Curcumin in tissue engineering: A traditional remedy for modern medicine

Najmeh Ahangari, Saeid Kargozar, Majid Ghayour-Mobarhan, Francesco Baino, Alireza Pasdar, Amirhossein Sahebkar, Gordon A.A. Ferns, Hae Won Kim, Masoud Mozafari*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

Curcumin is the principal polyphenolic compound present in turmeric with broad applications in tissue engineering and regenerative medicine. It has some important inherent properties with the potential to facilitate tissue healing, including anti-inflammatory, anti-oxidant, and antibacterial activities. Therefore, curcumin has been used for the treatment of various damaged tissues, especially wound injuries. There are different forms of curcumin, among which nano-formulations are of a great importance in regenerative medicine. It is also important to design sophisticated delivery systems for controlled/localized delivery of curcumin to the target tissues and organs. Although there are many reports on the advantages of this compound, further research is required to fully explore its clinical usage. The review describes the physicochemical and biological properties of curcumin and the current state of the evidence on its applications in tissue engineering.

Original languageEnglish
Pages (from-to)135-151
Number of pages17
JournalBioFactors
Volume45
Issue number2
Early online date8 Dec 2018
DOIs
Publication statusPublished - 1 Mar 2019

Keywords

  • anti-inflammation
  • anti-oxidant
  • antibacterial
  • curcumin
  • scaffold
  • tissue engineering
  • tissue repair
  • wound healing

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