Cooperative response and clustering: Consequences of membrane-mediated interactions among mechanosensitive channels

Lucas D. Fernandes, Ksenia Guseva, Alessandro P.S. De Moura

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Abstract

Mechanosensitive channels are ion channels which act as cells' safety valves, opening when the osmotic pressure becomes too high and making cells avoid damage by releasing ions. They are found on the cellular membrane of a large number of organisms. They interact with each other by means of deformations they induce in the membrane. We show that collective dynamics arising from the interchannel interactions lead to first- and second-order phase transitions in the fraction of open channels in equilibrium relating to the formation of channel clusters. We show that this results in a considerable delay of the response of cells to osmotic shocks, and to an extreme cell-to-cell stochastic variations in their response times, despite the large numbers of channels present in each cell. We discuss how our results are relevant for E. coli.

Original languageEnglish
Article number022410
JournalPhysical Review E
Volume96
Issue number2
DOIs
Publication statusPublished - 21 Aug 2017

Fingerprint

Membrane
Clustering
membranes
Cell
cells
Interaction
interactions
Open Channel
Ion Channels
osmosis
releasing
organisms
Escherichia Coli
Response Time
Shock
safety
Extremes
Phase Transition
Damage
Safety

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

Cite this

Cooperative response and clustering : Consequences of membrane-mediated interactions among mechanosensitive channels. / Fernandes, Lucas D.; Guseva, Ksenia; De Moura, Alessandro P.S.

In: Physical Review E, Vol. 96, No. 2, 022410, 21.08.2017.

Research output: Contribution to journalArticle

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