 May 2017

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NAD
Pharmaceutical Preparations
Enantioselectivity
Coenzymes
Enzymes
NADP
Hydrides
Costs
Oxidoreductases
Industry

Keywords

  • cofactor regeneration
  • NADH
  • NADPH
  • method
  • heterogeneous catalysis
  • photocatalytic
  • electrochemical
  • enzymatic
  • homogeneous catalysis
  • hydrogen
  • H2

Cite this

Wang, X., Saba, T., Yiu, H. H. P., Howe, R. F., Anderson, J. A., & Shi, J. (2017). Cofactor NAD(P)H regeneration inspired by heterogeneous pathways. Chem, 2(5), 621-654. https://doi.org/10.1016/j.chempr.2017.04.009

Cofactor NAD(P)H regeneration inspired by heterogeneous pathways. / Wang, Xiaodong (Corresponding Author); Saba, Tony; Yiu, Humphrey H.P.; Howe, Russell F.; Anderson, James A; Shi, Jiafu (Corresponding Author).

In: Chem, Vol. 2, No. 5, 11.05.2017, p. 621-654.

Research output: Contribution to journalArticle

Wang, X, Saba, T, Yiu, HHP, Howe, RF, Anderson, JA & Shi, J 2017, 'Cofactor NAD(P)H regeneration inspired by heterogeneous pathways', Chem, vol. 2, no. 5, pp. 621-654. https://doi.org/10.1016/j.chempr.2017.04.009
Wang, Xiaodong ; Saba, Tony ; Yiu, Humphrey H.P. ; Howe, Russell F. ; Anderson, James A ; Shi, Jiafu . / Cofactor NAD(P)H regeneration inspired by heterogeneous pathways. In: Chem. 2017 ; Vol. 2, No. 5. pp. 621-654.
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