Correlation between Choline Peak at MR Spectroscopy and Calcium-Sensing Receptor Expression Level in Breast Cancer: A Preliminary Clinical Study

Gabriella Baio; Giuseppe Rescinito; Francesca Rosa; Daniele Pace; Simona Boccardo; Luca Basso; Sandra Salvi; Massimo Calabrese; Mauro Truini; Carlo Emanuele Neumaier

doi:10.1007/s11307-015-0823-y

Correlation between Choline Peak at MR Spectroscopy and Calcium-Sensing Receptor Expression Level in Breast Cancer: A Preliminary Clinical Study

Gabriella Baio, Giuseppe Rescinito, Francesca Rosa, Daniele Pace, Simona Boccardo, Luca Basso, Sandra Salvi, Massimo Calabrese, Mauro Truini, Carlo Emanuele Neumaier

Applied Medicine

University of Genoa

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

PURPOSE: The calcium-sensing receptor (CaSR) is overexpressed in many pathological states including breast cancer. Since choline kinase may be activated in breast cancer cells by CaSR resulting in increased phosphocholine production, we sought to correlate the total choline peak in breast lesions as measured by in vivo proton magnetic resonance spectroscopy ((1)H-MRS) with the CaSR expression levels in surgical specimens.

PROCEDURES: Thirty-six patients with breast lesions were MR scanned at 3T scanner. Tumour morphology and DCE-MR kinetics were evaluated. (1)H-MRS was applied for Cho detection and compared with the CaSR immunohistochemistry analysis (score 0-5) on surgical breast specimens.

RESULTS: Thirty-four lesions demonstrated a DCE malignant kinetics curve (types 2 and 3), while two lesions showed a benign (type 1). Twenty of the 23 breast cancer lesions (87 %) with a consistent Cho peak expressed a CaSR score of 3-5, and ten of the 11 breast lesions negative for Cho (91 %) had a CaSR score of 1-2. The two benign lesions showed a non-uniform/weak intense expression of the CaSR (score 3) with a consistent Cho peak.

CONCLUSIONS: The presence or absence of choline peak evaluated by (1)H-MRS, well correlated with the expression of CaSR in patients with breast lesions (p < 0.01), supports the hypothesis that CaSR may play an important role in the production of choline in breast cancer.

Original language	English
Pages (from-to)	548-556
Number of pages	9
Journal	Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
Volume	17
Issue number	4
Early online date	23 Jan 2015
DOIs	https://doi.org/10.1007/s11307-015-0823-y
Publication status	Published - Aug 2015

Bibliographical note

Acknowledgments.
The authors thank Mrs Teresa Morris, Coordinator of
Aberdeen Biomedical Imaging, University of Aberdeen, UK, for his helpful
revision of the manuscript, in particular for English editing

Keywords

calcium-sensing receptor
MR spectroscopy
breast cancer
phosphocholine
3T MR
magnetic resonance imaging
G protein-coupled receptor
Calcium channels
MRI breast
Molecular imaging cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Baio, G., Rescinito, G., Rosa, F., Pace, D., Boccardo, S., Basso, L., Salvi, S., Calabrese, M., Truini, M., & Neumaier, C. E. (2015). Correlation between Choline Peak at MR Spectroscopy and Calcium-Sensing Receptor Expression Level in Breast Cancer: A Preliminary Clinical Study. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 17(4), 548-556. https://doi.org/10.1007/s11307-015-0823-y

Correlation between Choline Peak at MR Spectroscopy and Calcium-Sensing Receptor Expression Level in Breast Cancer: A Preliminary Clinical Study. / Baio, Gabriella; Rescinito, Giuseppe; Rosa, Francesca et al.
In: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, Vol. 17, No. 4, 08.2015, p. 548-556.

Research output: Contribution to journal › Article › peer-review

Baio, G, Rescinito, G, Rosa, F, Pace, D, Boccardo, S, Basso, L, Salvi, S, Calabrese, M, Truini, M & Neumaier, CE 2015, 'Correlation between Choline Peak at MR Spectroscopy and Calcium-Sensing Receptor Expression Level in Breast Cancer: A Preliminary Clinical Study', Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, vol. 17, no. 4, pp. 548-556. https://doi.org/10.1007/s11307-015-0823-y

Baio G, Rescinito G, Rosa F, Pace D, Boccardo S, Basso L et al. Correlation between Choline Peak at MR Spectroscopy and Calcium-Sensing Receptor Expression Level in Breast Cancer: A Preliminary Clinical Study. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2015 Aug;17(4):548-556. Epub 2015 Jan 23. doi: 10.1007/s11307-015-0823-y

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title = "Correlation between Choline Peak at MR Spectroscopy and Calcium-Sensing Receptor Expression Level in Breast Cancer: A Preliminary Clinical Study",

abstract = "PURPOSE: The calcium-sensing receptor (CaSR) is overexpressed in many pathological states including breast cancer. Since choline kinase may be activated in breast cancer cells by CaSR resulting in increased phosphocholine production, we sought to correlate the total choline peak in breast lesions as measured by in vivo proton magnetic resonance spectroscopy ((1)H-MRS) with the CaSR expression levels in surgical specimens.PROCEDURES: Thirty-six patients with breast lesions were MR scanned at 3T scanner. Tumour morphology and DCE-MR kinetics were evaluated. (1)H-MRS was applied for Cho detection and compared with the CaSR immunohistochemistry analysis (score 0-5) on surgical breast specimens.RESULTS: Thirty-four lesions demonstrated a DCE malignant kinetics curve (types 2 and 3), while two lesions showed a benign (type 1). Twenty of the 23 breast cancer lesions (87 %) with a consistent Cho peak expressed a CaSR score of 3-5, and ten of the 11 breast lesions negative for Cho (91 %) had a CaSR score of 1-2. The two benign lesions showed a non-uniform/weak intense expression of the CaSR (score 3) with a consistent Cho peak.CONCLUSIONS: The presence or absence of choline peak evaluated by (1)H-MRS, well correlated with the expression of CaSR in patients with breast lesions (p < 0.01), supports the hypothesis that CaSR may play an important role in the production of choline in breast cancer.",

keywords = "calcium-sensing receptor, MR spectroscopy, breast cancer, phosphocholine, 3T MR, magnetic resonance imaging, G protein-coupled receptor, Calcium channels , MRI breast, Molecular imaging cancer",

author = "Gabriella Baio and Giuseppe Rescinito and Francesca Rosa and Daniele Pace and Simona Boccardo and Luca Basso and Sandra Salvi and Massimo Calabrese and Mauro Truini and Neumaier, {Carlo Emanuele}",

note = "Acknowledgments. The authors thank Mrs Teresa Morris, Coordinator of Aberdeen Biomedical Imaging, University of Aberdeen, UK, for his helpful revision of the manuscript, in particular for English editing",

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doi = "10.1007/s11307-015-0823-y",

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T1 - Correlation between Choline Peak at MR Spectroscopy and Calcium-Sensing Receptor Expression Level in Breast Cancer

T2 - A Preliminary Clinical Study

AU - Baio, Gabriella

AU - Rescinito, Giuseppe

AU - Rosa, Francesca

AU - Pace, Daniele

AU - Boccardo, Simona

AU - Basso, Luca

AU - Salvi, Sandra

AU - Calabrese, Massimo

AU - Truini, Mauro

AU - Neumaier, Carlo Emanuele

N1 - Acknowledgments. The authors thank Mrs Teresa Morris, Coordinator of Aberdeen Biomedical Imaging, University of Aberdeen, UK, for his helpful revision of the manuscript, in particular for English editing

PY - 2015/8

Y1 - 2015/8

N2 - PURPOSE: The calcium-sensing receptor (CaSR) is overexpressed in many pathological states including breast cancer. Since choline kinase may be activated in breast cancer cells by CaSR resulting in increased phosphocholine production, we sought to correlate the total choline peak in breast lesions as measured by in vivo proton magnetic resonance spectroscopy ((1)H-MRS) with the CaSR expression levels in surgical specimens.PROCEDURES: Thirty-six patients with breast lesions were MR scanned at 3T scanner. Tumour morphology and DCE-MR kinetics were evaluated. (1)H-MRS was applied for Cho detection and compared with the CaSR immunohistochemistry analysis (score 0-5) on surgical breast specimens.RESULTS: Thirty-four lesions demonstrated a DCE malignant kinetics curve (types 2 and 3), while two lesions showed a benign (type 1). Twenty of the 23 breast cancer lesions (87 %) with a consistent Cho peak expressed a CaSR score of 3-5, and ten of the 11 breast lesions negative for Cho (91 %) had a CaSR score of 1-2. The two benign lesions showed a non-uniform/weak intense expression of the CaSR (score 3) with a consistent Cho peak.CONCLUSIONS: The presence or absence of choline peak evaluated by (1)H-MRS, well correlated with the expression of CaSR in patients with breast lesions (p < 0.01), supports the hypothesis that CaSR may play an important role in the production of choline in breast cancer.

AB - PURPOSE: The calcium-sensing receptor (CaSR) is overexpressed in many pathological states including breast cancer. Since choline kinase may be activated in breast cancer cells by CaSR resulting in increased phosphocholine production, we sought to correlate the total choline peak in breast lesions as measured by in vivo proton magnetic resonance spectroscopy ((1)H-MRS) with the CaSR expression levels in surgical specimens.PROCEDURES: Thirty-six patients with breast lesions were MR scanned at 3T scanner. Tumour morphology and DCE-MR kinetics were evaluated. (1)H-MRS was applied for Cho detection and compared with the CaSR immunohistochemistry analysis (score 0-5) on surgical breast specimens.RESULTS: Thirty-four lesions demonstrated a DCE malignant kinetics curve (types 2 and 3), while two lesions showed a benign (type 1). Twenty of the 23 breast cancer lesions (87 %) with a consistent Cho peak expressed a CaSR score of 3-5, and ten of the 11 breast lesions negative for Cho (91 %) had a CaSR score of 1-2. The two benign lesions showed a non-uniform/weak intense expression of the CaSR (score 3) with a consistent Cho peak.CONCLUSIONS: The presence or absence of choline peak evaluated by (1)H-MRS, well correlated with the expression of CaSR in patients with breast lesions (p < 0.01), supports the hypothesis that CaSR may play an important role in the production of choline in breast cancer.

KW - calcium-sensing receptor

KW - MR spectroscopy

KW - breast cancer

KW - phosphocholine

KW - 3T MR

KW - magnetic resonance imaging

KW - G protein-coupled receptor

KW - Calcium channels

KW - MRI breast

KW - Molecular imaging cancer

U2 - 10.1007/s11307-015-0823-y

DO - 10.1007/s11307-015-0823-y

M3 - Article

C2 - 25613673

SN - 1860-2002

VL - 17

SP - 548

EP - 556

JO - Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging

JF - Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging

IS - 4

ER -

Correlation between Choline Peak at MR Spectroscopy and Calcium-Sensing Receptor Expression Level in Breast Cancer: A Preliminary Clinical Study

Abstract

Bibliographical note

Keywords

UN SDGs

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