Macrocyclic peptides have promising therapeutic potential but the scaling up of their chemical synthesis is challenging. The cyanobactin macrocyclase PatGmac is an efficient tool for production but is limited to substrates containing 6–11 amino acids and at least one thiazoline or proline. Here we report a new cyanobactin macrocyclase that can cyclize longer peptide substrates and those not containing proline/thiazoline and thus allows exploring a wider chemical diversity.
|Number of pages||4|
|Early online date||11 Sep 2017|
|Publication status||Published - 4 Oct 2017|
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Wael E Houssen
- School of Medicine, Medical Sciences & Nutrition, Medical Sciences - Reader
- Institute of Medical Sciences