Comparison of Blood Transfusion Plus Chelation Therapy and Bone Marrow Transplantation in Patients with β-Thalassemia: Application of SF-36, EQ-5D, and Visual Analogue Scale Measures

Mehdi Javanbakht, Ali Keshtkaran, Hossien Shabaninejad, Hassan Karami, Maryam Zakerinia, Sajad Delavari

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: β-Thalassemia is a prevalent genetic disease in Mediterranean countries. The most common treatments for this disease are blood transfusion plus iron chelation (BTIC) therapy and bone marrow transplantation (BMT). Patients using these procedures experience different health-related quality of life (HRQoL). The purpose of the present study was to measure HRQoL in these patients using 2 different multiattribute quality of life (QoL) scales.

METHODS: In this cross-sectional study, data were gathered using 3 instruments: a socio-demographic questionnaire, EQ-5D, and SF-36. A total of 196 patients with β-thalassemia were randomly selected from 2 hospitals in Shiraz (Southern Iran). Data were analyzed using logistic regression and multiple regression models to identify factors that affect the patients' HRQoL.

RESULTS: The average EQ-5D index and EQ visual analog scale (VAS) scores were 0.86 (95% CI: 0.83-0.89) and 71.85 (95% CI: 69.13-74.58), respectively. Patients with BMT reported significantly higher EQ VAS scores (83.27 vs 68.55, respectively). The results showed that patients who lived in rural area and patients with BMT reported higher EQ VAS scores (rural; β= 10.25, P = .006 and BMT; β= 11.88, P = .000). As well, SF-36 between 2 groups of patients were statistically significant in physical component scale (PCS).

CONCLUSION: Patients in the BMT group experienced higher HRQoL in both physical and mental aspects compared to those in the BTIC group. More studies are needed to assess the relative cost-effectiveness of these methods in developing countries.

Original languageEnglish
Pages (from-to)733-740
Number of pages8
JournalInternational journal of health policy and management
Volume4
Issue number11
Early online date13 Jun 2015
DOIs
Publication statusPublished - Nov 2015

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Chelation Therapy
Thalassemia
Bone Marrow Transplantation
Visual Analog Scale
Blood Transfusion
Quality of Life
Iron
Inborn Genetic Diseases
Iran
Developing Countries
Cost-Benefit Analysis
Cross-Sectional Studies
Logistic Models
Demography

Keywords

  • β-Thalassemia
  • Health Related Quality of Life (HRQoL)
  • blood transfusion
  • bone marrow transplantation

Cite this

Comparison of Blood Transfusion Plus Chelation Therapy and Bone Marrow Transplantation in Patients with β-Thalassemia : Application of SF-36, EQ-5D, and Visual Analogue Scale Measures. / Javanbakht, Mehdi; Keshtkaran, Ali; Shabaninejad, Hossien; Karami, Hassan; Zakerinia, Maryam; Delavari, Sajad.

In: International journal of health policy and management, Vol. 4, No. 11, 11.2015, p. 733-740.

Research output: Contribution to journalArticle

Javanbakht, Mehdi ; Keshtkaran, Ali ; Shabaninejad, Hossien ; Karami, Hassan ; Zakerinia, Maryam ; Delavari, Sajad. / Comparison of Blood Transfusion Plus Chelation Therapy and Bone Marrow Transplantation in Patients with β-Thalassemia : Application of SF-36, EQ-5D, and Visual Analogue Scale Measures. In: International journal of health policy and management. 2015 ; Vol. 4, No. 11. pp. 733-740.
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abstract = "BACKGROUND: β-Thalassemia is a prevalent genetic disease in Mediterranean countries. The most common treatments for this disease are blood transfusion plus iron chelation (BTIC) therapy and bone marrow transplantation (BMT). Patients using these procedures experience different health-related quality of life (HRQoL). The purpose of the present study was to measure HRQoL in these patients using 2 different multiattribute quality of life (QoL) scales.METHODS: In this cross-sectional study, data were gathered using 3 instruments: a socio-demographic questionnaire, EQ-5D, and SF-36. A total of 196 patients with β-thalassemia were randomly selected from 2 hospitals in Shiraz (Southern Iran). Data were analyzed using logistic regression and multiple regression models to identify factors that affect the patients' HRQoL.RESULTS: The average EQ-5D index and EQ visual analog scale (VAS) scores were 0.86 (95{\%} CI: 0.83-0.89) and 71.85 (95{\%} CI: 69.13-74.58), respectively. Patients with BMT reported significantly higher EQ VAS scores (83.27 vs 68.55, respectively). The results showed that patients who lived in rural area and patients with BMT reported higher EQ VAS scores (rural; β= 10.25, P = .006 and BMT; β= 11.88, P = .000). As well, SF-36 between 2 groups of patients were statistically significant in physical component scale (PCS).CONCLUSION: Patients in the BMT group experienced higher HRQoL in both physical and mental aspects compared to those in the BTIC group. More studies are needed to assess the relative cost-effectiveness of these methods in developing countries.",
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note = "Date of Acceptance: 08/06/2015 {\circledC} 2015 by Kerman University of Medical Sciences. Acknowledgments The present article was extracted from the thesis written by Hassan Karami and was financially supported by Shiraz University of Medical Sciences, Shiraz, Iran (grant No. 6292). The authors would like to thank all participants in the study IJHPM supports the Open Access initiative. Abstracts and full texts (PDF format) of all articles published by IJHPM are freely accessible to everyone immediately upon publication. IJHPM also does not charge any submission or publication fees.",
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T1 - Comparison of Blood Transfusion Plus Chelation Therapy and Bone Marrow Transplantation in Patients with β-Thalassemia

T2 - Application of SF-36, EQ-5D, and Visual Analogue Scale Measures

AU - Javanbakht, Mehdi

AU - Keshtkaran, Ali

AU - Shabaninejad, Hossien

AU - Karami, Hassan

AU - Zakerinia, Maryam

AU - Delavari, Sajad

N1 - Date of Acceptance: 08/06/2015 © 2015 by Kerman University of Medical Sciences. Acknowledgments The present article was extracted from the thesis written by Hassan Karami and was financially supported by Shiraz University of Medical Sciences, Shiraz, Iran (grant No. 6292). The authors would like to thank all participants in the study IJHPM supports the Open Access initiative. Abstracts and full texts (PDF format) of all articles published by IJHPM are freely accessible to everyone immediately upon publication. IJHPM also does not charge any submission or publication fees.

PY - 2015/11

Y1 - 2015/11

N2 - BACKGROUND: β-Thalassemia is a prevalent genetic disease in Mediterranean countries. The most common treatments for this disease are blood transfusion plus iron chelation (BTIC) therapy and bone marrow transplantation (BMT). Patients using these procedures experience different health-related quality of life (HRQoL). The purpose of the present study was to measure HRQoL in these patients using 2 different multiattribute quality of life (QoL) scales.METHODS: In this cross-sectional study, data were gathered using 3 instruments: a socio-demographic questionnaire, EQ-5D, and SF-36. A total of 196 patients with β-thalassemia were randomly selected from 2 hospitals in Shiraz (Southern Iran). Data were analyzed using logistic regression and multiple regression models to identify factors that affect the patients' HRQoL.RESULTS: The average EQ-5D index and EQ visual analog scale (VAS) scores were 0.86 (95% CI: 0.83-0.89) and 71.85 (95% CI: 69.13-74.58), respectively. Patients with BMT reported significantly higher EQ VAS scores (83.27 vs 68.55, respectively). The results showed that patients who lived in rural area and patients with BMT reported higher EQ VAS scores (rural; β= 10.25, P = .006 and BMT; β= 11.88, P = .000). As well, SF-36 between 2 groups of patients were statistically significant in physical component scale (PCS).CONCLUSION: Patients in the BMT group experienced higher HRQoL in both physical and mental aspects compared to those in the BTIC group. More studies are needed to assess the relative cost-effectiveness of these methods in developing countries.

AB - BACKGROUND: β-Thalassemia is a prevalent genetic disease in Mediterranean countries. The most common treatments for this disease are blood transfusion plus iron chelation (BTIC) therapy and bone marrow transplantation (BMT). Patients using these procedures experience different health-related quality of life (HRQoL). The purpose of the present study was to measure HRQoL in these patients using 2 different multiattribute quality of life (QoL) scales.METHODS: In this cross-sectional study, data were gathered using 3 instruments: a socio-demographic questionnaire, EQ-5D, and SF-36. A total of 196 patients with β-thalassemia were randomly selected from 2 hospitals in Shiraz (Southern Iran). Data were analyzed using logistic regression and multiple regression models to identify factors that affect the patients' HRQoL.RESULTS: The average EQ-5D index and EQ visual analog scale (VAS) scores were 0.86 (95% CI: 0.83-0.89) and 71.85 (95% CI: 69.13-74.58), respectively. Patients with BMT reported significantly higher EQ VAS scores (83.27 vs 68.55, respectively). The results showed that patients who lived in rural area and patients with BMT reported higher EQ VAS scores (rural; β= 10.25, P = .006 and BMT; β= 11.88, P = .000). As well, SF-36 between 2 groups of patients were statistically significant in physical component scale (PCS).CONCLUSION: Patients in the BMT group experienced higher HRQoL in both physical and mental aspects compared to those in the BTIC group. More studies are needed to assess the relative cost-effectiveness of these methods in developing countries.

KW - β-Thalassemia

KW - Health Related Quality of Life (HRQoL)

KW - blood transfusion

KW - bone marrow transplantation

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